HOME >> MEDICINE >> NEWS
Survival benefit for rheumatoid arthritis patients treated with methotrexate

The anticancer drug methotrexate could have a substantial survival benefit among patients with rheumatoid arthritis, conclude authors of a prospective US study in this weeks issue of THE LANCET.

Rheumatoid arthritis is a chronic inflammatory disease which results in reduced life-expectancy and is associated with cardiovascular disease, infection, and cancer. Low-dose methotrexate is the main choice of antirheumatic therapy for rheumatoid arthritis, although its effect on mortality for patients with the disease is not known.

Hyon Choi from Harvard Medical School and Harvard School of Public Health, Frederick Wolfe from University of Kansas School of Medicine, USA, and colleagues prospectively studied 1240 patients with rheumatoid arthritis over the past two decades. 191 individuals died during follow-up. Patients who began treatment with methotrexate (around half of the study population) had more severe rheumatoid arthritis. After adjustment for this confounding factor, methotrexate was found to have a 60% survival benefit for all-cause mortality compared with those who did not use methotrexate, and a 70% survival benefit for cardiovascular death.

Hyon Choi comments: Our data indicate that methotrexate may provide a substantial survival benefit, largely by reducing cardiovascular mortality. This gain in life expectancy could be considered in selecting a cost-effective, disease-modifying antirheumatic drug on a long-term basis. Additionally, the survival benefit of methotrexate would set a standard against which new disease-modifying antirheumatic drugs should be compared.


'"/>

Contact: Richard Lane
richard.lane@lancet.com
44-0-20-7424-4949
Lancet
4-Apr-2002


Page: 1

Related medicine news :

1. Survival sex and substance abuse may hinder HIV prevention efforts
2. Survival improves in clinical trial for severe birth defect, with or without fetal surgery
3. Abgenix Reports Positive Survival Data From A Phase II Trial Of ABX-CBL In Graft Versus Host Disease
4. American Heart Association Comment: Contributions Of Trends In Survival And Coronary-Event Rates To Changes In Coronary Heart Disease Mortality
5. Early Heart Repair For Marfan Syndrome Patients Critical To Survival
6. Intensive Care Before A Major Op May Improve Survival
7. Sex And Survival: In Some Matters Of The Heart Women Have The Edge
8. Study: Birth Defects Decrease Survival, Childbirth, Boost Risk Of Similar Defects
9. Study Indicates That Medicare Costs Are Higher -- And Survival Rate Is Better --At Major Teaching Hospitals Survive Climate Change
10. Maxim Phase II Clinical Trial Highlights Substantial Increase In Leukemia-FreeSurvival For Acute Myelogenous Leukemia Patients
11. Beta Blocker Significantly Improves Heart Failure Survival

Post Your Comments:
(Date:3/2/2015)... 02, 2015 Dr. David Knepp, a ... partnering with Doctors on Liens to bring ... It’s rare for personal injury victims to have access ... on a lien basis. However, San Diego Chiropractic ... of chiropractors, M.D., pain management physician, massage, and acupuncture ...
(Date:3/2/2015)... 1% for the Planet , one of ... over 25 new business members at this year’s Expo West ... 1% for the Planet welcomes them and more, including Boulder ... nut butter line. , Food - how we grow ... continues to be a complex environmental issue throughout the country ...
(Date:3/2/2015)... 02, 2015 Ticket Down is a ... Hollywood Bowl . This popular site has reduced all ... code JIMMY-BUFFETT-2015 for added savings. , Parrotheads in the ... will be headlining at the Hollywood Bowl for the ... on Thursday, October 22nd and it will be in ...
(Date:3/2/2015)... 02, 2015 Tyrone Christopher, Co-founder of ... medium for the model agency industry, have launched Softcandy.sexy, ... Mango, Passion Fruit, Pink Grapefruit, Pomegranate, and or Vanilla ... 1pm. , At a cost of alienating a few ... fire by announcing the brands commitment and support of ...
(Date:3/2/2015)... 2015 Robins & Morton Celebrates Women ... Women in Construction Week (March 1-7, sponsored by the ... National Women’s History Month, Robins & Morton is recognizing ... company and the construction industry as a whole. From ... dozens of roles in between, each woman has a ...
Breaking Medicine News(10 mins):Health News:Distinguished Doctor Brings His Multi-Specialty Medical Group to Doctors on Liens in San Diego 2Health News:1% For the Planet Members Shine Light on Food as Environmental Issue at Expo West 2Health News:1% For the Planet Members Shine Light on Food as Environmental Issue at Expo West 3Health News:Cheap Jimmy Buffett Tickets Hollywood Bowl: Ticket Down Slashes Prices on Jimmy Buffett Tickets at the Hollywood Bowl in Los Angeles/Hollywood, CA 2Health News:Sex Sells! A Newly Minted Organic Bodycare Brand Courts Controversy at a Cost 2Health News:Robins & Morton Recognizes Women In Construction 2
(Date:3/2/2015)... N.J. , March 2, 2015 BD ... a leading global medical technology company, today announced the ... Diego -based medical technology company dedicated to improving ... acquisition furthers BD,s position in helping address preventable medication ... and CRISI entered into an exclusive partnership in June ...
(Date:3/2/2015)... March 2, 2015  Akron Children,s Hospital has been ... the American College of Radiology (ACR), making it the ... the second children,s hospital in the United ... "Earning recognition from the ACR as a DICOE ... highest level compared with national benchmarks," says Dr. ...
(Date:3/2/2015)... 2, 2015  Sarnova, parent company of Tri-anim ... new www.tri-anim.com website, continuing Tri-anim,s mission ... of respiratory, anesthesia and other critical care supplies ... The site has many new features and enhanced ... shopping and ordering easier and more efficient for ...
Breaking Medicine Technology:BD Acquires CRISI Medical Systems 2BD Acquires CRISI Medical Systems 3Akron Children's designated ACR Diagnostic Imaging Center of Excellence 2Tri-anim Health Services Launches New Website Featuring Improved Product Selection and Ease of Ordering 2Tri-anim Health Services Launches New Website Featuring Improved Product Selection and Ease of Ordering 3
Cached News: