HOME >> MEDICINE >> NEWS
Study suggests insulin may have potential to prevent thrombosis leading to heart attack and stroke

BUFFALO, N.Y. -- Insulin may interfere with the cascade of reactions that promote clot formation and platelet aggregation in heart-attack patients and may help prevent clot formation and plaque development in persons at risk of heart attack and stroke, new research by University at Buffalo endocrinologists has shown.

The researchers have demonstrated that an infusion of insulin and glucose suppresses a factor that regulates genes for two pro-inflammatory proteins that promote coagulation and clot formation in smooth muscle tissue lining blood vessels.

Results of the study appear in the March issue of the Journal of Clinical Endocrinology and Metabolism.

"Our earlier research showed for the first time that insulin exerts a significant anti-inflammatory effect on blood vessel walls, and now we have linked insulin with the mechanisms that reduce clotting factors," said Paresh Dandona, M.D., UB professor of medicine and senior author on the study.

"These new findings suggest that insulin has the potential to prevent thrombosis that leads to heart attack and stroke. It also may be useful to treat persons with those conditions through the prevention of clotting and promotion of dissolution of clots."

Dandona said the findings in this study add relevance to results from the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study, conducted in Stockholm, which showed that diabetic patients experiencing an acute heart attack who received a low dose infusion of insulin and glucose had a better outcome than patients who weren't infused. "The DIGAMI study showed that insulin has a positive effect on acute myocardial infarction, but the mechanisms weren't clear," he said. "Our studies are defining the mechanisms." The current investigation targeted a pro-inflammatory transcription factor, early growth response gene-1 (Egr-1), and concentrations in blood plasma of two proteins whose expression is regulated by Egr-1 -
'"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x 1417
University at Buffalo
21-Mar-2002


Page: 1 2

Related medicine news :

1. Study of energy and health in Africa focuses spotlight on charcoal and forest management
2. Study shows promise in identifying kidney failure
3. Study shows patch therapy may be as effective as oral medications
4. Study shows soy is well accepted in school lunches
5. Study finds that coordinating care of chronically ill patients does not increase liability
6. Study provides new estimates of the causes of child mortality worldwide
7. Study finds factors linked to substance use disorder relapse among health care professionals
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. Study shows use of budesonide reduced the risk of asthma related events by 40% in children
10. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
11. Study shows acrylamide in baked and fried food does not increase risk of breast cancer in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2019)... ... April 18, 2019 , ... It's time to try a ... Get to the root of the matter before those pesky dandruff flakes reach ... , Now you can attack dandruff before it attacks you. New Don’t ...
(Date:4/18/2019)... ... April 18, 2019 , ... Catalent, a global ... the upcoming Global Clinical Supplies Group (GCSG) 2019 US Annual Conference at the ... – May 1, 2019. , Erin Vlack, Project Manager, will present a workshop ...
(Date:4/18/2019)... ... April 18, 2019 , ... Dr. Matt Nejad is ... a full menu of cosmetic and general dental care services. Dr. Nejad is ... which relies on minimally-invasive techniques in restorative dentistry. Biomimetic dentistry uses a more ...
(Date:4/17/2019)... Fla. (PRWEB) , ... April 17, 2019 , ... With ... headlines, scientists are working to curb the death toll by looking for an alternative ... Spring 2019 National Meeting & Exposition this week. , Naloxone (often known by the ...
(Date:4/17/2019)... ... April 17, 2019 , ... ... reduce hangover symptoms. This California-made supplement was designed to lessen the negative ... now available for purchase via GotPurpleTree.com and Amazon.com . , ...
Breaking Medicine News(10 mins):
(Date:4/18/2019)... ... April 18, 2019 , ... ... of its industry-leading OPTIMASE® portfolio of biobased enzymes for medical instrument cleaning ... needs and specific challenges faced by medical instrument cleaning customers,” said Sheril ...
(Date:4/17/2019)... ATLANTA, Ga. (PRWEB) , ... April 17, 2019 ... ... solutions to healthcare providers and patients, announced today it has completed the acquisition ... Founded in 2012, Omni Holdings is the leading medical lien funding company operating ...
(Date:4/17/2019)... ... , ... Lillibridge Healthcare Services Inc., a wholly owned subsidiary ... of medical office buildings (MOBs), will sponsor and host three educational sessions featuring ... Association (BOMA) International Medical Office Buildings + Healthcare Facilities Conference May 1-3 in ...
Breaking Medicine Technology:
Cached News: