Taking vitamins to lower amino acid level in blood does not reduce the risk of recurr...( 8.0 percent in the high-dose group and ...),Health

However, the authors did discover that "there was a persistent and graded association between baseline total homocysteine level and outcomes. A 3-micromol/liter lower total homocysteine level was associated with a 10 percent lower risk of stroke, a 26 percent lower risk of CHD events, and a 16 percent lower risk of death in the low-dose group and a nonsignificantly lower risk in the high-dose group by 2 percent for stroke, 7 percent for CHD events, and 7 percent for death."

"In summary, [this] trial showed that moderate reduction of total homocysteine level after ischemic stroke had no effect on vascular outcomes during the 2 years of follow-up. However, because of the consistent findings of an association of total homocysteine level with vascular risk, further exploration of the hypothesis is warranted and longer trials in different populations with elevated total homocysteine may be necessary," the researchers conclude.

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Contact: Jonnie Rohrer
336-716-6972
JAMA and Archives Journals
3-Feb-2004