Men and women who had good childhoods and good marriages scored considerably better on a measure of aging that includes a broad range of biological risk factors for disease and death.

Individual components of the measure, known as allostatic load, include blood pressure, cholesterol levels, blood sugar metabolism and hormonal levels. Those components often do not significantly affect health outcomes, but assessing them together has been shown to predict risk for disease and death, says lead author Teresa E. Seeman, Ph.D., of the UCLA School of Medicine.

Wear and tear across multiple physiological systems is consistent with evidence that many people, particularly at later ages, suffer from multiple, co-occurring chronic conditions, she says.

The study included a younger cohort of 106 men and women from the Wisconsin Longitudinal Study who were most recently interviewed at age 58 to 59, as well as an older cohort of nearly 1,200 participants in the MacArthur Studies of Successful Aging who were between ages 70 and 79.

The researchers found that allostatic load was generally higher in the older group of men and women, consistent with the idea that allostatic load represents the normal wear and tear of aging.

Men and women who had a lot of supportive friends were much more likely to score low for allostatic load than those with two or fewer close friends. Women, and to a lesser extent men, also seemed to benefit from good relationships with their parents and spouses.

Relationships likely affect a range of biological systems as cognitive and emotional qualities of social experiences are translated by the brain to downstream patterns of physiological activity, she says.

There was also a limited effect in the opposite
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Contact: Rachel Champeau
rchampeau@support.ucla.edu
310-794-2270
Center for the Advancement of Health
23-May-2002