HOME >> MEDICINE >> NEWS
Tamoxifen's risks similar in African American and white women

African American and white women who are treated with tamoxifen for breast cancer appear to have the same risks of contralateral breast cancer and thromboembolic events, according to a new study in the December 1 issue of the Journal of the National Cancer Institute.

Between 2% and 15% of women who have been diagnosed with breast cancer will develop contralateral breast cancer--cancer in the opposite breast--depending on age and other factors. Tamoxifen has been shown to reduce the risk of contralateral breast cancer by 47% in women with early-stage primary breast cancer. However, the trials that demonstrated tamoxifen's benefits were done largely in populations of white women, and little data exists on the drug's effects on African American women. In addition, tamoxifen use is associated with an increased risk of thromboembolic events, such as stroke, and the African American population has more risk factors--such as cardiovascular disease and diabetes--for these events compared with the white population.

To determine if there is a difference in the occurrence of contralateral breast cancers and thromboembolic events between African American and white women with breast cancer who are treated with tamoxifen, Worta McCaskill-Stevens, M.D., of the National Cancer Institute, and colleagues pooled data from 13 National Surgical Adjuvant Breast and Bowel Project clinical trials that had included more than 20,000 women.

In women from both ethnic groups who had estrogen-receptor (ER)-positive tumors, tamoxifen use was associated with a similar reduction in contralateral breast cancer. Tamoxifen use was also associated with a similar risk of thromboembolic events in both groups, and the risk of thromboembolic events was greater in women treated with both chemotherapy and tamoxifen compared with women treated with tamoxifen alone. Obesity and age were also risk factors for thromboembolic events. The authors conclude that tamoxifen is equally e
'"/>

Contact: Sarah Zielinski or Kate Travis
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
30-Nov-2004


Page: 1 2

Related medicine news :

1. Child care may affect entire communitys risks of infection
2. Short-term effects of spit tobacco suggest long-term health risks
3. Mayo Clinic study finds obese kidney donors face few increased risks
4. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
5. Study explores risks of obesity in children with kidney transplants
6. From town planning to intimate sex: Understanding the risks in our lives
7. More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
8. How to avoid the health risks of Hajj
9. Scientists study fish oil diet in bid to cut heart attack risks
10. Heart arrhythmias easily treated, yet few know risks
11. Maintaining stable weight, even in the obese, reduces heart risks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... Washington, D.C. (PRWEB) , ... June 25, 2016 ... ... will discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June ... share their work on several important health care topics including advance care planning, ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... ... Haute Living, is proud to recognize Dr. Barry M. Weintraub as a prominent ... “the most beautiful women in the world, and the most handsome men, look ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
Breaking Medicine Technology:
Cached News: