HOME >> MEDICINE >> NEWS
Treating individuals: How generalisable are trial data?

A five-part series about clinical trial data and its applicability to individual patients begins in this week's issue of THE LANCET.

The first article discusses the issues that can limit the generalisability of data from randomised trials and systematic reviews into clinical practice. Subsequent articles will reflect common clinician concerns about subgroups, meta-analyses, and risk.

Peter Rothwell (University of Oxford, UK), co-ordinator of the series and author of the first article, comments: "RCTs and systematic reviews cannot be expected to produce results that are directly relevant to all patients and all settings, but to be externally valid they should at least be designed and reported in a way that allows patients and clinicians to judge to whom they can reasonably be applied. While cognisant of the risks of over-regulation, some of the following recommendations might be worthwhile:

  • Further research into the external validity of RCTs, particularly in relation to the measured treatment effect.

  • Stricter requirements than previously for the external validity of RCTs submitted to pharmaceutical licensing authorities.

  • Increased consideration of external validity in the CONSORT guidelines on the reporting of RCTs, and the Cochrane Collaboration guidelines on systematic reviews, and agreement on a checklist.

  • The International Committee of Medical Journal Editors should require that all primary reports of RCTs or systematic reviews should contain a section entitled "To whom do these results apply?"

    William Summerskill from The Lancet discusses the series in an accompanying commentary (p 13): "Let us not neglect the central role of patients as decision-makers in their own care. It is the responsibility of healthcare workers to communicate objective evidence in a manner which allows recipients to make an informed choice, and then to respect that choice. To empower consumers to make informed choice
    '"/>



  • Contact: Joe Santangelo
    j.santangelo@elsevier.com
    1-212-633-3810
    Lancet
    30-Dec-2004


    Page: 1 2

    Related medicine news :

    1. Treating depression helps slow physical decline in older adults, study shows
    2. Treating blood clots, a half-century later
    3. Treating older adults for flu is cost-effective, but preventing it with a yearly flu shot is better
    4. Treating depression important for reducing death after bypass surgery
    5. Treating acid reflux reduces asthma symptoms and improves quality of life in patients with asthma
    6. Treating effects of brain damage
    7. Treating eye pain may remove other migraine symptoms
    8. New study: Treating depression, low social supports does not reduce heart patients deaths, heart attacks
    9. Two Beta-Blocker Drugs Equal In Treating Heart Failure
    10. DDW Studies Present Evidence That Thalomid (Thalidomide) Is Active In Treating Crohns Disease
    11. Treating Depression Makes A Healthier Heart

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
    (Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
    (Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
    (Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
    (Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
    Breaking Medicine News(10 mins):
    (Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
    (Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
    (Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
    Breaking Medicine Technology:
    Cached News: