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The investigators concluded that their findings suggest that treatment of C-subtype HIV-1 infections with regimens that have been used against B-subtype infections "will have significant virological and immunological benefit, even in the setting of opportunistic infection and low CD4 counts."

In an accompanying editorial, Timothy P. Flanigan and coworkers in Providence, Rhode Island, Denver, Colorado, and Chennai, India, commented that the findings of this study, along with those of other recent studies, have shattered two myths about treating HIV infection in the developing world: that the benefits obtained in developed countries cannot be replicated in poor settings, and that patients in developing countries are too ill with opportunistic diseases to benefit from antiretroviral therapy. They pointed out, however, that the long-term effects of treatment will need to be demonstrated in further studies by Cassol and coworkers and other investigators.

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Contact: Steve Baragona
sbaragona@idsociety.org
703-299-0412
Infectious Diseases Society of America
28-Dec-2004