HOME >> MEDICINE >> NEWS
Three months is too soon to judge a CML patient's response to Gleevec, researchers find

hromosome is a molecular abnormality unique to CML cells. The fewer blood cells that test positive for it, the better the cytogenetic response.

For this study, researchers defined disease progression as blood counts no longer being controlled by Gleevec, loss of a cytogenetic response, advancement to accelerated phase or blast crisis, or death during treatment.

Researchers found that achieving a complete cytogenetic response, which refers to the Philadelphia chromosome disappearing altogether from a patient's blood cells, had a significant impact on a patient's long-term outcome regardless of when it occurred in treatment. Patients whose cytogenetic response was complete were least likely to experience disease progression.

Interestingly, the length of treatment needed to reach a complete response had no effect on survival. Survival without disease progression at 24 months was 96 percent for patients with a complete response within the first three to six months, and 93 percent for those who achieved a complete response only after six months.

Researchers also looked at which patients were likely to have a complete response to Gleevec. Patients who were 35 percent Philadelphia chromosome positive or less at any time during treatment often had a complete response. Patients who were greater than 95 percent Philadelphia chromosome positive at three months still had nearly a 50 percent chance of subsequently obtaining a complete response. However, patients who were greater than 95 percent Philadelphia chromosome positive after six months or more of therapy had no more than a 14 percent chance of achieving a complete response.

Thus, three months is too soon to judge a response to Gleevec. On the other hand, patients who are greater than 95 percent Philadelphia chromosome positive at six months may be candidates for other treatment options.

Researchers are further analyzing the data to find out if incre
'"/>

Contact: Rachel MacKnight
macknigh@ohsu.edu
503-494-8231
Oregon Health & Science University
6-Dec-2003


Page: 1 2 3

Related medicine news :

1. Three-year cervical cancer screening recommendations may be applicable for certain women with HIV
2. Three anti-platelet drugs used in combination are safe
3. Three out of the four million newborn babies who die each year could be saved
4. Three-year health study of teenage girls is underway at Trenton Central High School
5. Three Harvard Medical School endowed chairs named simultaneously in sleep medicine
6. Three Abbott chemists honored as Heroes for development of HIV therapy for children
7. Three Pfizer Inc chemists win Heroes award for epilepsy treatment for children, adults
8. Three Merck chemists win Heroes of Chemistry award for major asthma treatment advance
9. Three-time Emmy Award winning actress Kathy Baker to participate in ADHD experts on call program
10. Three-month antibiotic treatment reduces risk of future heart attack
11. Irritable Bowel Syndrome The Focus Of Three UNC-CH Reports At Digestive Diseases Conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... , ... July 10, 2020 , ... ... 3.0 featuring our Business Partner Vetting (BPV) Portal . Expresso® 3.0 ... upload requested documents. No more manually mailing, tracking, and performing other administrative tasks ...
(Date:7/7/2020)... ... July 07, 2020 , ... The ... head design to efficiently sanitize large surfaces is now available in Mexico and ... support sales in that region. , In this era of worldwide pandemic, the ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... treatment of autoimmune diseases. Its lead indication is vitiligo. Vitiligo patients develop ... time. , While vitiligo is equally prevalent in all ethnic groups, ...
(Date:7/2/2020)... SHELTON, Conn. (PRWEB) , ... July 02, 2020 ... ... closure of many businesses, including dental offices for non-emergency work. In conjunction with ... released reopening guidelines for Connecticut dental practices in mid-May. , Due to ...
(Date:7/1/2020)... ... 01, 2020 , ... The Society to Improve Diagnosis in ... the University of Massachusetts Medical School- Baystate and Ann Gaffey, RN, MSN, CPHRM, ... of Directors. Dr. Salvador and Ms. Gaffey’s service began in May and the ...
Breaking Medicine News(10 mins):
(Date:7/1/2020)... , ... July 01, 2020 , ... ... therapy (PDT) for treating cancer, today announced the formation of its Scientific Advisory ... will provide critical medical, scientific, and strategic advice to support company development and ...
(Date:6/28/2020)... ... June 28, 2020 , ... Probiotics have long ... the effectiveness of oral-care probiotics to maximize teeth and gum health. What ... both is simple – utilizing naturally occurring positive bacteria to improve health - ...
(Date:6/28/2020)... ... , ... CPAP Store USA, known for its one of a kind concept ... and expanding at a rapid rate. Today, CPAP store USA is excited to announce ... located at 3920 Rosemeade Parkway, Suite 150, Dallas, Texas 75287. , Opening the new ...
Breaking Medicine Technology:
Cached News: