HOME >> MEDICINE >> NEWS
Tamoxifen and estrogen have similar effects on the brain

A new study suggests that neither tamoxifen nor estrogen has a negative impact on brain chemistry in elderly women. These findings may quell concerns about the safety of using tamoxifen to reduce breast cancer risk in elderly women, say Thomas Ernst, Ph.D., of Brookhaven National Laboratory in New York, and coworkers from the Harbor-UCLA Research and Education Institute in Torrance, Calif., in the April 17 issue of the Journal of the National Cancer Institute.

Past studies have suggested that estrogens may improve brain functioning, possibly by blocking neural cell death caused by oxidation. However, some studies have suggested that tamoxifen, which blocks estrogens stimulatory effects in breast cancer, may block estrogens beneficial effects on the brain and possibly contribute to cognitive decline.

To study tamoxifens effect on brain chemistry in elderly women, Ernst and his coworkers used a brain imaging technique to compare levels of myo-inositol, a chemical that increases in response to brain injury, among 16 breast cancer survivors who had been treated with tamoxifen for at least 2 years, 27 healthy women who had been treated with preventive estrogen replacement therapy for at least 2 years, and 33 healthy women who had not received any treatment. All of the women were between the ages of 65 and 80 and did not have any neurologic diseases.

The researchers found that women who had been treated with tamoxifen had lower levels of myo-inositol in the brain than the untreated women. Women who took estrogen also had lower levels of the chemical. Myo-inositol levels were lowest among women who had been treated with tamoxifen for longer periods of time.

The authors conclude from the lower levels of myo-inositol in women treated with tamoxifen or estrogen that both [tamoxifen and estrogen] may be neuroprotective and may have favorable modulatory effects on aging. They note, however, that future studies are necessary to look at t
'"/>

Contact: Linda Wang
jncinews@oup-usa.org
301-841-1287
Journal of the National Cancer Institute
16-Apr-2002


Page: 1 2

Related medicine news :

1. Tamoxifens risks similar in African American and white women
2. Tamoxifen for prevention of breast cancer encouraging results but risks still unclear
3. Tamoxifen found to increase risk of endometrial cancer
4. Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
5. Changing chemistry helps explain estrogen threat to the heart
6. Use of estrogen therapy may increase risk for gallbladder disease
7. Decreased sensitivity in the brain to estrogen may help explain menopausal changes
8. Celecoxib shows surprising activity against estrogen receptors
9. Scientists identify key mechanism in estrogens role in preventing bone loss
10. New insights into hormone therapy highlight when estrogen best aids brain
11. High fiber intake reduces estrogen levels in Latina women, say Keck School of Medicine researchers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tamoxifen and estrogen have similar effects the brain

(Date:3/4/2015)... 2015 The defibrillators report provides insights ... to the report the global market is expected to ... reach $12.9 billion by 2019. It expects the emerging ... as well as established players in the market. , ... to witness growth at the highest CAGR during the ...
(Date:3/4/2015)... 04, 2015 TheraBreath is proud to announce ... breath, could also help with overall health. , Many ... may help ward off bad bacteria that can cause unwanted ... on their own, most will need the help of a ... germ fighting levels. , Packed with the S. salivarius M18 ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 ... is witnessing strong growth worldwide, supported by the ... of robot-assisted surgery and single incision surgery will ... benefits of minimally invasive surgery, driving its adoption ... to the surgical site, lower blood loss, shorter ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 Durrie ... practice, is the first in the region to offer ... for presbyopia and cataracts. The implantable Tecnis® Multifocal lenses ... to improve vision at a range of distances. Earlier ... approved the use of two new IOLs – the ...
(Date:3/4/2015)... From the halls of the International Association ... AvePoint, the established leader in enabling enterprise ... AvePoint Risk Intelligence System (ARIS) to allow organizations ... enterprise. , Leveraging the templates and question banks created ... system – used by more than 2,000 practitioners today ...
Breaking Medicine News(10 mins):Health News:Defibrillators Market worth $12.9 Billion by 2019 with Rise in Aging Population - New Research Report by MarketsandMarkets 2Health News:Defibrillators Market worth $12.9 Billion by 2019 with Rise in Aging Population - New Research Report by MarketsandMarkets 3Health News:TheraBreath introduces a new line of probiotic lozenges that strengthen the body’s ability to fight germs 2Health News:Growing Demand for Less Invasive Procedures Drives Growth in the Endoscopy Systems Market, According to a New Report by Global Industry Analysts, Inc. 2Health News:Growing Demand for Less Invasive Procedures Drives Growth in the Endoscopy Systems Market, According to a New Report by Global Industry Analysts, Inc. 3Health News:Growing Demand for Less Invasive Procedures Drives Growth in the Endoscopy Systems Market, According to a New Report by Global Industry Analysts, Inc. 4Health News:Durrie Vision First in Region to Offer New Tecnis® Multifocus Lenses 2Health News:AvePoint Unveils New Solution to Address the Complete Risk Lifecycle at IAPP Global Privacy Summit 2015 2Health News:AvePoint Unveils New Solution to Address the Complete Risk Lifecycle at IAPP Global Privacy Summit 2015 3Health News:AvePoint Unveils New Solution to Address the Complete Risk Lifecycle at IAPP Global Privacy Summit 2015 4
(Date:3/3/2015)... , March 3, 2015 Medical Tracking ... announce the hiring of Brian Timberlake ... business development efforts and build relationships with existing ... in software development, sales, and sales management as ... applications. iTraycer is a comprehensive inventory management system ...
(Date:3/3/2015)... March 3, 2015  Cumberland Pharmaceuticals Inc. (NASDAQ: ... on hospital acute care and gastroenterology, today announced ... Company,s revenue grew 15% in 2014 to $37 ... or $0.35 per diluted share. At the end ... $95 million including $55 million in cash and ...
(Date:3/3/2015)... , March 3, 2015  This industry report package offers the most ... for safety glass in the world and in the top 10 global ... country reports from the following countries: Australia ... Germany , Italy , Japan ... United Kingdom , United States ...
Breaking Medicine Technology:Medical Tracking Solutions, Inc. Hires New SVP, Sales 2Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 2Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 3Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 4Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 5Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 6Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 7Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 8Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 9Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 10Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 11Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 12Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 13Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 14Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 15Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 16Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 17Cumberland Pharmaceuticals Announces Return To Growth And Profitability In 2014 18Global Safety Glass Market to 2019 - Market Size, Top 10 Countries, Trends, and Forecasts 2
Cached News: