The Lancet Neurology November pre...( mise of the ADAPT and disputes the con...)

The Lancet Neurology November press release

mise of the ADAPT, and disputes the concerns raised by the PCHAG letter.

Secretases as targets for the treatment of Alzheimer's disease: the prospects

Abnormal accumulation of amyloid-beta peptide into extracellular plaques is thought to be responsible for the neurodegeneration and dementia seen in Alzheimer's disease. Amyloid-beta peptide is produced from the much larger amyloid precursor protein (APP) by the action of enzymes called "secretases". These enzymes are possible therapeutic targets to prevent or slow the onset of Alzheimer's disease. A review (http://neurology.thelancet.com/journal/vol1/iss7/abs/lneu.1.7.review_and_opinion.22749.1) by Ilse Dewachter and Fred Van Leuven (KU Leuven, Leuven, Belgium) discusses the rationale behind this approach.

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Contact: Richard Lane
richard.lane@lancet.com
44-207-424-4949
Lancet
16-Oct-2002

Page: 1 2
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The Lancet Neurology November pre...( mise of the ADAPT and disputes the con...),Health