HOME >> MEDICINE >> NEWS
Tobacco chemical protects against Parkinson's disease

SAN FRANCISCO, March 27 -- For the first time, scientists have identified a chemical in tobacco that may explain why smokers are statistically less vulnerable to Parkinson's disease. The compound has been shown to slow the breakdown of key brain chemicals, including dopamine, which is typically depleted in the brains of patients with Parkinson's disease, according to researchers at Virginia Tech. The association between smoking and Parkinson's disease has been known for more than 20 years, but until now could not be scientifically explained.

The findings were presented here today at the 219th national meeting of the American Chemical Society, the world's largest scientific society, by Kay Castagnoli, a senior research associate in the Department of Chemistry and a member of the school's Harvey W. Peters Center for the Study of Parkinson's Disease.

The tobacco compound is described as a derivative of naphthoquinone, and works by interfering with an enzyme in the brain known as monoamine oxidase (MAO). MAO typically breaks down neurotransmitters - including dopamine, serotonin, and norepinephrine - as part of normal chemical activity in the brain.

In their study, the Virginia Tech researchers administered MPTP, a designer drug that produces a Parkinson-like disease, to laboratory rodents. Sold in the early l980s, MPTP was meant to mimic the effects of heroin. Addicts who took large doses suffered severe Parkinsonian symptoms. The naphthoquinone derivative protected the rodents against the toxic effects of MPTP, according to the researchers.

The researchers have started a second rodent study to confirm their initial findings. In addition, tests are underway in which the blood platelets of smokers are examined - before and after they smoke - to see if the naphthoquinone or related tobacco-derived compounds reduce MAO activity. The results will be correlated with the effects of the napththoquinone on MAO activ
'"/>

Contact: Charmayne Marsch
y_marsh@acs.org
202-872-4445
American Chemical Society
26-Mar-2000


Page: 1 2

Related medicine news :

1. Mailman School of Public Health receives Manhattan Tobacco Cessation Center grant
2. Tobacco industry pays scientists to challenge secondhand smokes link to infant death risk
3. Exposed: Tobacco industrys efforts to cast doubt
4. Tobacco-company-sponsored parties with free cigarettes may encourage students to start smoking
5. Hopkins Institute for Global Tobacco Control receives elite recognition from PAHO/WHO
6. Tobacco sponsorship of Formula One must stop, say health experts
7. UCI Tobacco research center reports why teens are most vulnerable to smoking addiction
8. Tobacco should be excluded from free trade agreement
9. Tobacco use common in schools demonstrating poor academic performance
10. Tobacco industry strategies for influencing European community tobacco advertising legislation
11. Federal institutes and the Robert Wood Johnson Foundation create Tobacco Use Research Centers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/11/2018)... ... November 09, 2018 , ... ... has joined the #GivingTuesday movement. Kicking off the giving season, #GivingTuesday is an ... the widely recognized shopping events Black Friday and Cyber Monday. , ACMA’s ...
(Date:11/11/2018)... ... 11, 2018 , ... Cortney Afton, registered dietitian and nutrition care coordinator for ... a positive impact on the lives of her consumers. “Every day when I leave ... many wonderful resources in Kalamazoo and this Mobile Kitchen initiative is one of them.” ...
(Date:11/9/2018)... ... November 09, 2018 , ... Bio-Logic Aqua® Research ... for dry eye that restores lipids and proteins to the aqueous layer of ... on Youtube from founder Sharon Kleyne and Bio-Logic Aqua® Research Water Life Science® ...
(Date:11/9/2018)... ... November 08, 2018 , ... Achla Karnani is ... , Caring Transitions’ specially-trained team can handle organizing, packing, de-cluttering, moving, resettling, in-person ... in assisting seniors, but their services are great for any families or individuals ...
(Date:11/8/2018)... ... November 08, 2018 , ... How ... different media sources could impact how they view advertising and earned media in ... Connections, Inc. will release results of the tenth annual study of the media ...
Breaking Medicine News(10 mins):
(Date:11/13/2018)... ... November 13, 2018 , ... ... pioneer in cloud computing , today announced that LifeNet Health , ... process. Esker’s cloud-based AP solution is integrated with the company’s SAP® ...
(Date:11/13/2018)... , ... November 13, 2018 , ... ... microbial genomics, has awarded microbiome research support in study design, planning, sample collection, ... by Dr. Marc Braunstein, PhD, MD, Assistant Professor of Clinical Medicine, to compare ...
(Date:11/13/2018)... ... 13, 2018 , ... New Cleveland Clinic Study Shows Bariatric ... undergone weight-loss or bariatric surgery, and later suffer unrelated heart failure, cut their ... according to a new study from Cleveland Clinic researchers who presented their ...
Breaking Medicine Technology:
Cached News: