HOME >> MEDICINE >> NEWS
Trial reveals safer and simpler approach to treating children with cystic fibrosis

Treating chest infections in young cystic fibrosis patients with an antibiotic once instead of three times daily is as effective and less toxic, conclude the results of a randomised trial published in this week's issue of THE LANCET.

Aminoglycoside antibiotics are widely used for the management of patients who have cystic fibrosis and chronic chest infection with a bacterium called Pseudomonas aerginosa. Currently patients are given aminoglycosides three times daily. The drugs can cause damage to kidney function and hearing loss.

Alan Smyth (University of Nottingham, UK) and colleagues recruited 219 cystic fibrosis patients (125 children and 94 adults) between 1999 and 2003 in the UK. The patients were randomly assigned to receive an aminoglycoside called tobramycin intravenously once or three times daily for 14 days. The researchers measured changes in lung function and found that the two treatments had a similar effect. However in children, the once daily treatment caused fewer kidney related side effects.

Dr Alan Smyth comments: "Our results are likely to affect aminoglycoside prescription in cystic fibrosis in clinical practice. Once daily treatment may be preferred by patients receiving intravenous antibiotics because of its convenience. Antipseudomonal antibiotics are usually given as combinations of two or more drugs in cystic fibrosis because of concerns of emerging antibiotic resistance. Most other antipseudomonal antibiotics need to be given three times daily and so further development of other once daily antibiotics would be useful."

In an accompanying commentary Heather VandenBussche (Bronson Methodist Hospital, Michigan, USA) and Michael Klepser (Ferris State University College of Pharmacy, Michigan, USA) write that several unanswered questions persist about once daily aminoglycoside dosing in cystic fibrosis patients.

Dr VandenBussche concludes: " Smyth and colleagues' report provides some useful insights into
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
10-Feb-2005


Page: 1 2

Related medicine news :

1. Trials launched to test treatment of cognitive dysfunction in schizophrenia
2. Randomisation phase of the DIRECT programme (DIabetic REtinopathy Candesartan Trials) completed
3. Trials on hormone therapy and hypertension treatment change practice, medication usage of patients
4. Trial results have dramatically reduced HRT use
5. Release of results of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
6. Trial opens new possibilities for improving survival with a novel heart attack drug
7. Clinical Trials Litigation: Legal & Ethical Issues in Human Subjects Research
8. National Lung Screening Trial
9. New awards, expanded focus for Pediatric AIDS Clinical Trials Group
10. AAPS Workshop to Examine Chemistry and Manufacturing Controls Trials, Emerging Products
11. Abgenix Reports Positive Survival Data From A Phase II Trial Of ABX-CBL In Graft Versus Host Disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/8/2019)... ... ... Over the past three decades, Buffalo Wings & Rings has elevated the chicken wing ... higher-quality product and experience than the competition. Now, the club-level sports restaurant brand has ... THE CAUSE" campaign in support of Breast Cancer Awareness Month. , “We are ...
(Date:10/8/2019)... ... 08, 2019 , ... METAvivor Research and Support Inc., a non-profit organization dedicated ... Stage IV Stampede campaign. The campaign will commence with two days of action and ... advocacy boot camp, a march, a Die-In (hosted by partner MET-UP), and visits with ...
(Date:10/8/2019)... ... October 08, 2019 , ... ... CardioWise, Inc. a Digital Health Awards 1st Round (Top Ten) Finalist in ... Awards was to select companies that promote faster, better, more cost-effective healthcare by ...
(Date:10/8/2019)... ... October 08, 2019 , ... Dr. Marc Lazare, a ... an advanced Level III training in Cagliari, Italy, this past September to further ... September 16-19, 2019 at the Sardinia Dental Teaching Center and covered several advanced ...
(Date:10/8/2019)... ... October 08, 2019 , ... Fewer than 50 percent of ... reproducible. Rigor in bioanalytical method validation is emerging in the form of a ... of the time) and senior scientists add the management of an offshore team ...
Breaking Medicine News(10 mins):
(Date:10/10/2019)... LOS ANGELES (PRWEB) , ... October 10, 2019 , ... ... and Modern Living with kathy ireland® is pleased to announce their recent ... Gamble's Herbal Essences showcasing how they help consumers of all abilities identify and choose ...
(Date:10/8/2019)... ... October 08, 2019 , ... Help.org, a trusted online ... Best Rehab Facilities in Boston, Massachusetts for 2019. The informational guide recognizes the top ... , According to recent studies , drug overdose is the leading cause of ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... ... participated in an advanced dental implant seminar to enhance his skill and knowledge ... country, The Implant Dentistry Continuum™ is a four-part series of classes that combines ...
Breaking Medicine Technology:
Cached News: