HOME >> MEDICINE >> NEWS
Tamoxifen's risks similar in African American and white women

African American and white women who are treated with tamoxifen for breast cancer appear to have the same risks of contralateral breast cancer and thromboembolic events, according to a new study in the December 1 issue of the Journal of the National Cancer Institute.

Between 2% and 15% of women who have been diagnosed with breast cancer will develop contralateral breast cancer--cancer in the opposite breast--depending on age and other factors. Tamoxifen has been shown to reduce the risk of contralateral breast cancer by 47% in women with early-stage primary breast cancer. However, the trials that demonstrated tamoxifen's benefits were done largely in populations of white women, and little data exists on the drug's effects on African American women. In addition, tamoxifen use is associated with an increased risk of thromboembolic events, such as stroke, and the African American population has more risk factors--such as cardiovascular disease and diabetes--for these events compared with the white population.

To determine if there is a difference in the occurrence of contralateral breast cancers and thromboembolic events between African American and white women with breast cancer who are treated with tamoxifen, Worta McCaskill-Stevens, M.D., of the National Cancer Institute, and colleagues pooled data from 13 National Surgical Adjuvant Breast and Bowel Project clinical trials that had included more than 20,000 women.

In women from both ethnic groups who had estrogen-receptor (ER)-positive tumors, tamoxifen use was associated with a similar reduction in contralateral breast cancer. Tamoxifen use was also associated with a similar risk of thromboembolic events in both groups, and the risk of thromboembolic events was greater in women treated with both chemotherapy and tamoxifen compared with women treated with tamoxifen alone. Obesity and age were also risk factors for thromboembolic events. The authors conclude that tamoxifen is equally e
'"/>

Contact: Sarah Zielinski or Kate Travis
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
30-Nov-2004


Page: 1 2

Related medicine news :

1. Child care may affect entire communitys risks of infection
2. Short-term effects of spit tobacco suggest long-term health risks
3. Mayo Clinic study finds obese kidney donors face few increased risks
4. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
5. Study explores risks of obesity in children with kidney transplants
6. From town planning to intimate sex: Understanding the risks in our lives
7. More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
8. How to avoid the health risks of Hajj
9. Scientists study fish oil diet in bid to cut heart attack risks
10. Heart arrhythmias easily treated, yet few know risks
11. Maintaining stable weight, even in the obese, reduces heart risks

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Tamoxifen risks similar African American and white women

(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... Routines… every ... – routines can help make things easier for parents, caregivers and children too. Here ... routines, transitions both big and small become more fluid. When a routine is implemented ...
(Date:9/1/2015)... ... September 01, 2015 , ... September is Baby Safety Month, and Lightning ... stickers to keep little ones' safety top of mind at all times. , Sponsored ... focus. According to the JPMA's Baby Safety Zone website, this year's theme is A ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... of professional hair salons. This highly anticipated partnership between Curly Hair Solutions™ and ... Styling Collection. Founder Jonathan Torch and the Curly Hair Solutions™ team could not ...
(Date:8/31/2015)... Orange, NJ (PRWEB) , ... September 01, 2015 ... ... the spine to eliminate chronic back pain – once required a long, arduous ... a shorter hospital stay, less pain, less blood loss and minimal muscle damage. ...
(Date:8/31/2015)... ... August 31, 2015 , ... Cosmetic ... the resources they need to have a successful cosmetic procedure; from publishing encyclopedic ... Cosmetic Town Journal is always ready to help. , It is clear that ...
Breaking Medicine News(10 mins):Health News:Back into the Swing of Things: How Family Routines Benefit Children 2Health News:Lightning Labels Can Help Make A Difference This Baby Safety Month 2Health News:Lightning Labels Can Help Make A Difference This Baby Safety Month 3Health News:Curly Hair Solutions™ Partners With Trade Secrets 2Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 2Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 3Health News:Minimally Invasive Spinal Fusions Squash Back Pain without Arduous Recovery 4Health News:Cosmetic Town: A One Stop Plastic Surgery Community 2
(Date:8/31/2015)... Aug. 31, 2015  DICOM Grid,  the #1 ... it was recognized as a semifinalist for a ... The awards are sponsored by Auntminnie.com, a ... in the medical imaging industry.  Since 1999, the ... to acknowledge the contributions of their peers. Nominations ...
(Date:8/31/2015)... JERUSALEM, Israel, Aug. 31, 2015  Chiasma, Inc. ... company developing octreotide capsules for the orphan condition ... quarter ended June 30, 2015 and provided a ... have been a transformative time for Chiasma, as ... recently announced that our first New Drug Application ...
(Date:8/31/2015)... Thousands of people will peacefully demonstrate their ... addiction epidemic at dozens of rallies across the country ... the United States has experienced skyrocketing ... and heroin, yet the President has never once spoken ... letter to President Obama , rally organizers compared his ...
Breaking Medicine Technology:DG Suite Nabs "Minnies" Nomination for "Best New Radiology Software" 2Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 2Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 3Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 4Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 5Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 6Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 7Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 8Chiasma Reports Second Quarter 2015 Financial Results and Recent Business Highlights 9Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2
Cached News: