Testosterone skin patch improves sexual functioning in surgically menopa...( analysis was gathered for 65 study part...),Health

analysis was gathered for 65 study participants. The women reported increased sexual activity and pleasure in all three treatment periods, including placebo, but significantly greater improvement was seen at the 300 microgram dose level compared to placebo. The women also reported improved overall psychological well being with treatment. Adverse side effects of the type often associated with excess testosterone levels were not reported at significant levels. Most importantly the levels of HDL-cholesterol, the so-called "good cholesterol," were not lowered by transdermal testosterone treatment.

Testosterone levels remained low during placebo periods but rose to mid-normal and high-normal levels when women received the 150- and 300-microgram doses, respectively. The testosterone treatments had no effect on the participants' estrogen levels.

The researchers noted that even women receiving placebo doses reported improved sexual functioning compared with their experiences before starting the study. They note that a number of factors could explain this response - including the women's strong motivation to improve their sex lives, improved communication with sexual partners, the presence of the patches as a visible reminder of the treatment's goal, and continuation of patterns of greater sexual activity that began when the women were receiving active doses. However, the higher testosterone dose improved sexual functioning and psychological well-being substantially more than did placebo treatment.

This study was part of a Phase II clinical development program for the testosterone patch conducted by Procter and Gamble Pharmaceuticals and Watson Laboratories. Enrollment is currently under way for a larger study of the patch at sites in the US, Europe and Australia. Women aged 20 to 70 who are experiencing impaired sexual functioning after surgical menopause and who would like information about
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Contact: Susan McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
6-Sep-2000

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