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Taking pills, even if placebo, predicts better survival in heart failure

proving adherence should help patients avoid frequent hospitalization and improve survival. Such strategies as calling or mailing reminders to patients about taking their medications, involving friends or family members their care, or simplifying the drug regimen have been shown to improve compliance, Granger said.

"These strategies can be effective, but they are expensive and labor-intensive," Granger said. "It would be helpful if we could determine what characteristics predict non-adherence, and so could target our efforts toward that population of patients."

The CHARM trial was funded by AstraZeneca, Mondal, Sweden. Granger's analysis was supported by the Duke Clinical Research Institute.

Other members of the team were Karl Sedberg and Inger Ekman, Sahlgrenska University Hospital, Goteborg, Sweden; Jan Ostergren, Karolinska Hospital, Stockholm, Sweden; Salim Yusuf, McMaster University, Hamilton, Ontario; Eric Michelson, AstraZeneca; Christopher Granger, Duke; and Marc Pfeffer, Brigham & Women's Hospital, Boston.


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Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
9-Nov-2004


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