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'Super' aspirin and clot buster drug may help heart attack victims avoid surgery

reated with one of four therapies; alteplase, alone, abciximab alone or abciximab with reduced doses of alteplase.

Each patient received an angiogram, a visualization of the blood vessels that uses X-rays to determine how quickly the drugs dissolved blood clots in the vessel. The study examined the ability of the drugs to dissolve blood clots within 60 and 90 minutes. The study showed that 72 percent of heart attack victims who received abciximab plus half the standard dose of alteplase achieve optimal blood flow in their arteries within 60 minutes of treatment compared with only 43 percent of patients treated with alteplase alone. Within 90 minutes, 77 percent of patients treated with combination therapy achieved this level of blood flow, compared with 62 percent given alteplase alone.

Clot-buster drugs currently are the standard therapy for treating heart attacks. However, they are not always effective and many individuals develop recurrent blood clots.

"By enhancing the effects of clot-busters, abciximab may improve the treatment for heart attacks, and allow more patients to be treated with drugs rather than angioplasty and surgery," says Antman.


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Contact: Carole Bullock
caroleb@heart.org
214-706-1279
American Heart Association
1-Jun-1999


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