HOME >> MEDICINE >> NEWS
Study shows drugs such as Vioxx and Celebrex were widely over-used long before recent problems

Even before making the connection between drugs such as Vioxx and heart attacks, many doctors were becoming concerned that the heavily advertised drugs known as COX-2 inhibitors were being over-used, often by patients unlikely to benefit from this costly but innovative pharmaceutical class.

In the January 25, 2005, issue of the Archives of Internal Medicine, researchers from the University of Chicago and Stanford University School of Medicine use data from the National Center for Health Statistics to show that most of the growth in COX-2 use between 1999 and 2002 occurred in patients at little risk for side effects from the drugs COX-2s were developed to replace.

"We found a rapid nationwide shift away from older, inexpensive drugs with better established safety and efficacy to newer, costly drugs with no real history," said study author G. Caleb Alexander, M.D., M.S., instructor of medicine and a member of the MacLean Center for Clinical Medical Ethics at the University of Chicago.

"We pursued our analysis because of concerns that this was an example of overuse of a newer, more expensive class of medications," said co-author Randall S. Stafford, M.D., Ph.D., associate professor and Director of the Program on Prevention Outcomes and Practice at Stanford University. "As with other examples in the treatment of high blood pressure, diabetes and some infections, there appears to be a tendency for new drugs to be used in a wider array of situations than supported by scientific studies."

The COX-2 inhibitors, introduced early in 1999, were widely promoted as "super aspirin." Ordinary aspirin blocks both COX-2, which triggers inflammation, as well as COX-1, which protects the stomach lining and helps to decrease the risk of GI bleeds and stomach ulcers. These newer and far more expensive drugs were designed to target only COX-2 and to be used to treat patients with chronic inflammatory disorders such as arthritis.

The C
'"/>

Contact: John Easton
John.Easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
21-Jan-2005


Page: 1 2 3

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2018)... RATON, Fla. (PRWEB) , ... December 06, 2018 ... ... those unable to cope with day-to-day life, there are alternative solutions. M.D.-formulated Relaxium ... , Relaxium Calm ’s main ingredient is Sensoril®, an extract of the ...
(Date:12/5/2018)... , ... December 05, 2018 , ... ... Wellness and Recovery , has been reappointed to serve on Philadelphia Mayor James ... that support inclusion of those who identify with a cognitive or physical disability. ...
(Date:12/5/2018)... ... December 05, 2018 , ... ... patient and family engagement with the use of the Precision Virtual Reality® ... provides Children’s National’s world-renowned neurosurgeons and physicians with a never-before view of ...
(Date:12/5/2018)... ... December 05, 2018 , ... Northeast Delta ... January 26 at North Monroe Baptist Church, 210 Finks Hideaway Rd, Monroe, LA ... the agency’s effort to educate and equip faith leaders to address substance abuse ...
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... ... and the causes of this condition are poorly understood. It manifests on the ... a life threatening condition, it can cause enormous social and psychological problems. , ...
Breaking Medicine News(10 mins):
(Date:12/6/2018)... WEST PALM BEACH, Fla. (PRWEB) , ... December 06, 2018 , ... ... partnering with “Speak Up for Kids Palm Beach”. The nonprofit serves 1500 children countywide ... stigma of addiction, but is also fighting against the stigma that surrounds local treatment ...
(Date:12/5/2018)... ... December 05, 2018 , ... HealthChannels, ... announced the hiring of Dr. Tony Andrulonis, MBA to lead company-wide operational performance ... over 20,000 medical scribes and support staff. Prior to joining HealthChannels, Andrulonis held ...
(Date:12/5/2018)... ... , ... Join the BFE in celebrating its 20th ... to nurture communication and education between specialists from different disciplines. Experts from neurofeedback, ... and learn. The meeting offers a broad range of basic and applied psychophysiology ...
Breaking Medicine Technology:
Cached News: