Targeting cell fusion as possible way to repair organs, deliver cancer vaccines

ROCHESTER, Minn. -- Mayo Clinic cancer researchers have developed a way to biologically fuse living cells through the use of a genetically engineered cell membrane. This process, which Mayo researchers call "biofusion," could speed development of new tumor treatments and cancer vaccines.

The Mayo Clinic cancer researchers' study on biofusion appears in the current issue of Nature Biotechnology (http://www.nature.com/nbt/). The researchers report their new process kills cancer tumor cells, based on their successful treatment of mice into which human cancers were implanted.

Significance of the Mayo Clinic Cancer Research

"Our biofusion research represents a promising new technological platform for enlisting natural properties of fused cells to kill cancers, stimulate immune responses or repair damaged tissues," says Stephen Russell, M.D., Ph.D. Dr. Russell directs Mayo Clinic's Molecular Medicine Program and leads the Mayo Clinic Cancer Center's Gene and Virus Therapy Program.

The key to biological cell fusion is that two cells come into contact and the fusion proteins on the surface of one cell recognize a receptor on the other cell. This act of recognition triggers fusion of their respective outer lipid membranes. "It's like two bubbles merging into one bigger bubble," explains Dr. Russell.

With cancer, the fusion rules change, says Dr. Russell. When cancer cells fuse with each other the "big bubble" formed may grow dramatically -- containing up to 1,000 cancer cells -- and it is nonviable. The cancer cells therefore die.

This fact that fused cancer cells kill each other has been known for some years. The missing element has been a way to direct fusion partners to exploit this tendency and use it as a basis for anticancer treatment.

The ability to target fusion partners is important. If the wrong cells fuse, then healthy cells -- instead

Contact: Mary Lawson
Mayo Clinic

Page: 1 2 3

Related medicine news :

1. Targeting mutant B-Raf protein reduces melanoma development
2. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
3. Targeting bone metastasis and hypercalcemia
4. Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
5. Diffusion-weighted MRI can diagnose mad cow-related disease in humans before symptoms show
6. Article highlights confusion about Homeland Security safety symbols
7. Information fusion research simulates disasters to manage emergency response
8. NHLBI stops sickle cell anemia transfusion study
9. Ongoing transfusions needed to avoid strokes in children with sickle cell disease
10. Blood transfusion poses CJD risk
11. Mayo researchers observe genetic fusion of human, animal cells -may help explain origin of AIDS

Post Your Comments:

(Date:9/3/2020)... TAMPA, Fla. (PRWEB) , ... September 03, 2020 ... ... today announced it is sponsoring the American Foundation for Suicide Prevention’s (AFSP) annual ... of a million people across hundreds of U.S. cities to raise awareness of ...
(Date:9/3/2020)... ... September 03, 2020 , ... MemoryCare.com, a comprehensive resource for ... Care Facilities in Louisville, KY. The guide identifies 17 memory care communities based ... the Alzheimer’s Association , 5.6 million people age 65 and older are ...
(Date:9/1/2020)... ... September 01, 2020 , ... Board ... in Glendale. While the office will be the first to bear her name, ... buttock augmentation (Brazilian butt lift), as well as rhinoplasty, facial rejuvenation, and many ...
(Date:9/1/2020)... ... September 01, 2020 , ... As fall and winter swiftly approach ... Health Institute has taken this time to expand and grow into a full-fledged ... the Cohn Health Institute will be relaunching its brand new website, expanding its services ...
(Date:8/31/2020)... ... August 31, 2020 , ... The Lymphoma ... funding innovative lymphoma research and serving the lymphoma community through a comprehensive series ... Anniversary of Blood Cancer Awareness Month (BCAM) and its international Light it ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... 27, 2020 , ... Bleep LLC, maker of the DreamPort mask-less CPAP solution, ... company’s new spokesperson. , “In my line of work, a good night of sleep ... DreamPort it was a Bleeping no brainer for me,” said Jensen. “From the moment ...
(Date:8/26/2020)... ... August 26, 2020 , ... ScripHessco ... Sports Injuries. The infographic breaks down ways that chiropractors can help heal sports ... According to ScripHessco “Athletes have an unusual amount of pressure and stress on ...
(Date:8/26/2020)... ... August 26, 2020 , ... Clinical ... definitive agreement to acquire ProCE, a nationally recognized provider of continuing education ... , CEA represents a growing alliance of CME/CE and service organizations that ...
Breaking Medicine Technology:
Cached News: