HOME >> MEDICINE >> NEWS
Transplanted human neural stem cells improve memory in rats

Laboratory-grown human neural stem cells, the building blocks of the brain, were successfully transplanted for the first time into the brains of aged rats and dramatically improved the animals' cognitive function, according to a study by University of Illinois at Chicago researchers.

Researchers led by Kiminobu Sugaya, an assistant professor of psychiatry at UIC, found that in a spatial memory task, aged rats that had received the transplants were able to perform as well as younger rats without memory impairments. The findings are reported in the May 1 edition of NeuroReport, a fully refereed online journal that offers fast publication times for breaking scientific news. The journal is devoting a special issue to this paper.

The research is a first step in Sugaya's hope of curing neurodegenerative diseases in humans by replacing overworked brain cells with fresh cultured stem cells. The transplantation of stem cells, followed by incorporation of the cells into the host brain and subsequent cognitive improvement, is the first successful experiment of its kind in the world. The results of the study could lay the foundation for new treatments in diseases such as Alzheimer's and Parkinson's.

Neural cell transplant studies recently suffered a setback when transplanted fetal cells worsened symptoms in Parkinson's patients. However, Sugaya pointed out, his team injected different types of cells into the brain-not already differentiated neural fetal cells but laboratory-grown stem cells, which are not differentiated.

This tactic allowed the host brain to take over, dictating where the stem cells should migrate and what types of cells they should become. As a result, Sugaya said, the transplanted cells became functionally integrated into the neuronal circuitry of the host animal.

"We believe this offers a promising line of research in treating brain disorders," said Sugaya.

In the study, 32 rats were trained to swim to a hidden escape platform i
'"/>

Contact: Sharon Butler
sbutler@uic.edu
312-355-2522
University of Illinois at Chicago
30-Apr-2001


Page: 1 2

Related medicine news :

1. Transplanted bone marrow cells reduce liver fibrosis in mice
2. Transplanted kidneys from living donors survive longer with Neoral compared with tacrolimus
3. New Strategy May Succeed At Extending The Life Of Transplanted Kidneys
4. Therapy Developed At Cedars-Sinai Medical Center Shows Promise In Preventing Rejection Of Transplanted Organs
5. Bone Marrow With Heart And Lung Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
6. Bone Marrow With Organ Transplants Reduces Rejection Of Transplanted Organs, Reports University Of Pittsburgh
7. UIC professor receives international humanitarian award
8. UCSF study offers insight into human circadian rhythms
9. Hopkins begins human trials with donor adult stem cells to repair muscle damaged from heart attack
10. Protecting human subjects focus of national FDA conference at UH
11. Test could improve detection of prion disease in humans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder ... of ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership ... rules. It also provides a forum to network with elder law attorneys nationwide,” said ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... 13, 2017   OrthoAtlanta has been named the ... Host Committee (AFHC) for the 2018 College Football Playoff (CFP) ... at Mercedes-Benz Stadium in Atlanta, Georgia . ... "I,m In" campaign, participating in many activities leading up to, ... ...
(Date:9/12/2017)... reviews on the independent review site Consumer Affairs have ... hearing aids, ranking it higher than Miracle Ear ™, Beltone™, ... ... Aids ... that provides high performance, state-of-the-art, German-engineered hearing aids directly to consumers ...
(Date:9/9/2017)... ... ... – Monday, September 18 th .The Brain Tumor Foundation (BTF) begins ... the public.Where:  BTF,s Mobile MRI Unit – a ... Washington, D.C.What:BTF brings its nationwide initiative, the Road to Early Detection Sponsor-A-City ...
Breaking Medicine Technology:
Cached News: