Study shows Actonel reduces vertebral fracture risk 70 percent in patients on chronic stero...( ent release are also available at the U...),Health

ent release are also available at the U.S. Web site, or by calling 800-207-8049. Please see full prescribing information for Actonel for additional safety information. For a copy of the full prescribing information for Actonel please call 800-836-0658 or visit the Actonel Web site at http://www.actonel.com.

Statements in this news release other than historical information are forward-looking statements subject to risks and uncertainties. Actual results could differ materially depending on factors such as the availability of resources, the timing and effects of regulatory actions, the strength of competition, the outcome of litigation, and the effectiveness of patent protection. Additional information regarding risks and uncertainties is set forth in the current Annual Report on Form 20-F of Aventis on file with the Securities and Exchange Commission.

Glucocorticoid-induced osteoporosis

Overview

Glucocorticoid steroids are used to treat a wide variety of allergic and inflammatory diseases and are prescribed by a wide variety of physicians, both specialists and generalists.

Glucocorticoid-induced osteoporosis (GIO) is a serious complication associated with long-term oral glucocorticoid use (>7.5 mg prednisone or equivalent).

In as little as three months, chronic use of steroids (>7.5 mg/day of prednisone or equivalent) can cause significant bone loss, which could eventually lead to fracture.

Prevalence

Approximately 50 percent of patients on chronic glucocorticoid treatment (>7.5 mg prednisone or equivalent) will fracture.

The majority of patients on long-term glucocorticoid therapy for chronic disease do not receive treatment to prevent bone loss.

At-Risk Populations

Patients on long-term or chronic oral glucocorticoids such as prednisone, prednisolone, methylprednisolone, betamethasone, dexamethasone and triamcinolone (>7.5 mg pr
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Contact: Jim Guarnera
jguarner@hillandknowlton.com
212-885-0303
Hill and Knowlton
24-Oct-2001

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