HOME >> MEDICINE >> NEWS
Therapy for mice with prion disease could offer benefit to human beings with CJD

Authors of a fast-track research letter in this week's issue of THE LANCET describe a therapeutic treatment which increased the survival time for mice with prion disease. These results could represent a new approach to treating CJD in human beings.

The lack of an immune response to prions--the infectious proteins that cause scrapie, bovine spongiform encephalopathy (BSE), and Creutzfeldt-Jakob disease (CJD)--might be related to the fact that these agents do not contain nucleic acids (genetic material).

Hans Kretzschmar from Ludwig-Maximilians University and colleagues from the Technical University Munich, Germany, and Coley Pharmaceuticals, aimed to use genetic material (a specific type of nucleotide arrangement called CpG oligodeoxynucleotides) as a form of disease treatment after prion infection in mice. CpG oligodeoxynucleotides have previously been shown to stimulate the immune response.

The investigators inoculated 24 healthy mice with brain extracts from mice infected with scrapie prions, and then injected CpG oligodeoxynucleotides. This procedure resulted in 38% longer survival times than a control group that were injected with saline solution; longer survival times occurred when CpG oligodeoxynucleotides were given repeatedly over a three-week period.

Hans Kretzschmar comments: "The most likely explanation is the stimulation of TLR9-expressing cells of the innate immune system such as macrophages, monocytes, and dendritic cells. CpG oligodeoxynucleotides have not been shown to have adverse effects to human health and could therefore be considered as a therapeutic choice after prion infection."

In an accompanying Commentary (p 184), George Carlson from the McLaughlin Research Institute, USA, states that the approach of Kretzschmar and colleagues is reasonable, and concludes: "Development of improved diagnostics and postexposure prophylaxis are urgently needed given the unknown prevalence of subclinical prion infecti
'"/>

Contact: Richard Lane
richard.lane@lancet.com
44-20-7424-4949
Lancet
18-Jul-2002


Page: 1 2

Related medicine news :

1. UT Southwestern Moncrief Cancer Center is first in Texas to treat patients with TomoTherapy
2. Therapy, medication combination superior for children with obsessive-compulsive disorder
3. Oncology Nursing Society honors Fox Chase Cancer Center nurse with Radiation Therapy Nursing Award
4. Vagus Nerve Stimulation Therapy (TM) more effective in epilepsy patients when used earlier
5. Therapy to help women reduce their concerns about gaining weight found to be effective in helping them to stop smoking
6. Results of NUVANCE (IL-4 receptor) in Phase I/II study in asthma patients featured at AAAAI Late-Breaker Abstract and Asthma Therapy Sessions
7. UCSF Study Shows That An Herbal Therapy Reduces PSA Levels By Half In Men With Advanced Prostate Cancer
8. Sniffing Out The Promise Of Anti-Angiogenesis Therapy
9. Breakthrough New Therapy Uses Antibody-Targeted Chemotherapy To Fight Leukemia
10. Jefferson Researchers Report First Evidence Of Radiation Therapy Preventing Prostate Cancer Patients From Dying
11. Combination Therapy Improves Chances Of Surviving Esophageal Cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/18/2019)... ... , ... HR Maximizer Inc ( https://hrmaximizer.com ) announced today ... Healthcare HR Association (HHHRA - https://hhhra.org ). In addition to having ... PageUp, CRC, Alliance Work Partners and Kognito. , Houston Healthcare HR Association, The ...
(Date:6/16/2019)... , ... June 15, 2019 , ... Convoy of Hope ... has been committed to helping those in need around the world. To date, Convoy ... than 125 countries. Convoy’s work would not be possible without the dedication and generosity ...
(Date:6/13/2019)... DETROIT (PRWEB) , ... June 13, 2019 , ... Endometriosis is a painful, inflammatory disease ... , Painful periods , Heavy bleeding , ... Constipation , Women’s Excellence uses the latest and newest treatment protocols in ...
(Date:6/13/2019)... ... June 13, 2019 , ... Pure Ratios, the ... cannabis delivery company, Driven Deliveries, Inc., the only publicly traded cannabis delivery service ... the population of California with overnight cannabis delivery to major thriving markets such ...
(Date:6/13/2019)... (PRWEB) , ... June 13, 2019 , ... Clinical ... experience, is pleased to announce that Jonathan Andrus , chief business officer at ... by the Duke-Margolis Center for Health Policy on July 1, 2019, in ...
Breaking Medicine News(10 mins):
(Date:6/14/2019)... (PRWEB) , ... June 14, 2019 , ... ... National Cyclotron and PET Centre, Chulabhorn Hospital announced today a research collaboration to ... of aging Thai individuals. The first subjects have been recruited and imaged. LMI ...
(Date:6/13/2019)... (PRWEB) , ... June 13, 2019 , ... ... as a Prime awardee of the Network of Quality Improvement and Innovation Contractor. ... five years. As a Prime NQIIC awardee partnering with other Quality Improvement ...
(Date:6/13/2019)... ... June 13, 2019 , ... ... has announced the new Smart Scheduling product, part of the HCHB Intelligence Suite, ... Scheduling product uses complex algorithms to create highly efficient routing, mapping and scheduling ...
Breaking Medicine Technology:
Cached News: