Study shows promise for HIV-infected liver transplant recipients

Contrary to current practice, HIV infection should no longer be considered an absolute contraindication to liver transplantation, according to an article published in the November 15 issue of The Journal of Infectious Diseases. Results of a recent multicenter study show that survival in HIV-positive transplant recipients was similar to that found in contemporaneous age- and race-matched HIV-negative recipients. These preliminary findings provide new hope for many HIV-infected patients who might otherwise die of end-stage liver disease.

With the advent of improved combined-drug treatment, particularly highly active antiretroviral therapies (HAART) in the mid-1990s, immune system function has been improved in HIV-infected patients and survival prolonged. But the incidence of liver failure in such patients has grown, especially among those coinfected with hepatitis C or hepatitis B viruses. Liver transplantation in patients with HIV infection invariably failed in the pre-HAART era because of opportunistic infection or graft rejection. The question was: Would HAART change the prospects for organ transplantation in HIV infection?

The study, reported by Margaret V. Ragni and coworkers at the University of Pittsburgh, the University of Miami, the University of California, San Francisco, King's College, London, and the University of Minnesota, involved 24 subjects with HIV infection and end-stage liver disease (due to hepatitis C in 15 and hepatitis B in 7) who were prospectively followed after orthotopic liver transplantation. All but two had had antiretroviral therapy preoperatively, and all but one were treated postoperatively.

The results: After a mean follow-up of 17 months, the cumulative 12-month survival was 87.1% in the HIV-infected transplant recipients, compared with 86.6% among 5,225 HIV-negative transplant recipients of comparable age, race, and date of transplantation, as recorded in a national liver transplant registry. The probabilit

Contact: Diana Olson
Infectious Diseases Society of America

Page: 1 2

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:

(Date:7/23/2019)... ... July 23, 2019 , ... Shady Grove Fertility ... the grand opening of its newest full-service fertility and in vitro fertilization (IVF) program ... new full-service location offers access to two leading, board certified reproductive endocrinologists, a state-of-the-art ...
(Date:7/21/2019)... , ... July 22, 2019 , ... Surgical facelifts might ... to an aging face, but not everyone wants or needs surgery, according to cosmetic ... Center, in Milford, Pa. , “For women and men who can’t tolerate the downtime ...
(Date:7/18/2019)... ... July 18, 2019 , ... The Radiology Business Management ... new bills to protect patients from unexpected out-of-network medical bills incurred while receiving ... Bills Act ( H.R. 3502 ), introduced in the U.S. House by Representatives ...
(Date:7/18/2019)... ATLANTA (PRWEB) , ... July 18, 2019 , ... ... surgeon Dr. Mark Deutsch is featured in Atlanta, Magazine’s list of “Top Doctors” ... years of cosmetic and reconstructive surgery, experience. With specialized training from MD Anderson ...
(Date:7/17/2019)... ... July 17, 2019 , ... The FDA has cleared the ... treating up to eight body areas simultaneously. Dr. Dennis Dass says the ... and easier than previous muscle toning devices or conventional exercise. , “The truSculpt® flex ...
Breaking Medicine News(10 mins):
(Date:7/17/2019)... ... July 17, 2019 , ... Halcyon, one of ... its payment processor of record. , As a result of the partnership, ... platform can now also accept and process payments through it, securely and easily. ...
(Date:7/17/2019)... LAWRENCEVILLE, Ga. (PRWEB) , ... July 17, 2019 , ... ... 30044, is an established and trusted provider of complete dental care, including general and ... The practice is staffed with a large team of extensively trained dentists, Dr. Kell ...
(Date:7/17/2019)... ... July 17, 2019 , ... ... DFree ®, the first wearable for urinary incontinence, will be highlighted at the ... CA, on July 26, 2019. The Innovation Showcase recognizes startups with Japanese founders ...
Breaking Medicine Technology:
Cached News: