HOME >> MEDICINE >> NEWS
Tamoxifen and estrogen have similar effects on the brain

A new study suggests that neither tamoxifen nor estrogen has a negative impact on brain chemistry in elderly women. These findings may quell concerns about the safety of using tamoxifen to reduce breast cancer risk in elderly women, say Thomas Ernst, Ph.D., of Brookhaven National Laboratory in New York, and coworkers from the Harbor-UCLA Research and Education Institute in Torrance, Calif., in the April 17 issue of the Journal of the National Cancer Institute.

Past studies have suggested that estrogens may improve brain functioning, possibly by blocking neural cell death caused by oxidation. However, some studies have suggested that tamoxifen, which blocks estrogens stimulatory effects in breast cancer, may block estrogens beneficial effects on the brain and possibly contribute to cognitive decline.

To study tamoxifens effect on brain chemistry in elderly women, Ernst and his coworkers used a brain imaging technique to compare levels of myo-inositol, a chemical that increases in response to brain injury, among 16 breast cancer survivors who had been treated with tamoxifen for at least 2 years, 27 healthy women who had been treated with preventive estrogen replacement therapy for at least 2 years, and 33 healthy women who had not received any treatment. All of the women were between the ages of 65 and 80 and did not have any neurologic diseases.

The researchers found that women who had been treated with tamoxifen had lower levels of myo-inositol in the brain than the untreated women. Women who took estrogen also had lower levels of the chemical. Myo-inositol levels were lowest among women who had been treated with tamoxifen for longer periods of time.

The authors conclude from the lower levels of myo-inositol in women treated with tamoxifen or estrogen that both [tamoxifen and estrogen] may be neuroprotective and may have favorable modulatory effects on aging. They note, however, that future studies are necessary to look at t
'"/>

Contact: Linda Wang
jncinews@oup-usa.org
301-841-1287
Journal of the National Cancer Institute
16-Apr-2002


Page: 1 2

Related medicine news :

1. Tamoxifens risks similar in African American and white women
2. Tamoxifen for prevention of breast cancer encouraging results but risks still unclear
3. Tamoxifen found to increase risk of endometrial cancer
4. Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
5. Changing chemistry helps explain estrogen threat to the heart
6. Use of estrogen therapy may increase risk for gallbladder disease
7. Decreased sensitivity in the brain to estrogen may help explain menopausal changes
8. Celecoxib shows surprising activity against estrogen receptors
9. Scientists identify key mechanism in estrogens role in preventing bone loss
10. New insights into hormone therapy highlight when estrogen best aids brain
11. High fiber intake reduces estrogen levels in Latina women, say Keck School of Medicine researchers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tamoxifen and estrogen have similar effects the brain

(Date:5/22/2015)... May 22, 2015 The American College ... events in June. They will hold a webinar on ... a two-day class on Classical Chinese Medicine. , Webinar ... Dr. Steve Given, the Dean of Clinical Education, will ... new First Professional Doctorate program. ACTCM is currently developing ...
(Date:5/22/2015)... New York, New York (PRWEB) May 22, 2015 ... ( http://www.xareltolawsuit2015.com/ ) filed on behalf of individuals ... complications due to its use continue to move ... of Louisiana. According to a Pretrial Order dated ... governing the preservation of documents and electronically stored ...
(Date:5/22/2015)... 22, 2015 Combination therapy, or ... for chronic obstructive pulmonary disorder (COPD) as the ... AstraZeneca plc as well as Germany’s Boehringer Ingelheim ... position. But will market payers, clinicians and patients ... products to completely new ones? , In spite ...
(Date:5/22/2015)... May 22, 2015 Family, friends, students, ... world-renowned surgical oncologist, Dr. LaSalle D. Leffall, on Monday, ... luncheon began after Grand Rounds in the hospital’s Tower ... anxiously outside the auditorium, trying to keep the secret. ... if he sees me, he’ll know something is up,” ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Memorial Day weekend ... Amica Insurance is offering some tips to help promote ... Council, there will be 383 traffic fatalities this Memorial Day ... the National Highway Traffic Safety Association: , ... the vehicle is wearing a seatbelt, whether they’re driving or ...
Breaking Medicine News(10 mins):Health News:ACTCM Announces Upcoming June Events 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4Health News:Chronic Obstructive Pulmonary Disorder Therapeutics Market Discussed in In-demand FirstWord Report Published at MarketPublishers.com 2Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2Health News:Amica Has 4 Road Safety Tips for Memorial Day Weekend 2
(Date:5/21/2015)... May 21, 2015  Cardica, Inc. (Nasdaq: CRDC ) ... Greg Watson , the company,s vice president of operations, was ... common stock, at a per share exercise price of $0.43, ... option was granted pursuant to Cardica, Inc.,s Inducement Plan, which ... 2015 under Rule 5653(c)(4) of the Nasdaq Global Market for ...
(Date:5/21/2015)... The Pharmaceutical Care Management Association (PCMA) ... D offsets included in the Energy & Commerce ... the 21st Century Cures initiative can only be advanced ... – Medicare – then its costs outweigh any ... "Leveraging payments to Part D plans ...
(Date:5/21/2015)... , May 21, 2015 ... Arzneimittelfälschungen - Zwecks Leistungsvergleich zur Expertise ... auf EG-Mitgliedstaaten verwiesen, in denen uneingeschränkt ... Wählen Sie ein Aegate-Land: beispielsweise BELGIEN ... zur Bekämpfung von Arzneimittelfälschungen (FMD) handelt ...
Breaking Medicine Technology:Cardica Announces New Employment Inducement Grant 2EU-Arzneimittel-Richtlinie für gefälschte Medikamente; Aegate-Zusammenfassung als reale Bewertung aus Belgien 2EU-Arzneimittel-Richtlinie für gefälschte Medikamente; Aegate-Zusammenfassung als reale Bewertung aus Belgien 3
Cached News: