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Study supports triple combination therapy for HIV

Editorial: Initial antiretroviral regimens: in general three drugs are better than two are better than one BMJ Volume 324, pp 747-8

New evidence in this weeks BMJ supports the use of up to three antiviral drugs (triple therapy) to treat people with HIV.

Researchers in Birmingham reviewed 54 trials involving over 20,000 patients with HIV infection who had not already received antiviral therapy.

Combinations of up to three drugs were consistently and significantly more effective, but there was inadequate evidence on the effectiveness of quadruple or higher combinations. There was also marked variation, mainly accounted for by the drugs tested and issues of quality, say the authors.

Further work is needed to clarify which triple combination is the most effective and to investigate the effectiveness of quadruple or higher combinations, conclude the authors.


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Contact: Emma Wilkinson
ewilkinson@bmj.com
44-207-383-6529
BMJ-British Medical Journal
28-Mar-2002


Page: 1

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