HOME >> MEDICINE >> NEWS
Tamoxifen's risks similar in African American and white women

African American and white women who are treated with tamoxifen for breast cancer appear to have the same risks of contralateral breast cancer and thromboembolic events, according to a new study in the December 1 issue of the Journal of the National Cancer Institute.

Between 2% and 15% of women who have been diagnosed with breast cancer will develop contralateral breast cancer--cancer in the opposite breast--depending on age and other factors. Tamoxifen has been shown to reduce the risk of contralateral breast cancer by 47% in women with early-stage primary breast cancer. However, the trials that demonstrated tamoxifen's benefits were done largely in populations of white women, and little data exists on the drug's effects on African American women. In addition, tamoxifen use is associated with an increased risk of thromboembolic events, such as stroke, and the African American population has more risk factors--such as cardiovascular disease and diabetes--for these events compared with the white population.

To determine if there is a difference in the occurrence of contralateral breast cancers and thromboembolic events between African American and white women with breast cancer who are treated with tamoxifen, Worta McCaskill-Stevens, M.D., of the National Cancer Institute, and colleagues pooled data from 13 National Surgical Adjuvant Breast and Bowel Project clinical trials that had included more than 20,000 women.

In women from both ethnic groups who had estrogen-receptor (ER)-positive tumors, tamoxifen use was associated with a similar reduction in contralateral breast cancer. Tamoxifen use was also associated with a similar risk of thromboembolic events in both groups, and the risk of thromboembolic events was greater in women treated with both chemotherapy and tamoxifen compared with women treated with tamoxifen alone. Obesity and age were also risk factors for thromboembolic events. The authors conclude that tamoxifen is equally e
'"/>

Contact: Sarah Zielinski or Kate Travis
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
30-Nov-2004


Page: 1 2

Related medicine news :

1. Child care may affect entire communitys risks of infection
2. Short-term effects of spit tobacco suggest long-term health risks
3. Mayo Clinic study finds obese kidney donors face few increased risks
4. Researchers confirm Vioxx nearly doubled cardiovascular risks in cancer prevention study
5. Study explores risks of obesity in children with kidney transplants
6. From town planning to intimate sex: Understanding the risks in our lives
7. More studies on risks and benefits of COX-2 inhibitors published in Archives of Internal Medicine
8. How to avoid the health risks of Hajj
9. Scientists study fish oil diet in bid to cut heart attack risks
10. Heart arrhythmias easily treated, yet few know risks
11. Maintaining stable weight, even in the obese, reduces heart risks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
Breaking Medicine Technology:
Cached News: