Study questions benefits of costly schizophrenia drug

WEST HAVEN, Conn. - A study at 17 Veterans Affairs (VA) hospitals comparing an older, pennies-a-day schizophrenia drug with a newer, far more expensive one found little advantage to the high-ticket drug. The researchers, who report their findings in the November 26 issue of the Journal of the American Medical Association, say this is the first long-term, rigorously designed experimental study of the newer drug, which boasts U.S. sales of $2 billion annually.

The researchers compared haloperidol, one of an older class of schizophrenia drugs called typical antipsychotics, to olanzapine, the most expensive among the newer atypical antipsychotics. Used alone, the older medications are more likely to cause troubling side effects such as tremors and twitches. But the study had doctors prescribe haloperidol as they would ideally in actual practice-accompanied from the outset by another drug, benztropine, to minimize side effects.

"We gave the benztropine prophylactically along with the haloperidol, as is needed for a fair and clinically informative comparison," said lead author Robert Rosenheck, MD, director of VA's Northeast Program Evaluation Center in West Haven, Connecticut, and a professor of psychiatry and public health at Yale University Medical School.

"That's why we think this study is more relevant to everyday practice. We wanted to compare the two drugs in the way they are used in the real world."

The randomized, double-blinded study, which followed patients for one year, found no differences between the drugs in reducing schizophrenia symptoms or improving quality of life. As for side effects, olanzapine tended to cause weight gain. It resulted in slightly less akithesia, or restlessness, and somewhat better cognitive status, but not enough to improve patients' quality of life or overall functioning.

Though the drugs produced similar results overall, they come with a whopping difference in price: Olanzapine costs m

Contact: Pamela Redmond
VA Research Communications Service

Page: 1 2 3 4

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:

(Date:5/26/2020)... ... 26, 2020 , ... As much of the country continues ... are joining forces to start a country-wide movement of physical activity to honor ... #FitForTheFrontLine is a national fitness challenge beginning Tuesday, May 26 and culminating on ...
(Date:5/21/2020)... ... 21, 2020 , ... Summit Medical , an Innovia ... one million FDA-compliant face shields — designed, engineered and manufactured in the United ... for personal protective equipment (PPE) for both front-line health care workers and returning ...
(Date:5/21/2020)... ... May 21, 2020 , ... Friends of Lisa Campbell, announce that ... by Planned Parenthood Southeast Advocates (PPSEA). PPSEA educates and lobbies on ... the full range of reproductive health care. PPSEA educates and lobbies on behalf of ...
(Date:5/21/2020)... ... May 21, 2020 , ... Casenet® LLC today released ... supports care management and utilization management at health insurance plans. Developed over two ... provides significant usability and automation upgrades to all of its existing features, introduces ...
(Date:5/16/2020)... ... ... have gone to see Andy Gaertner, D.M.D , in the past, they will have ... allowed to re-open during the current pandemic, they have put some new protocols in place. ... possible while going through their dental exams and treatments. , The new protocols that Dr. ...
Breaking Medicine News(10 mins):
(Date:5/21/2020)... ... May 21, 2020 , ... ... Guests: Kevin Kearns, Boston, Massachusetts, founder/CEO of Burn with Kearns ( http://www.burnwithkearns.com ... largest association for fitness and wellness professional & competitive alpine skier Diana ...
(Date:5/17/2020)... ... May 17, 2020 , ... ... managed cybersecurity services by Insyte CPAs, LLC, an independent service auditor. This certification ... on which healthcare organizations can rely. , "It was a pleasure to work ...
(Date:5/16/2020)... ... May 15, 2020 , ... Sea Cucumbers have been used ... urination and joint pain, but have recently been making headlines for clinical findings ... immune system , naturally. , Sea Cucumbers are considered a delicacy in many ...
Breaking Medicine Technology:
Cached News: