HOME >> MEDICINE >> NEWS
Tamoxifen and estrogen have similar effects on the brain

A new study suggests that neither tamoxifen nor estrogen has a negative impact on brain chemistry in elderly women. These findings may quell concerns about the safety of using tamoxifen to reduce breast cancer risk in elderly women, say Thomas Ernst, Ph.D., of Brookhaven National Laboratory in New York, and coworkers from the Harbor-UCLA Research and Education Institute in Torrance, Calif., in the April 17 issue of the Journal of the National Cancer Institute.

Past studies have suggested that estrogens may improve brain functioning, possibly by blocking neural cell death caused by oxidation. However, some studies have suggested that tamoxifen, which blocks estrogens stimulatory effects in breast cancer, may block estrogens beneficial effects on the brain and possibly contribute to cognitive decline.

To study tamoxifens effect on brain chemistry in elderly women, Ernst and his coworkers used a brain imaging technique to compare levels of myo-inositol, a chemical that increases in response to brain injury, among 16 breast cancer survivors who had been treated with tamoxifen for at least 2 years, 27 healthy women who had been treated with preventive estrogen replacement therapy for at least 2 years, and 33 healthy women who had not received any treatment. All of the women were between the ages of 65 and 80 and did not have any neurologic diseases.

The researchers found that women who had been treated with tamoxifen had lower levels of myo-inositol in the brain than the untreated women. Women who took estrogen also had lower levels of the chemical. Myo-inositol levels were lowest among women who had been treated with tamoxifen for longer periods of time.

The authors conclude from the lower levels of myo-inositol in women treated with tamoxifen or estrogen that both [tamoxifen and estrogen] may be neuroprotective and may have favorable modulatory effects on aging. They note, however, that future studies are necessary to look at t
'"/>

Contact: Linda Wang
jncinews@oup-usa.org
301-841-1287
Journal of the National Cancer Institute
16-Apr-2002


Page: 1 2

Related medicine news :

1. Tamoxifens risks similar in African American and white women
2. Tamoxifen for prevention of breast cancer encouraging results but risks still unclear
3. Tamoxifen found to increase risk of endometrial cancer
4. Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
5. Changing chemistry helps explain estrogen threat to the heart
6. Use of estrogen therapy may increase risk for gallbladder disease
7. Decreased sensitivity in the brain to estrogen may help explain menopausal changes
8. Celecoxib shows surprising activity against estrogen receptors
9. Scientists identify key mechanism in estrogens role in preventing bone loss
10. New insights into hormone therapy highlight when estrogen best aids brain
11. High fiber intake reduces estrogen levels in Latina women, say Keck School of Medicine researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... ... 2017 , ... Hamlin Dental Group, multi-location dental office in North Hollywood ... lasers are safe and effective options, and can be used alone or in conjunction ... quality of care. , Dr. Hamid Reza of Hamlin Dental Group offers other treatments ...
(Date:3/29/2017)... NJ (PRWEB) , ... March 29, 2017 , ... ... School of Gastrointestinal Oncology™ (SOGO™), a specialized continuing medical education conference for clinicians ... 29 at Intercontinental Time Square, New York. , The program will be ...
(Date:3/29/2017)... ... 29, 2017 , ... AvePoint , the Microsoft Cloud expert, is pleased ... Virginia, located at the Riverfront Plaza, 901 East Byrd Street. AvePoint is celebrating with ... S. Northam and Mayor of Richmond Levar M. Stoney. , Founded in 2001, AvePoint ...
(Date:3/28/2017)... ... March 28, 2017 , ... A recent Bellwether ... teacher quality, the field must first improve teacher preparation program design. It then ... next” and that decades of input- and outcome-based research has failed to improve ...
(Date:3/28/2017)... ... March 28, 2017 , ... For many women, getting birth control isn’t as easy as it ... either don’t have access to a health care facility or a pharmacy within 60 minutes ... the United States or for many who are faced with health or personal issues that ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... March 29, 2017  Spiral Therapeutics, Inc. today ... Bionure Farma, S.L. for the worldwide exclusive rights ... in the field of otolaryngology for aggregate payments ... The agreement provides Spiral with the option ... differentiated product profile. Under the terms of the ...
(Date:3/29/2017)... AMSTERDAM , March 29, 2017   ... global leader in health technology, and PathAI, a ... are collaborating with the aim to develop solutions ... diagnosis of cancer and other diseases. The partnership ... pathology, enabling this form of artificial intelligence to ...
(Date:3/29/2017)... 29, 2017 Stryker announced today that it ... magazine, in partnership with Great Place to Work (GPTW). ... list. This list highlights the top U.S. companies with ... while also demonstrating respect, compassion and concern for their ... To determine the companies on the list, GPTW asked ...
Breaking Medicine Technology:
Cached News: