HOME >> MEDICINE >> NEWS
Targeting cell fusion as possible way to repair organs, deliver cancer vaccines

of cancer -- can be killed. "Our biofusion research brings a new level of control to the system so the right fusion matches are made to serve therapeutic ends," says Dr. Russell. "It offers a biotechnology platform that provides a way to choose and direct the agents of fusion by getting tumor cells to fuse with dendritic cells -- one cell type in the immune system. The result is biofusion that prompts the immune system to attack the tumor.

"This is important because the exploitation of cell fusion, whether for killing cancer cells, repairing damaged tissues or stimulating the immune system, depends on making sure that it is accurately targeted," he says.

Potential Applications

The ability to fuse tumor cells to treat cancers is one application the Mayo Clinic cancer research team envisions for their biofusion platform.

Another possible application involves cancer vaccines that prevent cancer from progressing or developing. Current vaccine approaches involve taking dendritic cells from cancer patients, feeding the dendritic cells tumor antigens, and then reintroducing the dendritic cells into the patient's body and relying on the body's natural process of "instruction" to help the body create cells that attack cancer. In this natural system, dendritic cells present antigens to other immune cells in a way that effectively "teaches" them what they are to attack.

Dr. Russell believes the biofusion technology would be a better way of "feeding" the dendritic cells the information they need to "learn" what they are to attack.

"Biofusion would involve putting genes in the dendritic cells inside the body that will cause them to fuse directly into tumors at multiple sites in the patient," he says. He notes that Mayo Clinic cancer research colleague Richard Vile, Ph.D., last year successfully fused tumor and dendritic cells to create a hybrid of the two -- but it was not targeted. "So this is not blue-sky stuf
'"/>

Contact: Mary Lawson
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
17-Feb-2004


Page: 1 2 3

Related medicine news :

1. Targeting mutant B-Raf protein reduces melanoma development
2. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
3. Targeting bone metastasis and hypercalcemia
4. Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
5. Diffusion-weighted MRI can diagnose mad cow-related disease in humans before symptoms show
6. Article highlights confusion about Homeland Security safety symbols
7. Information fusion research simulates disasters to manage emergency response
8. NHLBI stops sickle cell anemia transfusion study
9. Ongoing transfusions needed to avoid strokes in children with sickle cell disease
10. Blood transfusion poses CJD risk
11. Mayo researchers observe genetic fusion of human, animal cells -may help explain origin of AIDS

Post Your Comments:
(Date:4/17/2014)... of chronic inflammation in non-cancerous prostate tissue may have ... than those with no inflammation, according to results of ... Hopkins Kimmel Cancer Center. , The link between persistent ... so-called high-grade prostate cancer those with a Gleason ... of the most aggressive and rapidly growing prostate cancers. ...
(Date:4/17/2014)... to a study published today in PLOS Pathogens ... where malaria is common can mount an immune response ... to avoid repeated bouts of high fever and illness ... their bloodstream. The findings may help researchers develop future ... the malaria parasite. , Each year, approximately 200 million ...
(Date:4/17/2014)... MANHASSET, NY In a review published in the ... MD, president of The Feinstein Institute for Medical Research, ... the medical community,s approach to treating sepsis, ... 200,000 Americans. , Sepsis occurs when molecules released into ... inflammation throughout the body. Inflammation is necessary for maintaining ...
(Date:4/17/2014)... Doctors who treat patients with a severe and ... an agonizing treatment decision. , The drug sirolimus ... relieve shortness of breath. But some patients eventually ... potentially fatal complications following transplantation. , "It,s a ... director of Loyola University Medical Center,s LAM Clinic ...
(Date:4/17/2014)... By discovering a new mechanism that allows blood to ... UC Irvine and the Salk Institute have opened the ... stroke-induced brain damage. , A complex and devastating neurological ... primary reason for disability in the U.S. The blood-brain ... blood-borne material into the brain, causing the permanent deficits ...
Breaking Medicine News(10 mins):Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:Study IDs new cause of brain bleeding immediately after stroke 2
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
(Date:1/15/2014)... Jan. 15, 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... offering. (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ... used on patients in order to treat dental impairments, ...
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today announced it ... adults suffering from the severe cold weather that has gripped ... to helping those in need; so to support these emergency ... up to $250,000, which could mean up to $500,000 in ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3
Cached News: