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Three months is too soon to judge a CML patient's response to Gleevec, researchers find

asing the dose of Gleevec improves the likelihood of a major or complete response to the drug.

Druker will present the study (Abstract 634, Probability and Impact of Obtaining a Cytogenetic Response to Imatinib as Initial Therapy for Chronic Myeloid Leukemia in Chronic Phase) on Monday, Dec. 8, at 3:30 p.m. PST at the ASH 45th Annual Meeting in San Diego.

Gleevec also is an approved, effective treatment for gastrointestinal stromal tumors, a form of intestinal cancer that previously was often fatal. Earlier this year an editorial published in the New England Journal of Medicine dubbed Gleevec the "gold standard" treatment for CML, and the drug became the frontline therapy. Gleevec also earned the FDA's approval for use in children, the first new pediatric cancer drug treatment in more than a decade. Recent studies also have found Gleevec to be effective in treating hypereosinophilic syndrome, a rare and often fatal blood disorder.


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Contact: Rachel MacKnight
macknigh@ohsu.edu
503-494-8231
Oregon Health & Science University
6-Dec-2003


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