HOME >> MEDICINE >> NEWS
Tamoxifen's risks similar in African American and white women

African American and white women who are treated with tamoxifen for breast cancer appear to have the same risks of contralateral breast cancer and thromboembolic events, according to a new study in the December 1 issue of the Journal of the National Cancer Institute.

Between 2% and 15% of women who have been diagnosed with breast cancer will develop contralateral breast cancer--cancer in the opposite breast--depending on age and other factors. Tamoxifen has been shown to reduce the risk of contralateral breast cancer by 47% in women with early-stage primary breast cancer. However, the trials that demonstrated tamoxifen's benefits were done largely in populations of white women, and little data exists on the drug's effects on African American women. In addition, tamoxifen use is associated with an increased risk of thromboembolic events, such as stroke, and the African American population has more risk factors--such as cardiovascular disease and diabetes--for these events compared with the white population.

To determine if there is a difference in the occurrence of contralateral breast cancers and thromboembolic events between African American and white women with breast cancer who are treated with tamoxifen, Worta McCaskill-Stevens, M.D., of the National Cancer Institute, and colleagues pooled data from 13 National Surgical Adjuvant Breast and Bowel Project clinical trials that had included more than 20,000 women.

In women from both ethnic groups who had estrogen-receptor (ER)-positive tumors, tamoxifen use was associated with a similar reduction in contralateral breast cancer. Tamoxifen use was also associated with a similar risk of thromboembolic events in both groups, and the risk of thromboembolic events was greater in women treated with both chemotherapy and tamoxifen compared with women treated with tamoxifen alone. Obesity and age were also risk factors for thromboembolic events. The authors conclude that tamoxifen is equally e
'"/>

Contact: Sarah Zielinski or Kate Travis
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
30-Nov-2004


Page: 1 2

Related medicine news :

1. Child care may affect entire communitys risks of infection
2. Short-term effects of spit tobacco suggest long-term health risks
3. Mayo Clinic study finds obese kidney donors face few increased risks
4. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
5. Study explores risks of obesity in children with kidney transplants
6. From town planning to intimate sex: Understanding the risks in our lives
7. More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
8. How to avoid the health risks of Hajj
9. Scientists study fish oil diet in bid to cut heart attack risks
10. Heart arrhythmias easily treated, yet few know risks
11. Maintaining stable weight, even in the obese, reduces heart risks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, ... Dallas, Miami, and Raleigh regions, is organizing an extended charity drive to benefit ... deadly chromosome abnormality. , After struggling since birth with several health challenges, T.J. ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's ... President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. ... 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... 13, 2017 , ... Ellevate Network, the leading network for professional women, brought ... gender equality at their inaugural Summit in New York City in June. The event ... audience of over 3 million. To watch the Mobilize Women video, click here ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader ... been awarded a contract by the Center for Medicare and Medicaid Services (CMS). ... the enterprise use of Agile methodologies in a consistent and high value manner ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 The Rebound mobile app is poised to ... the tide of prescription drug addiction. The app empowers users ... and stepping down their dosage in a safe, controlled manner ... 2017; the first 100,000 people to sign up will enjoy ... ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
(Date:9/19/2017)... Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, ... tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , PhD, ...
Breaking Medicine Technology:
Cached News: