Taking pills, even if placebo, predicts better survival in heart failure

DURHAM, N.C. -- In findings that can not totally be explained but are sure to lead to future research, Duke Clinical Research Institute investigators have found that adherence to medical therapy, even if the medication is an inert placebo, relates to better outcomes for heart failure patients.

This finding persisted even after the researchers statistically controlled for a wide variety of patient and treatment characteristics. The researchers also said that their findings do not appear to be a statistical quirk because of the large numbers of patients involved and the length of follow-up in the clinical trial that served as the basis for their analysis.

In an international clinical trial of 7,599 heart failure patients, the researchers found that good adherence was associated with similar lower mortality rates for both the placebo and an angiotensin receptor blocker (ARB), a medication used to relax and dilate blood vessels, when compared to patients who were not as adherent. Also, good adherence was associated with lower rates of hospitalization for both placebo and active drug.

"Adherence to medications is one of the most important predictors of clinical outcomes for patients with complex diseases like heart failure," said Bradi Granger, Ph.D., who presented the results of the Duke analysis Nov. 9, 2004, at the American Heart Association's annual scientific sessions in New Orleans.

"Our finding that adherence to a placebo was an important and independent predictor of better outcomes suggests that adherence itself is a marker for other unmeasured variables that can determine outcome," Granger continued. "Understanding these factors may provide an opportunity for novel interventions, including those targeted at improving adherence."

Also known as congestive heart failure, heart failure is a condition characterized by the thickening of the walls of the heart. Over time this thickening restricts the heart's ability to pump enoug

Contact: Richard Merritt
Duke University Medical Center

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