The effect of osteoporosis drugs on osteoarthritis of the knee

Osteoarthritis (OA) of the knee, a chronic inflammatory disease marked by cartilage degradation and bone abnormalities, is a leading cause of disability among elderly people in the United States. Although drugs commonly prescribed for the disease work to ease joint pain and stiffness, they do not provide a cure. Consequently, a substantial number of people affected ultimately undergo total knee replacement surgery.

There is reason to believe that some drugs used to treat osteoporosis may also have a beneficial effect on arthritis. Recently, a nationwide team of researchers led by Laura D. Carbone, M.D., M.S. at the University of Tennessee Health Sciences Center evaluated the effects of such bone-strengthening drugs on knee OA in the Health, Aging, and Body Composition (ABC) Study, supported by grants from the National Institute on Aging. Their findings, published in the November 2004 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/journal/arthritis), indicate the promise of alendronate (better known as Fosamax) and estrogen to protect the knee joint from the changes of OA.

The study focused on 818 elderly women 75 was the average age enrolled in the ABC Study, a long-term study of the factors that contribute to disability in the elderly being conducted at the University of Tennessee and the University of Pittsburgh. 411 of the subjects were white; the remaining 407 were African-American. Of the total group, 214 women were taking bone antiresorptive agents, primarily estrogen or alendronate. The mean duration of drug use was 13.8 years for estrogen and 1.8 years for alendronate. There were no significant differences between the drug users and the non-users with respect to age, current smoking status, or anti-inflammatory drug therapy, although users of these drugs were more likely to be white, to be thinner, and to take calcium supplements.

Contact: David Greenberg
John Wiley & Sons, Inc.

Page: 1 2 3

Related medicine news :

1. Strategy effective against drug resistant tuberculosis
2. Study shows patch therapy may be as effective as oral medications
3. Chronic pain treatments more effective when taken together, new study shows
4. Geodon effective in psychiatric emergencies; Sharply reduces time in restraints
5. Brain activity prior to treatment flags vulnerability to antidepressant side effects
6. Improving access to healthy food has little effect on diet
7. Storage time and temperature effects nutrients in spinach
8. Costs of antidepressants could have funded effective alternatives
9. New ways to design safer & more effective topical (transdermal) drug delivery announced in the PNAS
10. Government wasting your taxpayer money on ineffective drug cure
11. Neurobehavioral function during coma, stroke rehabilitation effective for elderly

Post Your Comments:

(Date:3/30/2020)... ... March 30, 2020 , ... Frontline Public Safety Solutions is ... an effort to keep frontline officers and the public safe in the face ... while minimizing direct contact. They are also freeing up 911 lines for genuine ...
(Date:3/28/2020)... ... March 27, 2020 , ... The construction industry is taking ... the coronavirus. Operating under the designation as an essential business as modified today ... protection projects in the downstate New York region. , While certain projects have ...
(Date:3/28/2020)... CINCINNATI (PRWEB) , ... March 28, 2020 , ... ... revenue cycle management services, integrated practice management, and patient engagement solutions has expanded ... coronavirus outbreak. , In this time of crisis, telemedicine has a big ...
(Date:3/27/2020)... ... 27, 2020 , ... On March 27th, 2020, Talos Health Solutions , ... their families and caregivers living in the US. This free online conference will be ... 2020, and will focus on asthma symptoms, the different kinds of asthma, treatment options, ...
(Date:3/22/2020)... Va. (PRWEB) , ... March 21, 2020 , ... ... Building Institute (MBI) and the Modular Home Builders Association (MHBA), have been working ... efforts. , MHBA has been advocating for greater use of modular construction ...
Breaking Medicine News(10 mins):
(Date:3/28/2020)... , ... March 27, 2020 , ... ... Isagenix International has named Gary Gallant as its permanent CIO. In this ... company’s technology vision, ensuring Isagenix can provide a smooth shopping experience for customers ...
(Date:3/27/2020)... ... March 27, 2020 , ... A new survey conducted ... holistic portfolios, revealed that college-bound young adults are reconsidering their higher education options ... barriers to high school senior’s path to college and possibly dashing those hopes ...
(Date:3/22/2020)... ... , ... As the spread of Coronavirus (COVID-19) continues to ... and Surgery, and the Temple Lung Center have taken proactive steps to protect ... triage/care coordination services. Temple is now enrolling patients, faculty, staff, frontline workers and ...
Breaking Medicine Technology:
Cached News: