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Transport system smuggles medicines into brain

the enzyme attached, the transferrin also bound to the receptor and was taken up in the cells of the BBB.

Finally, Visser attached a tiny fat bubble (liposome) containing small molecules, such as medicines, to the transferrin. She discovered that the transferrin with the liposome attached was also taken up by the cell. However, the cell subsequently broke down the liposomal content, because the liposomes were significantly bigger than the previously linked enzyme. Liposomes have a diameter of 100 nanometres and the enzyme a diameter of 3 to 4 nanometres. Therefore a liposome or a direct conjugation can be chosen, dependent on the intracellular destination of the medicine.


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Contact: Dr Corine Visser
ccvisser@freeler.nl
31-71-527-6269
Netherlands Organization for Scientific Research
11-Feb-2005


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