HOME >> MEDICINE >> NEWS
Study may lead to new means of increasing effectiveness of existing cancer treatments

Researchers at Mount Sinai School of Medicine have discovered a new mechanism of activation of a pathway known to be implicated in many cancers. Additionally, the researchers found that when this mechanism is blocked cells may become more sensitive to radiation and chemotherapeutic agents, thus making them easier to destroy. The research was published in the November issue of Cancer Cell.

The researchers investigated the Wnt pathway, which is known to be integral to regulation of cell differentiation the process by which a stem cell develops into a specific type of cell. Once differentiated, cell proliferation is limited. When activated the Wnt pathway tells cells not to differentiate allowing them to grow unchecked, which can lead to development of a cancer.

Drs. Anna Bafico, Stuart Aaronson and colleagues at Mount Sinai School of Medicine discovered that in some breast, ovarian and colon cancer cells this pathway becomes active through triggering of a receptor on the surface of the cell. So, the cell can stimulate itself, remain in an undifferentiated state and continue to proliferate. Furthermore, they discovered that the pathway can be shut off at the cell surface by compounds that block the receptor. Once turned off, such cancer cells become more sensitive to agents that induce cell death.

While it was previously known that the Wnt pathway is involved in almost all cases of colon cancer and in some ovarian, and skin cancers, this study was the first to implicate this pathway in breast cancer and to identify this mechanism in human tumor cells.

"An increasing number of cancer therapeutic agents are being developed to block pathways activated by interactions at the cell surface," said Dr. Aaronson, Professor and Chairman of Oncological Sciences at Mount Sinai School of Medicine. "This research provides a novel target to interfere with a pathway that is implicated in many cancer types."

"Selectively interfering in this pa
'"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
22-Nov-2004


Page: 1 2

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2018)... ... December 07, 2018 , ... ... Service for its annual tradition of supporting non-profit organizations through fun, creative and ... employees helping raise more than $400,000 for charities in northeast Ohio and across ...
(Date:12/6/2018)... , ... December 06, 2018 , ... ... the tropical disease schistosomiasis significantly faster than the drug most commonly used against ... the Democratic Republic of Congo. The study’s authors, including a professor and two ...
(Date:12/5/2018)... ... December 05, 2018 , ... Bellus Medical, a ... a new standard as the premier FDA-cleared microneedling device. This award comes on ... is presented at the renowned Aesthetics Awards to products launched in the U.K. ...
(Date:12/5/2018)... ... 05, 2018 , ... Northeast Delta Human Services Authority will ... Monroe Baptist Church, 210 Finks Hideaway Rd, Monroe, LA 71203. , The training ... educate and equip faith leaders to address substance abuse prevention, support and recovery ...
(Date:12/5/2018)... ... ... Dr. Jessica Allen of Northern Colorado Periodontics is pleased to offer the ... the Fort Collins area. Dr. Allen joins an elite class of periodontists providing ... to gum disease. , "Gum disease is a problem that many people have, and ...
Breaking Medicine News(10 mins):
(Date:12/5/2018)... ... 2018 , ... NDA Partners Chairman Carl Peck, MD ... Integration at the United States Pharmacopeial Convention (USP), has joined the firm as ... in domestic and international operations harmonization, compendial affairs, and the development and management ...
(Date:11/29/2018)... ... November 29, 2018 , ... Windsor Gardens Healthcare Center ... in North Hollywood, CA, announced today they were selected by the California Association of ... a new Volunteer Engagement Project. , The California Department of Public Health awarded ...
(Date:11/28/2018)... ... November 28, 2018 , ... CME Outfitters ... a new partnership with CME Master, a division of HealthMinds Consulting Pvt. Ltd. ... into South East Asia expected soon. This new collaboration will provide access to ...
Breaking Medicine Technology:
Cached News: