HOME >> MEDICINE >> NEWS
Transport system smuggles medicines into brain

Dutch researcher Corine Visser investigated a new way of transporting medicines into the brain. Her approach made use of an iron transport system located on the blood-brain barrier. The smaller the medicine, the more easily it penetrates the brain.

A special barrier between the blood and the brain, the so-called blood-brain barrier (BBB), protects the brain from toxic substances. It only lets through important nutrients for the brain such as iron, glucose and oxygen. Visser allowed larger molecules, such as medicines, to pass through the blood-brain barrier by attaching these to the iron-containing protein transferrin. This technique allowed the medicines to 'hitch a lift' and pass unnoticed though the BBB. How much medicine reaches the brain depends on the size of the molecule attached to the transferrin.

Much of the BBB is made up of capillary endothelial cells, the cells which line the walls of blood vessels. In the brain, unlike other parts of the body, these cells are closely packed together. This makes it almost impossible for substances to pass between the cells. Further in the brain, few substances can pass through the endothelial cells.

Transferrin is a protein in the blood that contains two iron atoms. On reaching the BBB it binds to transferrin receptors on the endothelial cells. Once the transferrin has bound to the receptor, a vesicle in the cell completely engulfs it. The transferrin then releases the iron atoms, which are brought to the brain by another protein. A major advantage of this transport system with vesicles is that larger molecules can pass through the BBB. The vesicle has a diameter of about 120 nanometres.

Conjugation

In three stages, Visser investigated how medicines can enter the brain via the transferrin receptor. In the first stage she demonstrated the presence of the receptor in her BBB model by using radioactively-labelled transferrin. She then conjugated an enzyme to the transferrin. With
'"/>

Contact: Dr Corine Visser
ccvisser@freeler.nl
31-71-527-6269
Netherlands Organization for Scientific Research
11-Feb-2005


Page: 1 2

Related medicine news :

1. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
2. Strengths and failings of U.S. health care system are driven by embedded vested interests
3. Physicists find patterns within seemingly random events of physiological systems
4. Chemists identify immune system mechanism for methamphetamine binges
5. Most hospital executives have substantial concerns about mandatory error reporting systems
6. New hand-held information system for emergency responders
7. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
8. New NHS payment system is no panacea
9. Computerized order entry systems can increase risk of medication errors
10. New system for the analysis of facial movement in three dimensions
11. Study: Two brain systems regulate how we call for help

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2020)... ... January 23, 2020 , ... ... memory impairment, has announced the Best Memory Care Facilities in Pensacola, Florida. The ... features and amenities. , According to the Alzheimer’s Association , 5.6 ...
(Date:1/23/2020)... , ... January 23, 2020 , ... ... brief demonstrating that in 2019, the Trump Administration dramatically expanded upon discriminatory, ... well-being of LGBTQIA+ people in America and around the world. , “During Donald ...
(Date:1/23/2020)... , ... January 23, 2020 , ... ... filled and delivered, officially launched in Orange County today with the grand opening ... prescriptions in a fraction of the time of a traditional pharmacy. NowRx ...
(Date:1/22/2020)... ... January 22, 2020 , ... “In preparation for our ... foundational systems,” said Bill Schnittker, LIDP Founder and CEO. “We introduced Titanium, a ground-breaking, ... new claims processing systems suite. In 2019 LIDP launched CSR and Agent Portals.” ...
(Date:1/10/2020)... ... January 10, 2020 , ... Ziegler, a specialty ... to Radiology Ltd. on its partnership with US Radiology Specialists (“USRS”), backed by ... Radiology Ltd. is the largest private practice radiology group and outpatient imaging operator ...
Breaking Medicine News(10 mins):
(Date:1/22/2020)... ... January 22, 2020 , ... Biodex Medical ... to U.S. customers. A total redesign of their legacy software, the modern interface ... and intuitive navigation, while maintaining the testing and training accuracy they expect from ...
(Date:1/22/2020)... ... 2020 , ... Somatus, the market leader in providing value-based ... today announced it is expanding its renal management partnership with BlueCross BlueShield of ... kidney disease (CKD). This partnership previously only served BCBST’s Medicare Advantage members with ...
(Date:1/22/2020)... BRUNSWICK, N.J. (PRWEB) , ... January 22, 2020 , ... ... Patent (US 10,500,240) on Terminalia chebula. This newly granted patent expands Natreon’s strong patent ... trials. , The primary claim in this patent is, “a method of treating ...
Breaking Medicine Technology:
Cached News: