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Top-ups of naturally occurring gut hormone could help treat obesity

the Hammersmith Hospital Sir John McMichael Research Centre at 8.30 am. They were then given a ninety minute infusion (placed on an intravenous drip) of either PYY3-36 or placebo (a saline solution). Two hours after the end of the infusion, where the volunteers did not know if they were receiving the PYY3-36 or the placebo, they were offered an unlimited buffet meal.

All 24 volunteers ate less on the day when they received a PYY3-36 infusion compared with the placebo day. Overall PYY3-36 reduced calorific intake by a third in both the lean and obese subjects.


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Contact: Tony Stephenson
at.stephenson@imperial.ac.uk
44-0-20-7594-6712
Imperial College London
3-Sep-2003


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