Targeted Protein Toxin Effective Against Persistent Brain Tumors

Scientists at the National Institutes of Health have developed a new drug that can reduce the size of some persistent brain tumors without causing severe side effects. A report of the first clinical trial of this drug, called transferrin-CRM107, will appear in the December 1997 issue of Nature Medicine.

In the clinical trial(1), researchers led by Edward H. Oldfield, M.D., of the National Institute of Neurological Disorders and Stroke (NINDS), used a special pressurized pump to deliver transferrin-CRM107 directly to the tumor. This drug is a compound created by linking diphtheria toxin to a protein called transferrin that targets rapidly growing cells such as tumor cells. Nine of the 15 patients who were evaluated after this treatment had reductions in tumor size, and the tumor disappeared completely in two patients. While these results are promising, much more work remains before the drug may be ready for market approval.

In a related study in the same issue of Nature Medicine,(2) NINDS investigators led by Dr. Oldfield and colleagues from the National Cancer Institute and the National Human Genome Research Institute report on the first clinical trial of another new therapy, which uses virus-producing cells to deliver a herpes virus gene that increases tumor cells' sensitivity to the antiviral drug ganciclovir. The patients were later treated with ganciclovir to kill the tumor cells. However, this therapy worked only against very small tumors in four of the 15 patients who were evaluated.

The NINDS, one of the National Institutes of Health located in Bethesda, Maryland, supports a variety of research focused on improving the diagnosis and treatment of brain tumors. It is the nation's leading supporter of research on the brain and nervous system and a lead agency for the Congressionally designated Decade of the Brain.


Contact: Natalie Larsen or Stephanie Clipper
NIH/National Institute of Neurological Disorders and Stroke

Page: 1

Related medicine news :

1. Targeted antiviral prophylaxis of flu case contacts could successfully contain pandemic influenza
2. Smallpox outbreak response: Targeted vaccination may be almost as effective as mass vaccination
3. Targeted smallpox vaccinations could be effective intervention against deliberate attack
4. Targeted toxins may revolutionize pain therapy
5. Breakthrough New Therapy Uses Antibody-Targeted Chemotherapy To Fight Leukemia
6. Fred Hutchinson Cancer Research Center And Targeted Genetics Corp. Publish Data On Adoptive Immunotherapy For HIV
7. Promising New Drug Uses Antibody Targeted Chemotherapy To Fight Leukemia
8. Protein that helps skin cancer spread identified by Stanford researchers
9. Proteins found in urine of pregnant women could help diagnose preeclampsia
10. Protein that promotes survival of stem cells might be key to poor leukemia prognosis
11. Protein key could aid search for cancer drugs

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: