HOME >> MEDICINE >> NEWS
Study of cancer trials finds significant safety improvement

The chance that patients participating in early-stage cancer research studies will die from the experimental treatments has dropped dramatically over the past decade, according to a study from the Massachusetts General Hospital (MGH) Cancer Center and the Massachusetts Institute of Technology (MIT). In an analysis of more than 200 Phase 1 research trials from 1991 through 2002, the researchers found that treatment-related deaths decreased by 90 percent during the study period. The report appears in the November 3 Journal of the American Medical Association.

"We undertook this study because there has been so much concern in recent years about the safety of clinical trials. We wanted to see if the increased attention to patient safety had made a difference and if the addition of targeted therapies, which tend to be less toxic, had also helped," says Thomas Roberts Jr., MD, of the MGH Cancer Center, the paper's lead author. "Now we can tell patients with cancer that, compared with 10 years ago, they can expect a higher level of safety when they enroll in early-stage clinical trials."

Representing the first time potential new drugs are tested in humans, phase 1 trials have a goal of assuring drug safety and determining the best dosage. While most of these early-stage studies enroll healthy volunteers, cancer studies have several important differences. Phase 1 cancer studies are usually restricted to patients with cancer who have exhausted established therapeutic options. While identifying toxic effects is the primary goal of most Phase 1 studies, cancer trials also have a secondary goal of evaluating anti-tumor effects.

Since there had been no comprehensive analysis of Phase 1 trials since the mid-1980s, the researchers compiled a database of Phase 1 trial results reported at the annual meeting of the American Society for Clinical Oncology from 1991 through 2002. In order to insure that the studies were comparable, the investigato
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
2-Nov-2004


Page: 1 2 3

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study cancer trials finds significant safety improvement

(Date:8/29/2014)... stimulating neurite extension in the presence of ... nerve regeneration following nerve crush injury and ... stimulate nerve regeneration is limited because of ... and its considerable cost. With long-term allografts, ... reportedly cause life-threatening infections. Like FK506, rapamycin ...
(Date:8/29/2014)... Spain Saturday 30 August 2014: New ESC ... acute coronary syndromes (ACS). The announcement comes as ... started and the study on heart failure patients ... Co-operation and Development (OECD) begins an outcomes evaluation. ... ESC,s EURObservational Research Programme (EORP). , Professor Roberto ...
(Date:8/29/2014)... As a chiropractic physician and medical ... there’s a direct connection between the condition of the ... "Since conventional shoe inserts and orthotics weren’t satisfying my ... own," he said. , Customizable to a user’s needs, ... the foot in order to help prevent pain in ...
(Date:8/29/2014)... Glendale Botox experts at Glenoaks Laser ... the month of September. This special offer features 10 free ... Juvederm. Patients can take advantage of this special offer to ... experts will work with patients to determine if Botox or ... Botox? , Botox is a treatment made from the ...
(Date:8/29/2014)... The main strain of a common antibiotic-resistant infection ... originated in sub-Saharan Africa, a new study says. ... aureus (CA-MRSA) infections, which occur in healthy ... infections typically affect the skin and can be ... objects such as clothing or towels. The ...
Breaking Medicine News(10 mins):Health News:New ESC registries launched on cardiac oncology and ACS 2Health News:New ESC registries launched on cardiac oncology and ACS 3Health News:New ESC registries launched on cardiac oncology and ACS 4Health News:Glenoaks Laser Center is Now Offering a Special Promotion on Botox for the Month of September 2Health News: European MRSA Originated in Sub-Saharan Africa, Study Finds 2
(Date:8/29/2014)... , Aug. 29, 2014 ... PHG AEX: PHIA) ... European Society of Cardiology (ESC) Congress ... highlighting the full range of its cardiology solutions serving clinicians ... from prevention and diagnosis, to ...
(Date:8/28/2014)... Aug. 28, 2014 Reportlinker.com ... report is available in its catalogue: ... Compliance Services Industry (U.S.): Analytics, Extensive ... to 2021, NAIC 541380 ... Testing Laboratories, Safety and Compliance ...
(Date:8/28/2014)... YORK , Aug. 28, 2014 ... is available in its catalogue: North ... http://www.reportlinker.com/p02343464/North-America-Laparoscopes-Market-Outlook-to-2020.html North America ... GlobalData,s new report, "North America Laparoscopes Market Outlook ... North America Laparoscopes market. The report provides value, ...
Breaking Medicine Technology:Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 3Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 4Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 2Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 4Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 6North America Laparoscopes Market Outlook to 2020 2North America Laparoscopes Market Outlook to 2020 3North America Laparoscopes Market Outlook to 2020 4North America Laparoscopes Market Outlook to 2020 5North America Laparoscopes Market Outlook to 2020 6North America Laparoscopes Market Outlook to 2020 7North America Laparoscopes Market Outlook to 2020 8North America Laparoscopes Market Outlook to 2020 9North America Laparoscopes Market Outlook to 2020 10North America Laparoscopes Market Outlook to 2020 11
Cached News: