M. Elizabeth Halloran, M.D., D.Sc., and Ira M. Longini, Jr., Ph.D., professors of biostatistics at Emory University's Rollins School of Public Health, along with colleagues Azhar Nizam and Yang Yang, constructed a model that simulated the spread of smallpox deliberately introduced by infected individuals moving through a community. The model is based on the investigators' previous experience with modeling flu epidemics. It assumes that people interact primarily within known contact groups, including their own household, schools or daycare centers, their neighborhood and their community. The model differs from other recent models of smallpox epidemics that assume random mixing of individuals within a large, homogeneous population, with the conclusion that mass vaccination is the only way to sufficiently control an outbreak.
The Emory model simulated a range of scenarios for smallpox epidemics, based on different probabilities of how smallpox might spread, whether or not there was residual immunity from prior vaccinations, at what stage individuals might stay home during different stages of their disease, and the effectiveness of smallpox vaccines in different age
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Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
14-Nov-2002