HOME >> MEDICINE >> NEWS
Study shows infliximab can maintain long-term remissions in Crohns disease

Periodic treatment with the monoclonal antibody infliximab can prolong remissions in patients with moderate to severe Crohn's disease, a multi-center research team reports today at the Digestive Disease Week meeting in Atlanta.

The ACCENT-I clinical trial is the first large-scale trial of infliximab (also known as REMICADE) used as maintenance therapy instead of as a treatment for acute attacks. The researchers found that after 30 weeks of therapy, patients receiving infusions of infliximab every eight weeks were twice as likely to be in remission as those who were not receiving the drug.

"This is the first therapy that truly allows us to manage this disease over time, rather than just treating flare ups," said lead investigator Stephen Hanauer, M.D., professor of medicine at the University of Chicago and director of the study. "Ongoing treatment with infliximab decreased disease activity, prevented sudden attacks, and enabled patients to reduce or, in many cases, completely eliminate steroids."

Infliximab was well tolerated throughout the 30 weeks of this trial without any unanticipated side effects.

Crohn's disease, a chronic inflammatory bowel disorder, affects approximately 500,000 Americans, typically beginning in late childhood or early adulthood. The disease causes inflammation of the gastrointestinal tract. It can result in diarrhea, fever, abdominal pain and weight loss. In up to 30 percent of patients, Crohn's disease causes fistulas -- openings that burrow through the bowel wall into nearby organs or through the surface of the skin.

The researchers enrolled 573 patients with moderate to severe Crohn's disease at 55 centers in North America, Europe, and Israel. All patients received an initial dose of infliximab. The 335 patie
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773-702-6241
University of Chicago Medical Center
20-May-2001


Page: 1 2 3

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2018)... ... August 17, 2018 , ... An August 7 article ... premature births and low birth weight could be significantly reduced if women were more ... gingivitis (gum disease) which a very large number of pregnant women suffer from to ...
(Date:8/15/2018)... ... August 15, 2018 , ... Today David Hyde Apparel debuts the first, fully ... out of a desire for confidence and comfort year-round, the new shirt leverages a ... in the hottest, most humid of climates. , The brainchild of two recent University ...
(Date:8/14/2018)... MIAMI (PRWEB) , ... August 14, 2018 , ... ... fastest-growing gastroenterology groups, today announced new leadership roles for healthcare executives Simon Frisch ... Division Vice President, Florida, respectively. They assume their roles at a time of ...
(Date:8/11/2018)... ... 10, 2018 , ... Dr. Siavash Eftekhari, Oral and Maxillofacial Surgeon at ... international outpost trip to deliver dental care in impoverished communities. Along with a team ... volunteered his time to help deliver care to over 550 individuals in need. , ...
(Date:8/9/2018)... ... August 09, 2018 , ... Thousands of US ... according to cross-referenced data from The American Society of Plastic Surgeons (ASPS), The ... monitored by the FDA. As an MRI is recommended by FDA after the ...
Breaking Medicine News(10 mins):
(Date:8/7/2018)... ... August 07, 2018 , ... ... of Richard A. Stark to assume the role of Sanarus Technologies President, effective immediately. Mr. ... of strategic development, marketing and sales experience in medical device toward finding new and ...
(Date:8/3/2018)... ... August 03, 2018 , ... In order to improve safety for everyone ... be mindful of the significant risks of injury that many amusement park rides present ... the Ferris wheel or a thrilling ride on a roller coaster. Unfortunately, these fun ...
(Date:8/2/2018)... ... August 02, 2018 , ... Periodontist, Dr. Andres ... crown lengthening treatment at his Eden Prairie, MN practice. Aesthetic crown ... self-conscious. Using decades of experience, Dr. Sanchez is excited to welcome new patients ...
Breaking Medicine Technology:
Cached News: