HOME >> MEDICINE >> NEWS
Successful Cancer Therapy May Doom Later Treatments To Failure

molecules.

Shimmying through shrinking blood vessel pores is just one of many challenges facing drug agents. Ten years ago, Jain showed that just getting into the blood supply surrounding the tumors is a difficult task. "Nobody had measured resistance to blood flow in tumor vessels before. It was like walking into a wide open field," he says. Jain and his colleagues showed that the capillaries, arteries, and veins surrounding tumors are a jumbled mass -- thick in some areas and pinched at others -- rather than a neat and orderly array. And to make navigation even more difficult, the blood flowing through them is highly viscous -- more like sludge than water.

Blood vessels surrounding tumors are also known to be very leaky in some areas but not in others. It was only recently with the development of his immune-deficient mouse model that Jain was able to grow enough kinds of tumors to tackle the question of blood vessel pores systematically. He and his colleagues injected fluorescently labeled particles of increasing size in to the blood vessels of the six tumors at various locations and watched to see which ones got out. They used the same approach to see the effects of tumor shrinkage.

Even if drugs are designed that can get through pores, they will face an uphill battle once they get inside a tumor. The pressure exerted by the material surrounding tumor cells, called the interstitium, is enormous, as Jain and his colleagues have recently shown. Jain believes that there are ways around such obstacles. For example, it may be possible to lower pressure by draining the interstitium inside tumors. In fact, Jain and his colleagues are currently working on such a tumor drain. "We are trying to understand and modify the barriers more and more," he says.

The research was funded in part by the National Cancer Institute and the National Institutes of Health.

Editors: A two-color graphic that helps illustrate this research is availab
'"/>

Contact: Bill Schaller
schaller@hms.harvard.edu
617-432-0441
Harvard Medical School
14-Apr-1998


Page: 1 2 3 4

Related medicine news :

1. Successful therapy for head and neck cancer may lead to long-term circulatory problems
2. Successful, rapid protein crystallization possible with technique developed by UCSD researcher
3. Successful prostate surgery: Its quality of surgery not quantity that matters most
4. Successful implementation of pilot study for HIV antiretroviral therapy in Uganda
5. Successful measles vaccination feasible in low-income countries
6. New Procedure Makes A Successful Transplant Possible
7. Patients Treated Successfully For Hodgkins Disease Are At 9 Times The Risk For Developing Second Cancer
8. Vaccine Against Melanoma Proves Successful For Patients With Disease Spread To Two Lymph Node Areas
9. NHLBI Clinical Trial Stopped Early: Successful Ventilator Strategy Found For Intensive Care Patients On Life Support
10. Magnetic Surgery System Tested Successfully On First Patient
11. Successful Atherosclerosis Treatment Program

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... , ... September 17, 2019 , ... ... availability of the newly updated International Audit Protocol Consortium (IAPC) EHS audit protocol ... protocols to understand the scope of their EHS regulatory obligations and rapidly collect, ...
(Date:9/14/2019)... ... September 13, 2019 , ... ... studies on the detection and treatment of infectious diseases at its annual ... studies were noninvasive detection of residual HIV infected cell persistence and the ...
(Date:9/11/2019)... , ... September 11, 2019 , ... A September 2 ... had undergone weight loss surgery were significantly less likely to suffer heart attacks, strokes, ... not undergo bariatric surgery. Los Angeles-based weight loss surgery specialists Dr. Feiz and Associates ...
(Date:9/11/2019)... ... , ... Autopsies don’t lie. They report the causes of death as ... harms the heart. It increases risks of heart attack and death. Autopsies ... damage occurs. , An August 1, 2019 article in U.S. News ...
(Date:9/11/2019)... (PRWEB) , ... September 10, 2019 , ... ... to the team. Dr. Hesano is an understanding, caring and highly skilled Obstetrician/Gynecologist. ... high-risk obstetrical medicine. Dr. Hesano strives to ensure that each visit is comfortable, ...
Breaking Medicine News(10 mins):
(Date:9/17/2019)... Calif. (PRWEB) , ... September 17, 2019 , ... Summer is a time for barbecues, ... is good for our teeth and gums. Dr. Douglas Ng, family dentist in San ... weather is the time for ice cream, and popsicles and ice-filled cold drinks to go ...
(Date:9/14/2019)... ... 13, 2019 , ... Corey Stern , a partner at Levy Konigsberg, ... Archibald over at least 3 decades while employed by Rockefeller University Hospital (“RUH”). ... Court - Southern District of New York, No. 1:19-cv-01403), the first case filed against ...
(Date:9/14/2019)... ... September 14, 2019 , ... On ... with peritoneal mesothelioma, a jury in Middlesex County found Johnson & Johnson liable ... alleging their mesotheliomas were caused by asbestos-containing J&J talc products. , ...
Breaking Medicine Technology:
Cached News: