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Study shows long-term use of NSAIDs causes severe intestinal damage

Symptoms of dyspepsia (indigestion) associated with NSAID use are common in those who use these drugs long-term.

Study authors are hopeful that the use of video capsule endoscopy will allow future researchers to determine how often dyspepsia symptoms originate from small intestine injury and whether NSAID-associated small intestine damage causing anemia and leakage of blood proteins (hypoalbuminemia) can be attributed to specific findings visible by capsule endoscopy.

"Diseases of the small intestine contribute significantly to ill-health and often go undetected or misdiagnosed," said Graham. "We hope further studies will determine the clinical significance of our findings which show that extensive NSAID-related damage to the small intestine occurs more frequently than previously reported."

In 2003, the AGA launched the R.E.D.U.C.E. (Risk Education to Decrease Ulcer Complications and Their Effects from NSAIDs) Campaign to help explain the potentially harmful effects of NSAIDs and how Americans can lower their risk for serious gastrointestinal problems.


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Contact: Kimberly Wise
media@gastro.org
301-941-2620
American Gastroenterological Association
3-Jan-2005


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