Three-month antibiotic treatment reduces risk of future heart attack

DALLAS, March 12 An antibiotic prolonged life and reduced risk of future heart attacks in people hospitalized for heart attack or unstable angina, according to a report in todays rapid access issue of Circulation: Journal of the American Heart Association.

The antibiotic clarithromycin significantly lowered risk of death or serious cardiovascular events compared to those given a placebo. Clarithromycin is typically prescribed for respiratory infections.

Patients with acute heart attacks or severe angina seem to benefit from treatment with a macrolide antibiotic, says lead author Juha Sinisalo, M.D., of Helsinki University Central Hospital in Helsinki, Finland. The most likely mechanism of action is clarithromycins antibacterial effect.

Infections are one cause of inflammation, and inflammation plays an important role in the development of coronary heart disease. Increasing evidence from animal and human studies indicates that several infections such as Chlamydia pneumoniae are associated with coronary heart disease.

Although the apparent advantage of clarithromycin likely stems from its antibacterial power, the drug may do double duty in coronary heart disease patients. Clarithromycin also has an anti-inflammatory action that is independent of its effect on bacteria, he says.

There are only two ways to prove the connection between infections and coronary artery disease: vaccinations and antibiotic therapy, says Sinisalo. Vaccinations to prevent heart disease are not available. Therefore, we conducted this study to find out if suppressing infections would decrease the rate of new heart attacks.

Researchers have published results from only a few studies that have tested antibiotics for patients with a high risk of heart attack. Trials in patients with stable heart disease have yielded differing results. In a previous randomized study, a macrolide antibiotic was used for one month to treat people with acute coronary problems.

Contact: Carole Bullock
American Heart Association

Page: 1 2 3

Related medicine news :

1. Invasive pneumonia and antibiotic resistance decreased after childhood vaccine introduced
2. Study examines three-day antibiotic regimens for treating bladder infection in women
3. Immediate access to antibiotics stems spread of sexually transmitted diseases
4. Over prescribing causing high rates of antibiotic resistance in south and east Europe
5. Middle ear infections: Prescribe antibiotics or not?
6. Study explores antibiotic misuse
7. OTC treatment for acne as good as antibiotics
8. Novel antibiotic shows promise in shortening treatment duration of tuberculosis
9. African children with HIV would benefit from daily doses of cheap antibiotic
10. Some antibiotic resistance threat in hospitals could yield to hand washing
11. Patients with chronic sinus do not necessarily develop antibiotic resistance

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/13/2017)... ATLANTA , Sept. 13, 2017   OrthoAtlanta ... to the Atlanta Football Host Committee (AFHC) for the 2018 ... Monday, Jan. 8, 2018, at Mercedes-Benz Stadium in ... part of the AFHC "I,m In" campaign, participating in many ... ...
Breaking Medicine Technology:
Cached News: