Honolulu, Hawaii (April 4, 2003) -- The leading Alzheimer's treatment, ARICEPT (donepezil HCl tablets), may also benefit patients with vascular dementia (VaD), according to a study analysis presented at the American Academy of Neurology (AAN) 55th Annual Meeting. There are no medications approved to treat VaD, which affects approximately 1.3 million Americans. VaD is caused by a single, localized stroke or series of strokes. A supplemental New Drug Application (sNDA) is under review by the U.S. Food and Drug Administration for the treatment of VaD with ARICEPT. ARICEPT is indicated for the treatment of mild to moderate AD.
This study analysis presented at AAN compared treated and untreated Alzheimer's disease (AD) and VaD patients. In these distinct populations, patients treated with ARICEPT demonstrated significant improvements in cognition, behavior, and activities of daily living, compared to those receiving placebo. There were important differences in the treatment response between AD and VaD patients. This study suggests that for VaD patients an important measure of treatment success is the improvement of symptoms. Treatment success for AD patients includes improvement, stabilization or a less-than-expected decline.
A collaboration dedicated to advances in Alzheimer's therapy.
"Currently, more than 60 percent of VaD patients are undiagnosed," said Dr. Stephen Salloway, director of Neurology and The Memory Disorders Program and associate professor of Clinical Neurosciences at Brown Medical School, Providence, Rhode Island. "This analysis supports the need for physicians to diagnose, as well as treat, their VaD patients. As the population ages and more people are at risk for VaD, treatment will become more critical than ever to address this growing health care issue."
Study Details Page: 1 2 3 Related medicine news :1
The research is a post-hoc analysis of 12 prospective studies, including two 24-week, double-blind, randomized, placebo-controlled
. Study of energy and health in Africa focuses spotlight on charcoal and forest management2
. Study shows promise in identifying kidney failure3
. Study shows patch therapy may be as effective as oral medications4
. Study shows soy is well accepted in school lunches5
. Study finds that coordinating care of chronically ill patients does not increase liability6
. Study provides new estimates of the causes of child mortality worldwide7
. Study finds factors linked to substance use disorder relapse among health care professionals8
. Study finds majority of women willing to accept cervical cancer vaccine for self and children9
. Study shows use of budesonide reduced the risk of asthma related events by 40% in children10
. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased11
. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women