Tamoxifen and estrogen have similar effects on...( he long-term effects of such therapies ...)

Tamoxifen and estrogen have similar effects on the brain

he long-term effects of such therapies on cognitive function.

In an accompanying editorial, Patricia A. Ganz, University of California Los Angeles Jonsson Comprehensive Cancer Center, and her colleagues write that, it is highly speculative to interpret [these findings] as indicative of neuroprotection. They note that it is important to consider alternative explanations for these results that take into account all of what we know about the physiologic effects of estrogen in women, as well as the relationship between lifelong exposure to estrogen and the risk for breast cancer.

Ganz and her coworkers point out that two ongoing studies, the Womens Health Initiative Memory Study trial and the Study of Tamoxifen and Raloxifene, may provide more definitive answers about the value of hormone replacement therapy as a neuroprotective agent. In a few years, we may have reliable information about the neurocognitive effects of estrogen and tamoxifen on the brain, the editorialists conclude.

'"/>

Contact: Linda Wang
jncinews@oup-usa.org
301-841-1287
Journal of the National Cancer Institute
16-Apr-2002

Page: 1 2
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