Tamoxifen found to increase risk of endometrial cancer

ings of other studies showing that tamoxifen increases the risk of uterine cancer; and most importantly, we have found that women who have used estrogens and who are overweight have the greatest risk when

using tamoxifen," Bernstein said. "Our results suggest that physicians should be particularly vigilant in monitoring tamoxifen-treated patients with these additional risk factors."

Bernstein noted that the risk of endometrial cancer must be balanced against tamoxifen's proven benefits in breast cancer treatment and its effectiveness in reducing the incidence of breast cancer among women at high risk for that cancer.

The researchers conducted the study with 324 patients with endometrial cancer who had previously been treated for breast cancer and 671 similar patients with breast cancer who did not develop endometrial cancer.


Contact: Alicia Di Rado
University of Southern California

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