HOME >> MEDICINE >> NEWS
Targeting cell fusion as possible way to repair organs, deliver cancer vaccines

of cancer -- can be killed. "Our biofusion research brings a new level of control to the system so the right fusion matches are made to serve therapeutic ends," says Dr. Russell. "It offers a biotechnology platform that provides a way to choose and direct the agents of fusion by getting tumor cells to fuse with dendritic cells -- one cell type in the immune system. The result is biofusion that prompts the immune system to attack the tumor.

"This is important because the exploitation of cell fusion, whether for killing cancer cells, repairing damaged tissues or stimulating the immune system, depends on making sure that it is accurately targeted," he says.

Potential Applications

The ability to fuse tumor cells to treat cancers is one application the Mayo Clinic cancer research team envisions for their biofusion platform.

Another possible application involves cancer vaccines that prevent cancer from progressing or developing. Current vaccine approaches involve taking dendritic cells from cancer patients, feeding the dendritic cells tumor antigens, and then reintroducing the dendritic cells into the patient's body and relying on the body's natural process of "instruction" to help the body create cells that attack cancer. In this natural system, dendritic cells present antigens to other immune cells in a way that effectively "teaches" them what they are to attack.

Dr. Russell believes the biofusion technology would be a better way of "feeding" the dendritic cells the information they need to "learn" what they are to attack.

"Biofusion would involve putting genes in the dendritic cells inside the body that will cause them to fuse directly into tumors at multiple sites in the patient," he says. He notes that Mayo Clinic cancer research colleague Richard Vile, Ph.D., last year successfully fused tumor and dendritic cells to create a hybrid of the two -- but it was not targeted. "So this is not blue-sky stuf
'"/>

Contact: Mary Lawson
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
17-Feb-2004


Page: 1 2 3

Related medicine news :

1. Targeting mutant B-Raf protein reduces melanoma development
2. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
3. Targeting bone metastasis and hypercalcemia
4. Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
5. Diffusion-weighted MRI can diagnose mad cow-related disease in humans before symptoms show
6. Article highlights confusion about Homeland Security safety symbols
7. Information fusion research simulates disasters to manage emergency response
8. NHLBI stops sickle cell anemia transfusion study
9. Ongoing transfusions needed to avoid strokes in children with sickle cell disease
10. Blood transfusion poses CJD risk
11. Mayo researchers observe genetic fusion of human, animal cells -may help explain origin of AIDS

Post Your Comments:
(Date:3/27/2015)... The Monogamy Method - a new ... Jason Rogers has just been released to the public ... surrounding the course's launch has caught the attention of ... review of the new program. , "Many women report ... suddenly start pulling away or expressing interest in other ...
(Date:3/27/2015)... March 27, 2015 Wellness for Cancer–the ... business criteria for the spa and wellness industry–has certified ... who have experienced or are living with cancer. ... Wellness 365® Network, will be identified with a special ... a provider of safe, therapeutic services for cancer patients. ...
(Date:3/27/2015)... Deer, Alberta (PRWEB) March 27, 2015 In ... until then, prevented her from working, Monica K. arrived at ... in the mending department quiet, defensive and scared. The owners ... Placement & Support Services (EPSS) to offer jobs to ... does take patience and a willingness to begin with the ...
(Date:3/27/2015)... Tampa, FL (PRWEB) March 27, 2015 Florida ... Bay Storm as the team’s exclusive health care provider for ... care provider, Florida Hospital provides medical care and an athletic ... Bay Storm will kick off its season against the Cleveland ... , “This partnership is extremely important to us as ...
(Date:3/27/2015)... York (PRWEB) March 27, 2015 The ... ) that allege the statin medication increases the risk ... granted Pfizer Inc.’s Motion to Dismiss four individual cases ... a Case Management Order issued in the U.S. District ... Court determined that the dismissals were warranted because the ...
Breaking Medicine News(10 mins):Health News:The Monogamy Method - Review Of Samantha Sanderson & Jason Rogers' Relationship Program Released 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 2Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 3Health News:Hands On HealthCare Massage Therapy & Wellness Day Spa Certified as “Cancer Aware” by Wellness for Cancer and Recognized on Spafinder.com 4Health News:Red Deer Uniforms Shop Celebrates 3rd Year Sewing Hope for the Challenged 2Health News:Red Deer Uniforms Shop Celebrates 3rd Year Sewing Hope for the Challenged 3Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 2Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 3
(Date:3/27/2015)... The International Myeloma Foundation (IMF) – improving ... toward prevention and a cure – today commended Representative ... resolution (H. Res. 174) that supports the designation of ... Awareness Month." Currently there are more than ... 110,000 new cases are diagnosed yearly, according to the ...
(Date:3/27/2015)... 27, 2015 RnRMarketResearch.com adds ... market research report of 52 pages with latest ... intelligence library. The report "Visceral Pain - Pipeline ... therapeutic development for Visceral Pain, complete with comparative ... target, mechanism of action (MoA), route of administration ...
(Date:3/26/2015)... , March 26, 2015  The Burzynski ... a study independently conducted by the Department of ... Japan have been published. The ... 5-fluorouracil hepatic arterial infusion as post-operative adjuvant therapy ... metastasis of the liver. A ...
Breaking Medicine Technology:The International Myeloma Foundation (IMF) Secures the Introduction of a Federal Resolution Recognizing March 2015 as "National Multiple Myeloma Awareness Month" 2Visceral Pain Pipeline Review H1 2015 Market Research Report 2Visceral Pain Pipeline Review H1 2015 Market Research Report 3Visceral Pain Pipeline Review H1 2015 Market Research Report 4
Cached News: