HOME >> MEDICINE >> NEWS
Trial reveals safer and simpler approach to treating children with cystic fibrosis

Treating chest infections in young cystic fibrosis patients with an antibiotic once instead of three times daily is as effective and less toxic, conclude the results of a randomised trial published in this week's issue of THE LANCET.

Aminoglycoside antibiotics are widely used for the management of patients who have cystic fibrosis and chronic chest infection with a bacterium called Pseudomonas aerginosa. Currently patients are given aminoglycosides three times daily. The drugs can cause damage to kidney function and hearing loss.

Alan Smyth (University of Nottingham, UK) and colleagues recruited 219 cystic fibrosis patients (125 children and 94 adults) between 1999 and 2003 in the UK. The patients were randomly assigned to receive an aminoglycoside called tobramycin intravenously once or three times daily for 14 days. The researchers measured changes in lung function and found that the two treatments had a similar effect. However in children, the once daily treatment caused fewer kidney related side effects.

Dr Alan Smyth comments: "Our results are likely to affect aminoglycoside prescription in cystic fibrosis in clinical practice. Once daily treatment may be preferred by patients receiving intravenous antibiotics because of its convenience. Antipseudomonal antibiotics are usually given as combinations of two or more drugs in cystic fibrosis because of concerns of emerging antibiotic resistance. Most other antipseudomonal antibiotics need to be given three times daily and so further development of other once daily antibiotics would be useful."

In an accompanying commentary Heather VandenBussche (Bronson Methodist Hospital, Michigan, USA) and Michael Klepser (Ferris State University College of Pharmacy, Michigan, USA) write that several unanswered questions persist about once daily aminoglycoside dosing in cystic fibrosis patients.

Dr VandenBussche concludes: " Smyth and colleagues' report provides some useful insights into
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
10-Feb-2005


Page: 1 2

Related medicine news :

1. Trials launched to test treatment of cognitive dysfunction in schizophrenia
2. Randomisation phase of the DIRECT programme (DIabetic REtinopathy Candesartan Trials) completed
3. Trials on hormone therapy and hypertension treatment change practice, medication usage of patients
4. Trial results have dramatically reduced HRT use
5. Release of results of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
6. Trial opens new possibilities for improving survival with a novel heart attack drug
7. Clinical Trials Litigation: Legal & Ethical Issues in Human Subjects Research
8. National Lung Screening Trial
9. New awards, expanded focus for Pediatric AIDS Clinical Trials Group
10. AAPS Workshop to Examine Chemistry and Manufacturing Controls Trials, Emerging Products
11. Abgenix Reports Positive Survival Data From A Phase II Trial Of ABX-CBL In Graft Versus Host Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/30/2020)... ALTO, Calif. (PRWEB) , ... May 30, 2020 ... ... them with advanced technology and virtual solutions that can meet the needs of ... world. , HashCash’s healthcare solutions abide by the necessary compliances and ...
(Date:5/28/2020)... ... 2020 , ... Today the National Kidney Registry (NKR) announced ... be reimbursed for lost wages and travel/lodging costs for any donation-related complications as ... lost wage reimbursement for donation, travel & lodging reimbursement for donation, donation life ...
(Date:5/27/2020)... ... May 27, 2020 , ... Productive Plastics, a leading ... face shields to be used as personal protective equipment (PPE) to combat ... single use, made to be worn by frontline healthcare professionals and for any ...
(Date:5/27/2020)... ... 27, 2020 , ... Radiology Associates of Richmond (RAR), one ... aligned with the Strategic Radiology (SR) coalition of independent practices. , RAR ... coalition, which has 28 member practices in 20 different states. The Richmond practice ...
(Date:5/26/2020)... ... May 26, 2020 , ... ... can impact the brain causing post infectious encephalitis. The work was conducted ... and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) could adversely attack the central nervous ...
Breaking Medicine News(10 mins):
(Date:6/3/2020)... ... 2020 , ... The Conference Forum announced the launch of the first virtual ... September 21st, 2020. This annual conference challenges biopharma R&D on how to embrace, adapt ... to participate in clinical research. , “This event comes at a critical time,” says ...
(Date:6/3/2020)... ... June 03, 2020 , ... ... today the addition of connected device capabilities to its mobile device and telehealth ... capabilities come at a time when an increasing number of home health agencies ...
(Date:6/2/2020)... TAMPA, Fla. (PRWEB) , ... June 02, 2020 ... ... non-clinical healthcare, Harmony Healthcare announced today that in response to COVID-19 it is ... job security, updated remote and on-site solutions, reimbursements, and a host of digital ...
Breaking Medicine Technology:
Cached News: