Treatment of insulin resistance may have the potential to reduce long-term complications of type 2 diabetes

Brussels, Belgium, 28 September 1999: New data presented at this week's European Association for the Study of Diabetes (EASD) meeting in Brussels show that the new oral treatment for type 2 diabetes, rosiglitazone, reduces insulin resistance, offering glycaemic control and additional beneficial effects on other important risk factors of the disease. Results suggest that rosiglitazone may have the potential to reduce late-stage complications.

"The new studies show that by directly targeting insulin resistance, one of the fundamental defects in type 2 diabetes, rosiglitazone treatment may improve a whole range of metabolic abnormalities," said Dr George Bakris of the Rush University Hypertension Center, Chicago, USA.

Insulin resistance is a fundamental defect in type 2 diabetes, and the risk of coronary heart disease is approximately doubled in individuals with insulin resistance, regardless of whether the person also has type 2 diabetes. (1) Other associated metabolic changes, such as high blood concentrations of insulin and excretion of a protein known as albumin in the urine, are also 'markers' for the risk of coronary heart disease. (2,3)

A series of new studies being presented at EASD show that rosiglitazone, by directly reducing insulin resistance, gives long-term control of blood glucose (4,5) as well as offering other benefits.

Reduced insulin resistance . Using an indirect method of analysis, without invasive tests, investigators report that rosiglitazone monotherapy (8 mg/day) reduced insulin resistance by 33% compared with placebo in just 26 weeks of treatment. Rosiglitazone was also added to existing treatment with another oral anti-diabetes drug (a sulphonylurea). When compared with sulphonylurea plus placebo, the addition of rosiglitazone (4 mg/day) reduced insulin resistance by 32% over 26 weeks. Over 1400 individuals with type 2 diabetes were included in these studies. Some were new to drug therapy and others had r

Contact: Susie Hackett/Alexa Osman
MediTech Media Ltd.

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