HOME >> MEDICINE >> NEWS
Study shows positive results for novel, patient-controlled transdermal system (PCTS)...

iology, Pittsburgh School of Medicine. Annually, an estimated 20 million people in the U.S. require injectable opioids for the treatment of acute post-surgical pain.

A new-drug application was filed with the U.S. Food and Drug Administration in September 2003 by ALZA Corporation for the use of E-TRANS Fentanyl HCI PCTS for acute pain management requiring opioid analgesia in a medically supervised setting; a filing in the European Union is expected in 2004. ALZA Corporation developed the E-TRANS (electrotransport) system technology. If approved by the FDA, E-TRANS Fentanyl HCI PCTS will be marketed by Ortho-McNeil Pharmaceutical, Inc. in the United States and Janssen-Cilag in Europe. ALZA, Ortho-McNeil and Janssen-Cilag are subsidiaries of Johnson & Johnson.

This randomized, double-blind, placebo-controlled study included 154 patients treated with E-TRANS Fentanyl HCI PCTS and 51 patients treated with placebo. Of these, 142 patients randomized to E-TRANS Fentanyl HCI PCTS and 47 to placebo who stayed in the study 3 hours or longer were valuable for efficacy analyses. All patients were evaluated for safety and were made comfortable with supplemental intravenous opioids during the first three hours of the trial before using the system. More than half of all patients had undergone lower abdominal surgical procedure. Other patients in the study had undergone orthopedic or thoracic surgery. Patient demographics (age, height, weight and body mass index) were similar between the two groups at baseline.

The primary efficacy endpoint was the proportion of patients who dropped out due to inadequate analgesia. Additionally, the last level of pain recorded by patients in the study was lower in the E-TRANS Fentanyl HCI PCTS group than in the placebo group. A higher proportion of patients and investigators also reported greater pain control with E-TRANS Fentanyl HCI PCTS than with placebo based on global assessments of pain intensity.

The most co
'"/>


24-Feb-2004


Page: 1 2 3

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2020)... , ... April 04, 2020 , ... ... report conforming to the newly mandated federal reporting of COVID-19 testing that must ... March 29, 2020, Vice President Pence announced that all hospitals report data on ...
(Date:4/2/2020)... , ... April 02, 2020 , ... The Northern Virginia ... $1 million from donor Debra Coffman Howe of Palm Beach, Florida. Ms. Howe ... nursing students. Supporting NOVA nursing is more important than ever given the current ...
(Date:4/1/2020)... WASHINGTON (PRWEB) , ... April 01, 2020 , ... According ... women of reproductive age (13-44) in need of publicly funded contraception live in ... rule.” Nearly one-quarter of Minnesota’s counties have lost some or all of their Title ...
(Date:3/30/2020)... ... March 30, 2020 , ... Achieve Medical Center ... commitment to provide comprehensive and compassionate mental health and wellness services in the ... UpDox platform for telemedicine services including initial consultations, evaluations, and follow-up care. It ...
(Date:3/28/2020)... ... March 27, 2020 , ... To help ... now offering telemedicine as an alternative approach to seeing their patients. This approach ... the comfort of their own home or office using video conference and telecommunications ...
Breaking Medicine News(10 mins):
(Date:4/7/2020)... , ... April 07, 2020 , ... ... businesses serve their customers. Concerns over Coronavirus (COVID-19), has led to an increased ... stores, retailers, laboratories, pharmacies, medical centers and others. How businesses and customers physically ...
(Date:4/5/2020)... ... April 04, 2020 , ... Care Oncology, a UK-based company, ... company notes that new patient inquiries rose sharply by 35% since March 11 ... feel safer with our telemedicine delivery," says Jason Butcher, Director of Operations, US, ...
(Date:4/2/2020)... ... April 02, 2020 , ... In response ... Series, a portable, durable luminaire using Indigo-Clean Technology. These unique lighting fixtures provide ... and infection prevention protocols, and reducing harmful bacteria when used as recommended. , ...
Breaking Medicine Technology:
Cached News: