Targeted smallpox vaccinations could be effective intervention against deliberate attack

or after an epidemic begins, with 80% coverage within 10 days.

In the targeted vaccination scenario, people in close contact with either 80% or 100% of identified cases were vaccinated. Targeted vaccination included all household members, all day care and play group contacts, 80-100% of children in the same school, and 1.5% of neighborhood contacts. Vaccinations began either with the first known case or after the 15th or 25th case to account for possible delays in vaccination. In simulations of both mass and targeted vaccinations, a rapid response to identified smallpox cases made a significant difference in the ability to prevent or contain an epidemic.

"Our study demonstrates the importance of modeling the details of likely contact patterns when developing strategies to prevent or contain a deliberately planned smallpox epidemic," says Dr. Halloran. "We found, as have other investigators, that a rapidly implemented mass vaccination strategy following a smallpox outbreak would be more effective than targeted vaccination if there is no pre-existing immunity.

However, our model found a much smaller difference in effectiveness between the two strategies than did previous models that assumed homogeneous mixing within a large population. And, taking into account possible pre-existing immunity, the potential for increasing that pre-existing immunity, and the desirability of decreasing harmful vaccine reactions, we believe it is important to continue a serious exploration of the benefits of targeted vaccination. We will continue to refine our simulation to better reflect the variations and conditions within a large U.S. population. It also will be very important to include new information, as it becomes available, about the immune protection offered by prior immunizations."

"The daily contacts that people make within their communities could have a significant impact on the speed of smallpox spread and the reach of an epidemic," Dr

Contact: Holly Korschun
Emory University Health Sciences Center

Page: 1 2 3 4

Related medicine news :

1. Targeted antiviral prophylaxis of flu case contacts could successfully contain pandemic influenza
2. Smallpox outbreak response: Targeted vaccination may be almost as effective as mass vaccination
3. Targeted toxins may revolutionize pain therapy
4. Breakthrough New Therapy Uses Antibody-Targeted Chemotherapy To Fight Leukemia
5. Fred Hutchinson Cancer Research Center And Targeted Genetics Corp. Publish Data On Adoptive Immunotherapy For HIV
6. Promising New Drug Uses Antibody Targeted Chemotherapy To Fight Leukemia
7. Targeted Protein Toxin Effective Against Persistent Brain Tumors
8. Stanford scientists help bring study of smallpox virus into molecular age
9. NIAID forms network to tackle potentially fatal reaction to smallpox vaccine
10. Cardiac complications from smallpox vaccination higher than expected among military personnel
11. HIV-positive U.S. military personnel accidentally vaccinated against smallpox

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: