HOME >> MEDICINE >> NEWS
Targeting cell fusion as possible way to repair organs, deliver cancer vaccines

of cancer -- can be killed. "Our biofusion research brings a new level of control to the system so the right fusion matches are made to serve therapeutic ends," says Dr. Russell. "It offers a biotechnology platform that provides a way to choose and direct the agents of fusion by getting tumor cells to fuse with dendritic cells -- one cell type in the immune system. The result is biofusion that prompts the immune system to attack the tumor.

"This is important because the exploitation of cell fusion, whether for killing cancer cells, repairing damaged tissues or stimulating the immune system, depends on making sure that it is accurately targeted," he says.

Potential Applications

The ability to fuse tumor cells to treat cancers is one application the Mayo Clinic cancer research team envisions for their biofusion platform.

Another possible application involves cancer vaccines that prevent cancer from progressing or developing. Current vaccine approaches involve taking dendritic cells from cancer patients, feeding the dendritic cells tumor antigens, and then reintroducing the dendritic cells into the patient's body and relying on the body's natural process of "instruction" to help the body create cells that attack cancer. In this natural system, dendritic cells present antigens to other immune cells in a way that effectively "teaches" them what they are to attack.

Dr. Russell believes the biofusion technology would be a better way of "feeding" the dendritic cells the information they need to "learn" what they are to attack.

"Biofusion would involve putting genes in the dendritic cells inside the body that will cause them to fuse directly into tumors at multiple sites in the patient," he says. He notes that Mayo Clinic cancer research colleague Richard Vile, Ph.D., last year successfully fused tumor and dendritic cells to create a hybrid of the two -- but it was not targeted. "So this is not blue-sky stuf
'"/>

Contact: Mary Lawson
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
17-Feb-2004


Page: 1 2 3

Related medicine news :

1. Targeting mutant B-Raf protein reduces melanoma development
2. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
3. Targeting bone metastasis and hypercalcemia
4. Effective Obesity Treatment Likely To Require Targeting Of Multiple Weight Control Systems
5. Diffusion-weighted MRI can diagnose mad cow-related disease in humans before symptoms show
6. Article highlights confusion about Homeland Security safety symbols
7. Information fusion research simulates disasters to manage emergency response
8. NHLBI stops sickle cell anemia transfusion study
9. Ongoing transfusions needed to avoid strokes in children with sickle cell disease
10. Blood transfusion poses CJD risk
11. Mayo researchers observe genetic fusion of human, animal cells -may help explain origin of AIDS

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/20/2017)... ... July 20, 2017 , ... Vixiar Medical, ... devices and systems for monitoring cardiopulmonary diseases, announced today that it has raised ... complete regulatory submissions and fund final engineering and initial production of the Company’s ...
(Date:7/20/2017)... ... 20, 2017 , ... There’s a lot of confusing lingo out there surrounding ... same thing. But it’s crucial to understand both the differences and similarities between these ... Liu, MD, PhD, founder and president of Atlantic Spine Center . , ...
(Date:7/20/2017)... ... July 19, 2017 , ... A local summer theatre camp ... raised to support fine arts programs in Chester County’s Elementary Schools. In late ... Loyd Auditorium. , More than 850 people attended the two performances, an ...
(Date:7/20/2017)... ... July 19, 2017 , ... Adolfson & Peterson ... manager, Josh Christensen. As a leader in healthcare construction, AP has successfully built ... resume in the Midwest with Josh now on board. , Josh brings ...
(Date:7/18/2017)... CA (PRWEB) , ... July 18, 2017 , ... CannaKids, ... scientist extracted cannabis oils, announced today that at the WORLDZ Summit, taking place in ... be speaking on the therapeutic benefits of medical cannabis for both pediatric and adult ...
Breaking Medicine News(10 mins):
(Date:7/6/2017)... the nutrition division of Diplomat Specialty Infusion Group, is celebrating a decade ... To celebrate its anniversary, ThriveRx recently launched a redesigned website at ... improved organization to create the best user experience for consumers and health ... Diplomat ... "We,ve made several great strides throughout the past ...
(Date:7/5/2017)... 2017   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade cell and tissue hypothermic ... today announced that it has reached an agreement with ... shareholder, to modify its existing credit facility effective June ... WAVI agreed to exchange its existing $4.25 million credit ...
(Date:6/30/2017)... , June 29, 2017  Axium Pharmaceuticals Inc. is a pharmaceutical ... novel formulations and alternative dosage forms of existing biologically active ... ... on our waterless self-nano emulsifying formula, which is designed to ... We believe the spray will provide fast onset of action ...
Breaking Medicine Technology:
Cached News: