HOME >> MEDICINE >> NEWS
Three months is too soon to judge a CML patient's response to Gleevec, researchers find

hromosome is a molecular abnormality unique to CML cells. The fewer blood cells that test positive for it, the better the cytogenetic response.

For this study, researchers defined disease progression as blood counts no longer being controlled by Gleevec, loss of a cytogenetic response, advancement to accelerated phase or blast crisis, or death during treatment.

Researchers found that achieving a complete cytogenetic response, which refers to the Philadelphia chromosome disappearing altogether from a patient's blood cells, had a significant impact on a patient's long-term outcome regardless of when it occurred in treatment. Patients whose cytogenetic response was complete were least likely to experience disease progression.

Interestingly, the length of treatment needed to reach a complete response had no effect on survival. Survival without disease progression at 24 months was 96 percent for patients with a complete response within the first three to six months, and 93 percent for those who achieved a complete response only after six months.

Researchers also looked at which patients were likely to have a complete response to Gleevec. Patients who were 35 percent Philadelphia chromosome positive or less at any time during treatment often had a complete response. Patients who were greater than 95 percent Philadelphia chromosome positive at three months still had nearly a 50 percent chance of subsequently obtaining a complete response. However, patients who were greater than 95 percent Philadelphia chromosome positive after six months or more of therapy had no more than a 14 percent chance of achieving a complete response.

Thus, three months is too soon to judge a response to Gleevec. On the other hand, patients who are greater than 95 percent Philadelphia chromosome positive at six months may be candidates for other treatment options.

Researchers are further analyzing the data to find out if incre
'"/>

Contact: Rachel MacKnight
macknigh@ohsu.edu
503-494-8231
Oregon Health & Science University
6-Dec-2003


Page: 1 2 3

Related medicine news :

1. Three-year cervical cancer screening recommendations may be applicable for certain women with HIV
2. Three anti-platelet drugs used in combination are safe
3. Three out of the four million newborn babies who die each year could be saved
4. Three-year health study of teenage girls is underway at Trenton Central High School
5. Three Harvard Medical School endowed chairs named simultaneously in sleep medicine
6. Three Abbott chemists honored as Heroes for development of HIV therapy for children
7. Three Pfizer Inc chemists win Heroes award for epilepsy treatment for children, adults
8. Three Merck chemists win Heroes of Chemistry award for major asthma treatment advance
9. Three-time Emmy Award winning actress Kathy Baker to participate in ADHD experts on call program
10. Three-month antibiotic treatment reduces risk of future heart attack
11. Irritable Bowel Syndrome The Focus Of Three UNC-CH Reports At Digestive Diseases Conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/11/2019)... ... , ... Autopsies don’t lie. They report the causes of death as ... harms the heart. It increases risks of heart attack and death. Autopsies ... damage occurs. , An August 1, 2019 article in U.S. News ...
(Date:9/11/2019)... , ... September 10, 2019 , ... ... the team. Dr. Hesano is an understanding, caring and highly skilled Obstetrician/Gynecologist. ... obstetrical medicine. Dr. Hesano strives to ensure that each visit is comfortable, patient-focused, ...
(Date:9/9/2019)... ... September 09, 2019 , ... ST Engineering ... International will integrate the iDirect iQ 200 Board and the latest Evolution® software ... for first responders. The iQ 200 Board will enable the HARRIER solution to ...
(Date:9/9/2019)... ... September 09, 2019 , ... On ... organization-wide policy focusing on a diabetes-language movement (#LanguageMatters) to include oral and written ... non-judgmental, free from stigma, respectful and inclusive, empowering, and person-centered (to include care ...
(Date:9/8/2019)... ... 2019 , ... The reviews from patients of ABM Medical Clinic who have ... and pain free fat loss system, has patients booking their sessions and recommending this ... uses state of the art technology incorporating radio frequency and heat to rid the ...
Breaking Medicine News(10 mins):
(Date:9/11/2019)... ... September 11, 2019 , ... HOLLOWAY AMERICA, a leading manufacturer ... beverage to pharma and chemical, recently announced it will showcase its problem-solving vessels and ... , HOLLOWAY AMERICA’s first stop will be at ISPE San Diego’s 27th Life ...
(Date:9/11/2019)... ... 2019 , ... Pivot Point Consulting is excited to announce ... Partnerships team. Maris brings two decades of experience with Cerner—leading both sales ... as a Technical Implementation Leader representing the Technical Engagement Leader community. , Pivot ...
(Date:9/9/2019)... , ... September 09, 2019 , ... ... Shoreline Periodontics & Dental Implants host the latest course in their Synergy Study ... Mystic, CT and features guest speaker Dr. Peter Barndt. Synergy Study Club brings ...
Breaking Medicine Technology:
Cached News: