Study raises prospect of practical vaccine for metastati...( x of immune system cells and substantia...)

Study raises prospect of practical vaccine for metastatic melanoma

x of immune system cells and substantial numbers of dead melanoma cells. Plus, ten of patients 29 percent of the original group were alive three years after receiving the treatment.

The results have encouraged Dranoff and his colleagues to undertake a larger, Phase II study of the vaccine and to test whether it can be effective in patients whose melanoma has not yet spread systematically.

"We plan to explore alternative techniques for producing the vaccine, as well as determining which patients can benefit from it the most," Dranoff remarks. "This will help us determine its proper place in the arsenal of melanoma treatments."

Co-authors of the study include Dana-Farber researchers Robert Soiffer, M.D., and Stephen Hodi, M.D.; Frank Haluska, MD, PhD, and Martin Mihm, MD, of Massachusetts General Hospital; and colleagues at Brigham and Women's Hospital, Harvard Medical School, Beth Israel Deaconess Medical Center, Children's Hospital Boston, and Cell Genesys of Foster City, Calif.

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Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
2-Sep-2003

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