HOME >> MEDICINE >> NEWS
Study shows possible link between Parkinson's medication and cardiac valve disease

SAN FRANCISCO A recent study of Parkinson's disease patients who use the medication pergolide shows a possible link between pergolide and injured cardiac valves. Study details and conclusions will be presented at the American Academy of Neurology 56th Annual Meeting in San Francisco, Calif., April 24 May 1, 2004.

Valvular heart disease has been reported by various groups, totaling about 25 patients with Parkinson's disease who take pergolide. "These reports are anecdotal, from uncontrolled case studies," notes study author Richard B. Dewey, Jr., MD, associate professor of neurology, University of Texas Southwestern Medical Center in Dallas. "We were interested to know if this is a rare, idiosyncratic event or a common problem which has until now escaped notice."

Dewey and fellow researchers sent letters to more than 200 patients known to be taking pergolide for Parkinson's disease, and the responders who wished to continue pergolide were urged to undergo echocardiography. Echocardiograms were performed on 46 patients, and scores for valvular regurgitation (leakage) were compared to an age-matched control group from the Framingham Study (a well-documented heart disease study).

Two outcomes were compared: the presence of abnormal valvular leakage; and the presence of clinically significant leakage using criteria similar to that employed by the FDA in the fenfluramine/ phentermine ("Fen-Phen" diet aid) studies.

Eighty-nine percent (41) of pergolide-treated patients had some degree of valvular insufficiency. In two of three valves for which there is control data (the mitral and aortic), the study showed an approximately two- to three-fold increased risk (odds ratio 3) of regurgitation in the pergolide patients. In the tricuspid valve there was an estimated 14-fold increased risk of significant leakage (odds ratio 18).

"Our study demonstrates that pergolide may injure cardiac valves and, since they are available, consideration sh
'"/>

Contact: Kathy Stone
kstone@aan.com
651-695-2763
American Academy of Neurology
28-Apr-2004


Page: 1 2

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
(Date:4/20/2015)... (PRWEB) April 20, 2015 Early registration ... hurry and secure your space at the start line. ... the Olympic-distance race is limited to 500 participants (actually there’s ... already secured his spot). , Now thru April 30, the ... relay team members; after May 1st, the fee goes up ...
(Date:4/20/2015)... (PRWEB) April 20, 2015 Genuine fat loss ... diets and gym memberships in the past. But what failed ... results can be guaranteed by adhering to five simple ... diet. No matter how many hours one spends working at ... to lose weight., But a nutritional mean plan does not ...
(Date:4/20/2015)... 20, 2015 “ Verus ” was ... Report, which features the latest and coolest technology products ... special reporter for NewsWatch, conducted the review and shared ... variety of purposes. , According to CNET, at least ... in 2013. It’s unfortunate that smartphones break so easily, ...
(Date:4/20/2015)... Clara, CA (PRWEB) April 20, 2015 ... CA and were united as one until 1995. The group ... elements including blues, reggae, rock, bluegrass, folk, space rock, country, ... become known as the ultimate jam band. The group was ... 1994 and in total has sold more than 35 million ...
(Date:4/20/2015)... Tympani Inc., an IT consulting and ... services business 175% this year. Tympani offers a ... to its traditional IT infrastructure, communications and managed ... cloud partners Faction and Seagate Technology, will present ... a Cloud Symposium on April 23 in Rosemont, ...
Breaking Medicine News(10 mins):Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 2Health News:Hilo Triathlon Kicks Up Its Heels A Second Time; Early Bird Registration Available Online Now. 3Health News:Guarantee Fat Loss Results With 5 Easy Tips 2Health News:Guarantee Fat Loss Results With 5 Easy Tips 3Health News:Attractive and Durable Phone Cases were Featured on NewsWatch Television 2Health News:Grateful Dead Tickets at Levi’s Stadium in Santa Clara: Ticket Down Slashes Grateful Dead Tickets in Santa Clara @ Levi’s Stadium for "Fare Thee Well" 50th Anniversary 2Health News:Tympani Grows Cloud Services Business 175%, Presents Cloud Symposium on April 23 2Health News:Tympani Grows Cloud Services Business 175%, Presents Cloud Symposium on April 23 3
(Date:4/20/2015)... 2015   Spirox Inc., a privately held ... an $18.5 million Series B round of financing led by ... Partners, Correlation Ventures and Western Technology Investment also ... a novel, minimally invasive system to be used ... plastic surgeons to treat patients with nasal obstruction, ...
(Date:4/20/2015)... , Apr. 14, 2015 Research and Markets ... the "US Proton Therapy Outlook - Market Opportunities" ... the US Proton Therapy Outlook: Market Opportunities by the ... be home to almost 29 such centers by 2018, ... Consequently, the market will breach the Billion dollar mark ...
(Date:4/20/2015)... , April 20, 2015   Gateway Rehab ... and Training Institute today expanded its Naloxone: Increasing ... locations.  A $50,000 grant from the Staunton ... project possible.  The yearlong research ... patients and their family members upon completion of ...
Breaking Medicine Technology:Spirox, Inc. Announces Closing of $18.5MM Series B Financing 2Spirox, Inc. Announces Closing of $18.5MM Series B Financing 3United States Proton Therapy Outlook to 2018 - Market Opportunities for the $1.19 Billion Market Featuring IBA, Hitachi, Mevion Medical Systems & Varian 2United States Proton Therapy Outlook to 2018 - Market Opportunities for the $1.19 Billion Market Featuring IBA, Hitachi, Mevion Medical Systems & Varian 3Gateway Rehab and the Kenneth S. Ramsey, PhD Research and Training Institute expand Naloxone: Increasing Access, Saving Lives research project to outpatient locations 2Gateway Rehab and the Kenneth S. Ramsey, PhD Research and Training Institute expand Naloxone: Increasing Access, Saving Lives research project to outpatient locations 3
Cached News: