HOME >> MEDICINE >> NEWS
Tamoxifen's risks similar in African American and white women

African American and white women who are treated with tamoxifen for breast cancer appear to have the same risks of contralateral breast cancer and thromboembolic events, according to a new study in the December 1 issue of the Journal of the National Cancer Institute.

Between 2% and 15% of women who have been diagnosed with breast cancer will develop contralateral breast cancer--cancer in the opposite breast--depending on age and other factors. Tamoxifen has been shown to reduce the risk of contralateral breast cancer by 47% in women with early-stage primary breast cancer. However, the trials that demonstrated tamoxifen's benefits were done largely in populations of white women, and little data exists on the drug's effects on African American women. In addition, tamoxifen use is associated with an increased risk of thromboembolic events, such as stroke, and the African American population has more risk factors--such as cardiovascular disease and diabetes--for these events compared with the white population.

To determine if there is a difference in the occurrence of contralateral breast cancers and thromboembolic events between African American and white women with breast cancer who are treated with tamoxifen, Worta McCaskill-Stevens, M.D., of the National Cancer Institute, and colleagues pooled data from 13 National Surgical Adjuvant Breast and Bowel Project clinical trials that had included more than 20,000 women.

In women from both ethnic groups who had estrogen-receptor (ER)-positive tumors, tamoxifen use was associated with a similar reduction in contralateral breast cancer. Tamoxifen use was also associated with a similar risk of thromboembolic events in both groups, and the risk of thromboembolic events was greater in women treated with both chemotherapy and tamoxifen compared with women treated with tamoxifen alone. Obesity and age were also risk factors for thromboembolic events. The authors conclude that tamoxifen is equally e
'"/>

Contact: Sarah Zielinski or Kate Travis
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
30-Nov-2004


Page: 1 2

Related medicine news :

1. Child care may affect entire communitys risks of infection
2. Short-term effects of spit tobacco suggest long-term health risks
3. Mayo Clinic study finds obese kidney donors face few increased risks
4. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
5. Study explores risks of obesity in children with kidney transplants
6. From town planning to intimate sex: Understanding the risks in our lives
7. More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
8. How to avoid the health risks of Hajj
9. Scientists study fish oil diet in bid to cut heart attack risks
10. Heart arrhythmias easily treated, yet few know risks
11. Maintaining stable weight, even in the obese, reduces heart risks

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tamoxifen risks similar African American and white women

(Date:8/1/2015)... ... 2015 , ... The condition where veins are enlarged and gnarled is known ... and discomfort. Those who spend a lot of time on their feet and standing ... doing what it can to create awareness and provide a cure in observance of ...
(Date:8/1/2015)... ... 01, 2015 , ... Brig and Lita Hart, icons of the network marketing ... Healthy Home mission with the HOPE Movement of EvolvHealth. In what has been a ... have agreed to join their missions of purpose together to change the course of ...
(Date:8/1/2015)... ... August 01, 2015 , ... Lume Wellness creators Alex, Robert, and ... download on the Apple AppStore. , The app is designed to track various ... as a tool to view personal health and use this information for positive behavior ...
(Date:8/1/2015)... ... ... March 19, 2015 Phil Valentine – the Executive Director of Connecticut Community for Addiction Recovery ... off Springer Mountain and heading north. Since that day, Phil has hiked over 1400 miles ... by friends and family. He visited CCAR and left an inspirational message to his ...
(Date:7/31/2015)... ... 31, 2015 , ... When the weather turned hot and warm-season turfgrasses, such ... sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for short. Incidentally, both ... this new type of sod, Super-Sod is giving away red Adirondack chairs with the ...
Breaking Medicine News(10 mins):Health News:Northeast Houston Vein Center Warns Men about Varicose Veins 2Health News:Northeast Houston Vein Center Warns Men about Varicose Veins 3Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2
(Date:7/31/2015)... July 31, 2015  Xencor, Inc. (NASDAQ: XNCR ... for the treatment of autoimmune diseases, asthma and allergic ... Yujiro S. Hata to its board of directors. ... and corporate development is a tremendous asset to our ... chief executive officer of Xencor. "Xencor faces a range ...
(Date:7/30/2015)... , July 30, 2015  ResMed ... has signed a definitive agreement to acquire ... non-invasive ventilation and sleep-disordered breathing medical devices ... innovation and market reputation in China, combined with ResMed,s global leadership in sleep ... in China suffering ...
(Date:7/30/2015)... July 30, 2015  Today we bring you a special edition of #MedicareMonday on ... you about some of our Medicare resources and continue highlighting the success of the ... Check out our latest infographics and videos here: http://onphr.ma/1INp9qQ ... ... ...
Breaking Medicine Technology:Xencor Appoints Yujiro S. Hata to Board of Directors 2Xencor Appoints Yujiro S. Hata to Board of Directors 3ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3
Cached News: