HOME >> MEDICINE >> NEWS
Study shows possible link between Parkinson's medication and cardiac valve disease

SAN FRANCISCO A recent study of Parkinson's disease patients who use the medication pergolide shows a possible link between pergolide and injured cardiac valves. Study details and conclusions will be presented at the American Academy of Neurology 56th Annual Meeting in San Francisco, Calif., April 24 May 1, 2004.

Valvular heart disease has been reported by various groups, totaling about 25 patients with Parkinson's disease who take pergolide. "These reports are anecdotal, from uncontrolled case studies," notes study author Richard B. Dewey, Jr., MD, associate professor of neurology, University of Texas Southwestern Medical Center in Dallas. "We were interested to know if this is a rare, idiosyncratic event or a common problem which has until now escaped notice."

Dewey and fellow researchers sent letters to more than 200 patients known to be taking pergolide for Parkinson's disease, and the responders who wished to continue pergolide were urged to undergo echocardiography. Echocardiograms were performed on 46 patients, and scores for valvular regurgitation (leakage) were compared to an age-matched control group from the Framingham Study (a well-documented heart disease study).

Two outcomes were compared: the presence of abnormal valvular leakage; and the presence of clinically significant leakage using criteria similar to that employed by the FDA in the fenfluramine/ phentermine ("Fen-Phen" diet aid) studies.

Eighty-nine percent (41) of pergolide-treated patients had some degree of valvular insufficiency. In two of three valves for which there is control data (the mitral and aortic), the study showed an approximately two- to three-fold increased risk (odds ratio 3) of regurgitation in the pergolide patients. In the tricuspid valve there was an estimated 14-fold increased risk of significant leakage (odds ratio 18).

"Our study demonstrates that pergolide may injure cardiac valves and, since they are available, consideration sh
'"/>

Contact: Kathy Stone
kstone@aan.com
651-695-2763
American Academy of Neurology
28-Apr-2004


Page: 1 2

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
(Date:8/28/2015)... ... August 28, 2015 , ... The Kentucky State Department of Workforce Investment Commissioner ... they are applying for, they are unable to pass the initial drug test and ... testing policies in order to be able to hire long-term, skilled talent. (1) Will ...
(Date:8/28/2015)... Dallas, TX (PRWEB) , ... August 28, 2015 , ... ... Surgical Center is taking part with their subsidiary USPI Tenet Health. , The American ... to fight heart disease and stroke. They believe that together, a difference can be ...
(Date:8/28/2015)... Hanover, MA (PRWEB) , ... August 28, 2015 , ... ... benefitting the renowned Brain Aneurysm Foundation has added yet another accolade to its ... Chicago, Rahm Emanuel. , “With the help of the medical community and ...
(Date:8/28/2015)... ... ... Saint Petersburg, FL —Pocket Protein™, a protein beverage that ... lactose or caffeine in a convenient 2 oz. pouch that never needs refrigeration, ... , Five consumer packaged goods (CPG) products were selected by the SupplySide editorial ...
(Date:8/28/2015)... ... August 28, 2015 , ... Drugs and ... James Strawbridge, gives a new approach on solutions in his new book ":Unraveling ... employer and employees getting together for meaningful group meetings. "This would educate the ...
Breaking Medicine News(10 mins):Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 2Health News:Pocket Protein™ Named 2015 CPG Editor’s Choice Award Finalist by Informa’s SupplySide 3
(Date:8/27/2015)... Aug. 27, 2015  The Academy of Managed ... Drug Administration,s (FDA,s) draft guidance and proposed rule ... biosimilars, to bear a nonproprietary name with an ... seeking a decision from the FDA on the ... care stakeholders urging the agency to use the ...
(Date:8/27/2015)... Aug. 27, 2015 DURECT Corporation (Nasdaq: ... present at three upcoming healthcare conferences.  ... will present at the Rodman & Renshaw Investment Conference ... The conference is being held at the St. Regis ... A live audio webcast of the presentation will be ...
(Date:8/27/2015)... ieCrowd™ today announced the achievement of ... the company,s supplemental oxygen delivery device, Smart Oxygen ... by ieCrowd,s subsidiary Smart Oxygen Solutions TM , ... oxygen based on level of activity.  The FDA ... Smart Oxygen device would require a series of ...
Breaking Medicine Technology:AMCP Is Disappointed in FDA's Draft Guidance and Proposed Rule Calling for Suffix on Nonproprietary Names of Biological Products 2DURECT to Participate in Upcoming Healthcare Conferences 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 2Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 3Smart Oxygen Solutions' Supplemental Oxygen Delivery Device Achieves FDA Regulatory Pathway Milestone 4
Cached News: