SALT LAKE CITY, UTAH--Women with breast cancer who have a mastectomy often wish to proceed with reconstruction at the time of the mastectomy because of psychological, cosmetic and practical reasons. However, oncologists debate whether the reconstruction should be done before or after the radiation therapy. In a single-institution study conducted at Fox Chase Cancer Center, researchers have found low complication rates when breast cancer patients receive radiation therapy after reconstruction. Penny R. Anderson, M.D., a radiation oncologist at Fox Chase, presented the study results today at the 45th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Salt Lake City, Utah.
"Prior studies have shown a high rate of complications among breast cancer patients who undergo reconstruction and then post-mastectomy radiation therapy," said Anderson. "Anecdotally speaking, we weren't seeing major complications regularly at Fox Chase, and that observation became the impetus for this study."
The study involves 85 breast cancer patients who underwent a modified radical mastectomy, breast reconstruction and post-operative radiation therapy between 1987 and 2002. Reconstruction consisted of tissue expander placement with or without a subsequent permanent implant in 50 patients, and an autologous transverse rectus abdominis myocutaneous (TRAM) flap in 35 patients.
The median age of the women was 45 years. Seventy patients received radiation therapy after their mastectomy and reconstruction. The median time from reconstruction to radiation therapy was seven months. Fifteen patients received radiation therapy before their reconstruction.
The study defined major complications as those requiring corrective surgery or loss of reconstruction. Minor complications included infection, chest wall fibrosis, fat necrosis or contracture. Some of the clinical and treatment-related factors analyzed for a significant impact on coPage: 1 2 Related medicine news :1
Contact: Karen Carter Mallet
Fox Chase Cancer Center
. Study of energy and health in Africa focuses spotlight on charcoal and forest management2
. Study shows promise in identifying kidney failure3
. Study shows patch therapy may be as effective as oral medications4
. Study shows soy is well accepted in school lunches5
. Study finds that coordinating care of chronically ill patients does not increase liability6
. Study provides new estimates of the causes of child mortality worldwide7
. Study finds factors linked to substance use disorder relapse among health care professionals8
. Study finds majority of women willing to accept cervical cancer vaccine for self and children9
. Study shows use of budesonide reduced the risk of asthma related events by 40% in children10
. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased11
. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women