HOME >> MEDICINE >> NEWS
Study shows possible link between Parkinson's medication and cardiac valve disease

SAN FRANCISCO A recent study of Parkinson's disease patients who use the medication pergolide shows a possible link between pergolide and injured cardiac valves. Study details and conclusions will be presented at the American Academy of Neurology 56th Annual Meeting in San Francisco, Calif., April 24 May 1, 2004.

Valvular heart disease has been reported by various groups, totaling about 25 patients with Parkinson's disease who take pergolide. "These reports are anecdotal, from uncontrolled case studies," notes study author Richard B. Dewey, Jr., MD, associate professor of neurology, University of Texas Southwestern Medical Center in Dallas. "We were interested to know if this is a rare, idiosyncratic event or a common problem which has until now escaped notice."

Dewey and fellow researchers sent letters to more than 200 patients known to be taking pergolide for Parkinson's disease, and the responders who wished to continue pergolide were urged to undergo echocardiography. Echocardiograms were performed on 46 patients, and scores for valvular regurgitation (leakage) were compared to an age-matched control group from the Framingham Study (a well-documented heart disease study).

Two outcomes were compared: the presence of abnormal valvular leakage; and the presence of clinically significant leakage using criteria similar to that employed by the FDA in the fenfluramine/ phentermine ("Fen-Phen" diet aid) studies.

Eighty-nine percent (41) of pergolide-treated patients had some degree of valvular insufficiency. In two of three valves for which there is control data (the mitral and aortic), the study showed an approximately two- to three-fold increased risk (odds ratio 3) of regurgitation in the pergolide patients. In the tricuspid valve there was an estimated 14-fold increased risk of significant leakage (odds ratio 18).

"Our study demonstrates that pergolide may injure cardiac valves and, since they are available, consideration sh
'"/>

Contact: Kathy Stone
kstone@aan.com
651-695-2763
American Academy of Neurology
28-Apr-2004


Page: 1 2

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
(Date:11/22/2014)... Discount-Dress.com is an important company ... is to increase the company’s online market share by a ... of bridesmaid dresses and announced a bridesmaid dress promotion for ... Dec. 30, 2014. All the dresses from this company are ... In fact, Discount-Dress.com is very good at manufacturing wedding dresses. ...
(Date:11/22/2014)... November 22, 2014 Domestic farmgate ... slightly in 2009-10, due to a fall in ... industry products amid the global financial crisis. ... strength of Australian dairy manufacturers on the international ... products outweighed supply growth, primarily due to supply ...
(Date:11/22/2014)... November 22, 2014 Hastings and Hastings, ... of experience announces providing clients with the option of ... offers clients a flexible, intuitive and easy to navigate ... having access to Google + allows clients to research ... make a more informed decision when retaining an attorney. ...
(Date:11/22/2014)... November 22, 2014 A new ... announced today which safely detects and identifies hazards ... radio waves. Developed by RHT SpectraSafe, the technology ... broad applications in other areas including medical, recycling, ... , Using high frequency radio waves that pass ...
(Date:11/22/2014)... A clinical trial of hydroxyurea therapy for children with ... because the results show it is a safe and ... risk of stroke. The announcement about the research, ... United States and Canada, was made this week by ... Researchers compared monthly blood transfusions with daily hydroxyurea ...
Breaking Medicine News(10 mins):Health News:Bridesmaid Dresses Introduced by Famous Company Discount-Dress.com For The New Year 2015 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:Hastings and Hastings Announces Providing Clients with the Option of Leaving an Online Review Using Google + 2Health News:Hastings and Hastings Announces Providing Clients with the Option of Leaving an Online Review Using Google + 3Health News:RHT SpectraSafe announces a Radical New Airport Security Technology that Is More Effective, Less Invasive 2Health News:Sickle Cell Anemia Treatment So Successful in Kids That Trial Is Halted 2
(Date:11/22/2014)... Statistics released from a number of organizations ... during the holidays, beginning with Thanksgiving eve, which is ... The data, highlighted in an Infographic ... of their annual Sober Days for the Holidays ... drinking and increased rates of DUI injuries and deaths ...
(Date:11/22/2014)... HILL, N.C. , Nov. 21, 2014 /PRNewswire/ ... healthcare system. Undoubtedly, the growing influence of patients ... spend for marketing interactions. Now, more than ever, ... retain patients for medical products is essential. ... firm, Best Practices, LLC, benchmarked companies spent about ...
(Date:11/21/2014)... 2014  Tandem Diabetes Care ® , Inc. ... company and manufacturer of the t:slim ® ... a non-profit dedicated to improving diabetes therapy management ... increases diabetes data accessibility. This partnership will enable ... under development, to download and access data from ...
Breaking Medicine Technology:Alarming Stats Show Holiday Drinking an Issue for Many 2New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3
Cached News: