Synthetic progestin damages, estrogen protects blood vessels in animal model

TAMPA (11 Dec 2003) -- Synthetic progestins may be the major cause of harmful side effects reported with hormone replacement therapy. University of South Florida researchers used a novel imaging technique to show that progestins caused toxicity while natural progesterone and estrogen did not show toxicity to blood vessels in live animals.

"Our findings can lead to the development and screening of synthetic hormones to find a safe progestin that will ultimately give women safer options than are currently available for hormone replacement therapy," said Tom Thomas, MD, PhD, co-principal investigator and lead author of the study published today in Climacteric, the Journal of the International Menopause Society.

"This is experimental evidence that supports scientists who believe estrogen with the right formulation is good for some women, depending on their other risk factors."

The novel imaging technique was developed by Thomas and Johannes Rhodin, MD, PhD, co-principal investigator. It took three years for Thomas and Rhodin to combine video microscopy with fluorescence and electron microscopy. By labeling blood cells with a fluorescent tag, the team observed blood flow, blood vessel structure and activities of various blood cells in real time in a live animal. After one dose of medroxy progesterone acetate (MPA), the most widely used synthetic progestin in estrogen prepaparations and oral contraceptives, the rats had visible damage to the periphery and brain blood vessels, endothelial and smooth muscle damage, inflammation and blood clot formation and impeded blood flow.

These vascular reactions to synthetic progestin can lead to increases in heart attacks, blood clots, strokes and dementia--problems that were observed in the Women's Health Initiative," Thomas said.

The USF researchers' findings may shed light on the current reassessment of the National Institute of Health-sponsored Women's Health Initiative.

Using the sa

Contact: Marissa Emerson
University of South Florida Health

Page: 1 2

Related medicine news :

1. Synthetic marijuana reduces agitation in patients with Alzheimers
2. Synthetic marijuana compound reduces agitation, improves appetite in Alzheimers patients
3. Synthetic rubber kills germs on contact
4. Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
5. UCSF Study In Rats Suggests Synthetic Drug Mimicking Marijuana Might Be Used To Treat Pain
6. "Green Chemistry" Cleans Up Environment And Renders Synthetic Drugs
7. Synthetic Detergent Found To Fight Multi-Drug Resistance
8. Estrogren plus progestin decreases colorectal cancer in postmenopausal woman
9. High estrogen/progestin levels may reduce asthma severity, say Pittsburgh researchers
10. Changing chemistry helps explain estrogen threat to the heart
11. Use of estrogen therapy may increase risk for gallbladder disease

Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... According to an article published ... that they are handling security in light of the recent terrorist attacks in Paris, ... attempt to stop an attack from reaching U.S. soil. Especially around special events that ...
(Date:11/27/2015)... ... 2015 , ... A team of Swiss doctors has released a report on ... just posted the findings on the website. Click here to read the details ... mesothelioma patients who were treated with chemotherapy followed by EPP surgery. Among the 106 ...
(Date:11/27/2015)... ... November 27, 2015 , ... "When I was traveling, I ... Hillside, N.J. "Many people catch diseases simply from sitting on such dirty toilet ... protected from germs." , He developed the patent-pending QUDRATECS to eliminate the need ...
(Date:11/27/2015)... ... November 27, 2015 , ... The print component ... Today in Atlanta, Dallas, New York, Minneapolis, South Florida, with a circulation of ... distributed nationally, through a vast social media strategy and across a network of ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, ... Table 1-1 ). More than 3.7 billion people under the age of 50 – ... according to WHO's first global estimates of HSV-1 infection . , "The data shocks ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Therapeutic Drug Monitoring (TDM) Market: Supplier ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Cell Surface Marker ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
(Date:11/25/2015)...  Linden Care, LLC, a retail specialty pharmacy focused ... suffering from chronic pain, said today that it is ... (TRO) enjoining Express Scripts from unilaterally terminating the Pharmacy ... --> --> The company said that ... --> --> In ...
Breaking Medicine Technology:
Cached News: