HOME >> MEDICINE >> NEWS
Tamoxifen and estrogen have similar effects on the brain

A new study suggests that neither tamoxifen nor estrogen has a negative impact on brain chemistry in elderly women. These findings may quell concerns about the safety of using tamoxifen to reduce breast cancer risk in elderly women, say Thomas Ernst, Ph.D., of Brookhaven National Laboratory in New York, and coworkers from the Harbor-UCLA Research and Education Institute in Torrance, Calif., in the April 17 issue of the Journal of the National Cancer Institute.

Past studies have suggested that estrogens may improve brain functioning, possibly by blocking neural cell death caused by oxidation. However, some studies have suggested that tamoxifen, which blocks estrogens stimulatory effects in breast cancer, may block estrogens beneficial effects on the brain and possibly contribute to cognitive decline.

To study tamoxifens effect on brain chemistry in elderly women, Ernst and his coworkers used a brain imaging technique to compare levels of myo-inositol, a chemical that increases in response to brain injury, among 16 breast cancer survivors who had been treated with tamoxifen for at least 2 years, 27 healthy women who had been treated with preventive estrogen replacement therapy for at least 2 years, and 33 healthy women who had not received any treatment. All of the women were between the ages of 65 and 80 and did not have any neurologic diseases.

The researchers found that women who had been treated with tamoxifen had lower levels of myo-inositol in the brain than the untreated women. Women who took estrogen also had lower levels of the chemical. Myo-inositol levels were lowest among women who had been treated with tamoxifen for longer periods of time.

The authors conclude from the lower levels of myo-inositol in women treated with tamoxifen or estrogen that both [tamoxifen and estrogen] may be neuroprotective and may have favorable modulatory effects on aging. They note, however, that future studies are necessary to look at t
'"/>

Contact: Linda Wang
jncinews@oup-usa.org
301-841-1287
Journal of the National Cancer Institute
16-Apr-2002


Page: 1 2

Related medicine news :

1. Tamoxifens risks similar in African American and white women
2. Tamoxifen for prevention of breast cancer encouraging results but risks still unclear
3. Tamoxifen found to increase risk of endometrial cancer
4. Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
5. Changing chemistry helps explain estrogen threat to the heart
6. Use of estrogen therapy may increase risk for gallbladder disease
7. Decreased sensitivity in the brain to estrogen may help explain menopausal changes
8. Celecoxib shows surprising activity against estrogen receptors
9. Scientists identify key mechanism in estrogens role in preventing bone loss
10. New insights into hormone therapy highlight when estrogen best aids brain
11. High fiber intake reduces estrogen levels in Latina women, say Keck School of Medicine researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... the heart of our nation’s productivity, stability, even security. Most importantly, employees are ... organizations. , Then why are American workers so unhappy? , Just under half ...
(Date:4/29/2016)... ... April 29, 2016 , ... The White House announced efforts ... more information about their loan terms and accounts, and more protections for borrowers. ... federal and private loans, has reached $1.3 trillion, with 43 million Americans holding ...
(Date:4/29/2016)... Stewart, GA (PRWEB) , ... April 29, 2016 , ... ... Monday, May 16, 2016, at its new location in the Exchange Furniture Mall at ... a raffle for a 50-inch Samsung Smart TV. Plus attendees will have the opportunity ...
(Date:4/29/2016)... ... ... Spine Team Texas, a comprehensive spine physician group specializing in the treatment ... been invited to be a featured speaker at the Texas Society of the American ... 2016. , Dr. R. Scott McPherson, a physical medicine and rehabilitation specialist, will ...
(Date:4/29/2016)... ... 2016 , ... Mobility Designed is redefining mobility with their patent pending ... Crutch evenly distributes body weight from the elbow to the forearm. In consumer ... than with other crutches. , Co-founders Max and Liliana Younger were inspired to design ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... , April 27, 2016  Bayer Animal Health ... senior from the University of Florida College of ... Bayer Excellence in Communication Award (BECA). Brittany was ... were awarded a total of $70,000 in scholarship ... four years, Bayer has provided a total of ...
(Date:4/27/2016)... 27, 2016 Global  urinalysis ... billion by 2022, according to a new report ... (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... efficiency and accuracy delivered by the new generation ... novel urinalysis instruments and consumables. For instance, the ...
(Date:4/26/2016)... Hill-Rom Holdings, Inc. (NYSE: HRC ) ... Deutsche Bank 41 st Annual Health Care Conference on ... You are invited to listen to the live discussion via ... directly at http://edge.media-server.com/m/p/mr4uxgas . A recorded replay of the ... live event and accessible at the links above until August ...
Breaking Medicine Technology:
Cached News: