Successful Cancer Therapy May Doom Later Treatments To Failure


Shimmying through shrinking blood vessel pores is just one of many challenges facing drug agents. Ten years ago, Jain showed that just getting into the blood supply surrounding the tumors is a difficult task. "Nobody had measured resistance to blood flow in tumor vessels before. It was like walking into a wide open field," he says. Jain and his colleagues showed that the capillaries, arteries, and veins surrounding tumors are a jumbled mass -- thick in some areas and pinched at others -- rather than a neat and orderly array. And to make navigation even more difficult, the blood flowing through them is highly viscous -- more like sludge than water.

Blood vessels surrounding tumors are also known to be very leaky in some areas but not in others. It was only recently with the development of his immune-deficient mouse model that Jain was able to grow enough kinds of tumors to tackle the question of blood vessel pores systematically. He and his colleagues injected fluorescently labeled particles of increasing size in to the blood vessels of the six tumors at various locations and watched to see which ones got out. They used the same approach to see the effects of tumor shrinkage.

Even if drugs are designed that can get through pores, they will face an uphill battle once they get inside a tumor. The pressure exerted by the material surrounding tumor cells, called the interstitium, is enormous, as Jain and his colleagues have recently shown. Jain believes that there are ways around such obstacles. For example, it may be possible to lower pressure by draining the interstitium inside tumors. In fact, Jain and his colleagues are currently working on such a tumor drain. "We are trying to understand and modify the barriers more and more," he says.

The research was funded in part by the National Cancer Institute and the National Institutes of Health.

Editors: A two-color graphic that helps illustrate this research is availab

Contact: Bill Schaller
Harvard Medical School

Page: 1 2 3 4

Related medicine news :

1. Successful therapy for head and neck cancer may lead to long-term circulatory problems
2. Successful, rapid protein crystallization possible with technique developed by UCSD researcher
3. Successful prostate surgery: Its quality of surgery not quantity that matters most
4. Successful implementation of pilot study for HIV antiretroviral therapy in Uganda
5. Successful measles vaccination feasible in low-income countries
6. New Procedure Makes A Successful Transplant Possible
7. Patients Treated Successfully For Hodgkins Disease Are At 9 Times The Risk For Developing Second Cancer
8. Vaccine Against Melanoma Proves Successful For Patients With Disease Spread To Two Lymph Node Areas
9. NHLBI Clinical Trial Stopped Early: Successful Ventilator Strategy Found For Intensive Care Patients On Life Support
10. Magnetic Surgery System Tested Successfully On First Patient
11. Successful Atherosclerosis Treatment Program

Post Your Comments:

(Date:6/20/2019)... ... June 20, 2019 , ... SightMD (or the ... Founders, announced a strategic partnership with Northern Westchester Ophthalmology, P.C. (“NWO”) and its ... in New York, adding the Company’s first location in Westchester County to SightMD’s ...
(Date:6/19/2019)... ... 19, 2019 , ... The number of public health departments ... of performance continues to climb. Today, the Public Health Accreditation Board ... public health departments. With this week's accreditation decisions, tens of thousands more people ...
(Date:6/19/2019)... ... June 19, 2019 , ... The ... Congress (IRC) in Marseille, France. The conference is widely seen as the ... muscular dystrophy (FSHD). Nearly 200 researchers, clinicians, industry representatives and patient advocates are ...
(Date:6/18/2019)... ... June 18, 2019 , ... EMulate Therapeutics, Inc. ... serious diseases, announced it has received notice that the US Food and Drug ... (HDE) for the Hælo Pediatric system. The FDA granted the Humanitarian Use ...
(Date:6/18/2019)... ST. LOUIS (PRWEB) , ... June 18, 2019 ... ... cost, quality and clinical outcomes, today announced Steve Einig has joined the organization ... will lead strategy and corporate initiatives around market engagement, marketing, strategic events and ...
Breaking Medicine News(10 mins):
(Date:6/20/2019)... ... June 20, 2019 , ... Phlexglobal today announced an important industry advisory around ... effect on June 6, 2019, and promises to have far-reaching impacts on an organization’s ... , At 17 pages and going into specific detail – unusual for most guidance ...
(Date:6/19/2019)... ... June 19, 2019 , ... Mahendra Kumar ... Thermal and Physical Properties of Biofield Treated Bile Salt and Proteose Peptone became ... Biophysics, Preventive Medicine, Biochemistry, Medical Technology, Pathophysiology, Molecular Biology, Science Reference and 45-Minute ...
(Date:6/19/2019)... SAN LUIS OBISPO, Calif. (PRWEB) , ... June 19, 2019 , ... “We sometimes take ... daily brushing and flossing, and regular checkups we seldom think about our teeth unless it’s ... , Our teeth help us chew, speak, smile and have a very important role in ...
Breaking Medicine Technology:
Cached News: