HOME >> MEDICINE >> NEWS
Tamoxifen and estrogen have similar effects on the brain

A new study suggests that neither tamoxifen nor estrogen has a negative impact on brain chemistry in elderly women. These findings may quell concerns about the safety of using tamoxifen to reduce breast cancer risk in elderly women, say Thomas Ernst, Ph.D., of Brookhaven National Laboratory in New York, and coworkers from the Harbor-UCLA Research and Education Institute in Torrance, Calif., in the April 17 issue of the Journal of the National Cancer Institute.

Past studies have suggested that estrogens may improve brain functioning, possibly by blocking neural cell death caused by oxidation. However, some studies have suggested that tamoxifen, which blocks estrogens stimulatory effects in breast cancer, may block estrogens beneficial effects on the brain and possibly contribute to cognitive decline.

To study tamoxifens effect on brain chemistry in elderly women, Ernst and his coworkers used a brain imaging technique to compare levels of myo-inositol, a chemical that increases in response to brain injury, among 16 breast cancer survivors who had been treated with tamoxifen for at least 2 years, 27 healthy women who had been treated with preventive estrogen replacement therapy for at least 2 years, and 33 healthy women who had not received any treatment. All of the women were between the ages of 65 and 80 and did not have any neurologic diseases.

The researchers found that women who had been treated with tamoxifen had lower levels of myo-inositol in the brain than the untreated women. Women who took estrogen also had lower levels of the chemical. Myo-inositol levels were lowest among women who had been treated with tamoxifen for longer periods of time.

The authors conclude from the lower levels of myo-inositol in women treated with tamoxifen or estrogen that both [tamoxifen and estrogen] may be neuroprotective and may have favorable modulatory effects on aging. They note, however, that future studies are necessary to look at t
'"/>

Contact: Linda Wang
jncinews@oup-usa.org
301-841-1287
Journal of the National Cancer Institute
16-Apr-2002


Page: 1 2

Related medicine news :

1. Tamoxifens risks similar in African American and white women
2. Tamoxifen for prevention of breast cancer encouraging results but risks still unclear
3. Tamoxifen found to increase risk of endometrial cancer
4. Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
5. Changing chemistry helps explain estrogen threat to the heart
6. Use of estrogen therapy may increase risk for gallbladder disease
7. Decreased sensitivity in the brain to estrogen may help explain menopausal changes
8. Celecoxib shows surprising activity against estrogen receptors
9. Scientists identify key mechanism in estrogens role in preventing bone loss
10. New insights into hormone therapy highlight when estrogen best aids brain
11. High fiber intake reduces estrogen levels in Latina women, say Keck School of Medicine researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... December 08, 2016 , ... David J. Dykeman , ... Greenberg Traurig, LLP, will speak at DeviceTalks West, Dec. 12, 2016, at the Fairmont ... and attorneys from the firm’s global Life Sciences & Medical Technology Group have been ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView Software aims ... employees that are both engaging and easy to use. Coming off the heels ... company revealed today its plans to roll out new AI-powered self-service enhancements to ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... development solutions for drugs, biologics and consumer health products, today announced that it ... up in 2006 as a non-profit organization to unite pharmaceutical and healthcare companies ...
(Date:12/8/2016)... ... December 08, 2016 , ... STAT courier is pleased to announce ... service for Texas, they are expanding their presence in Dallas. One of the most ... will bring new jobs to the Dallas and Forth Worth market. STAT takes pride ...
(Date:12/8/2016)... Peachtree City, Ga (PRWEB) , ... December 08, ... ... and moving as soon after surgery as possible. With this in mind, SIGVARIS ... vein thrombosis (DVT or blood clot) during bed rest and provide the benefits ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 8, 2016 IRIDEX Corporation (NASDAQ: IRIX ... shares of common stock, $0.01 par value (the "Offering" with ... offering.  The final terms of the Offering will depend on ... there can be no assurance as to whether or when ... use the net proceeds it will receive from this offering ...
(Date:12/8/2016)... 8, 2016 KEY FINDINGS ... Patient warming and ... blood during surgeries, lowering the risks of neurological disorders post ... SSIs. The patient warming systems can be segmented into convective ... in turn reduce the stay at hospitals thus, lowering the ...
(Date:12/8/2016)... , Dec. 8, 2016 KEY FINDINGS ... poised to grow in 2017-2023. Various reasons for growth ... obese population, higher incidences of chronic diseases, high recovery ... mobility aid services. Medical lifting sling refers to ... with limited mobility. These slings connect to the lift ...
Breaking Medicine Technology:
Cached News: