HOME >> MEDICINE >> NEWS
Timing appears essential to combining antiangiogenesis and radiation therapy

Although the earliest clinical trials of the cancer-fighting potential of antiangiogenesis drugs did not have the dramatic results that some hoped for, subsequent trials showed that combining agents that suppress blood-vessel growth with therapies that destroy cancer cells can improve patient survival. In the December issue of Cancer Cell, researchers from the Massachusetts General Hospital (MGH) describe how timing may be crucial to successfully combining angiogenesis inhibitors with radiation treatment and reveal more about exactly how these drugs work to fight cancer, which is somewhat different from earlier theories.

"The blood vessels that develop to supply nutrients to a tumor are not normal," says Rakesh Jain, PhD, director of the Steele Laboratory in the MGH Department of Radiation Therapy, the study's senior author. "The vessels are leaky, dilated, disfigured, and do not evenly inflitrate the tumor, which can interfere with standard cancer therapies. Chemotherapy drugs are not distributed throughout the tumor, and the oxygen level is low, making tumors resistant to radiation therapy. It now appears that antiangiogenic therapy transiently improves a tumor's blood supply and oxygenation, making it more vulnerable to radiation therapy."

Although some animal studies have suggested that combining antiangiogenesis and radiation therapy can slow tumor growth, in others the treatment appeared to spur tumor growth. The current investigation was designed to resolve these conflicting results and to improve understanding of the cellular and molecular underpinnings of antiangiogenesis treatment. The MGH researchers implanted human brain tumor tissue into mice that were then treated with various combinations of an angiogenesis inhibitor called DC101 and radiation therapy.

DC101 alone produced a minor delay in tumor growth, and radiation alone produced a more significant growth delay. But of five different schedules of combined treatment, o
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
20-Dec-2004


Page: 1 2 3

Related medicine news :

1. Timing of adverse events in hospital patients
2. Timing Of Breast Cancer Surgery Doesnt Appear To Influence Survival Anymore
3. Use of cell phone images appears feasible for visualizing leg wounds
4. Over-the-counter supplement appears effective in treatment of midlife-onset depression
5. Bone density appears to recover after adolescents discontinue injected contraceptive
6. Obesity appears to be modifiable risk factor for atrial fibrillation
7. Angioplasty, robotically assisted keyhole bypass combo appears effective
8. MRI appears to have advantages over CT scan for detecting bleeding in the brain in stroke patients
9. Pigment cell transplantation appears helpful for treating patients with stable vitiligo
10. Surgical treatment for obesity appears effective for weight loss and related disorders
11. Immune therapy appears to reduce risk of second attack of multiple sclerosis symptoms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/14/2019)... ... 2019 , ... Impact Advisors, a leading provider of clinical, ... John Stanley, Vice President, has been named one of the “Top 25 Consultants” ... has been recognized in the Excellence in Healthcare category. He will attend the ...
(Date:5/14/2019)... (PRWEB) , ... May 14, 2019 , ... A high ... one of the top health crises in the Houston area and the southern United ... Hispanic men who have sex with men (MSM) and transgender people ...
(Date:5/14/2019)... NASHVILLE, Tenn. (PRWEB) , ... May 14, 2019 ... ... announced today the availability of the Relatient® eRegistration and Check-In solution , ... prior to an appointment. The solution builds on Relatient’s Patient Engagement ...
(Date:5/14/2019)... ISLIP, N.Y. (PRWEB) , ... May 14, 2019 ... ... That’s the price tag put on anti-aging products and procedures, according to market ... registered Physician Assistant specializing in Dermatology with Advanced Dermatology PC , “but ...
(Date:5/14/2019)... ... ... Dr. Steven Shoshany has been treating patients experiencing both acute and long ... therapy device, becoming the first chiropractor in Manhattan to do so. Since January, Dr. ... for treating pain and injuries, into his downtown practice. He recently finished designing a ...
Breaking Medicine News(10 mins):
(Date:5/16/2019)... , ... May 16, 2019 , ... Join John Cogan, ... David Berglund, Global Head Regulatory Operations at AstraZeneca in a live webinar ... technologies can modernize Regulatory Information Management (RIM) systems. , As Regulatory Operating models ...
(Date:5/15/2019)... ... May 15, 2019 , ... Claudius Moore, a seasoned technology ... of Information Technology. Over the last 15 years, Moore has mastered a method ... also creating a high-quality, efficient experience for patients. , Moore will lead AFC’s ...
(Date:5/15/2019)... , ... May 15, 2019 , ... ... Customer Success Report to give prospects better insight on which Emergency Mass ... , The highest rated vendors according to the 2019 Spring Emergency Mass Notification ...
Breaking Medicine Technology:
Cached News: