Tuberculosis strains stay close to home, say Stanford researchers

STANFORD, Calif. - Taking advantage of the open-air laboratory that is San Francisco, Peter Small, MD, has collected samples of virtually every case of tuberculosis that has occurred in the city for the last 13 years - almost 3,000 total. In this week's advance online edition of The Proceedings of the National Academy of Sciences, the associate professor of infectious diseases and geographic medicine at the Stanford University School of Medicine and his colleagues present a genetic analysis of 100 of these samples. The findings suggest ways the bacteria can escape a host's immune system or develop antibiotic resistance.

The team took its analysis a step further in a second paper, which appears in the same edition of the journal. They found that people from different regions of the world carry different strains of the tuberculosis bacteria, pointing out the importance of sociological interactions in infectious disease transmission. This also raises the possibility that the pathogen evolves within a geographic population group and doesn't spread to other groups.

"It was remarkable how well the genetics mapped to global geography," said Small. "Co-evolution is highly speculative, but it's an intriguing possibility. Most importantly, it's a hypotheses we now have the technology to address."

Tuberculosis causes more adult deaths than any other infectious disease. Worldwide, one person in three is infected, but it remains a problem primarily in the developing world. However, the emergence of tuberculosis strains resistant to multiple drugs in industrialized countries is prompting renewed interest in vaccination.

There has long been anecdotal evidence that tuberculosis bacteria differ throughout the world, said Small, who is currently on leave from Stanford serving as a senior program officer in the Global Health Program of the Bill and Melinda Gates Foundation. Additionally, he said, studies testing tuberculosis vaccines have varied widely

Contact: Mitzi Baker
Stanford University Medical Center

Page: 1 2 3

Related medicine news :

1. Tuberculosis drug combined with virtual reality therapy is effective in treating fear of heights
2. UCSD Medical Center receives NIH contract to set up National Tuberculosis Educational Curriculum
3. Tuberculosis Foundation selects Core Research Scientists
4. New quick test for drug-resistant strains of gonorrhea
5. Nabi StaphVAX elicits antibodies with in vitro activity against antibiotic-resistant Staphylococcus aureus strains
6. War on bacteria could leave drug-resistant strains unchecked
7. New data provide further evidence of effectiveness of targeted delivery of Relenza and efficacy in both A&B strains
8. Indiana University researchers closer to helping hearing-impaired using stem cells
9. Chemicals in tattoo inks need closer scrutiny
10. Researchers close in on breast cancer vaccine
11. Drug companies should disclose adverse events before licensing

Post Your Comments:

(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Leading pediatric ... peers in Washington, D.C., for the 49th Congress of the International Society of ... Vice President of the Center for Cancer and Blood Disorders at Children’s ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... in Las Piedras, Puerto Rico , ... Following a ... sustained minor structural damage, temporary loss of power and ... been completed, manufacturing operations have resumed, and the company ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
Breaking Medicine Technology:
Cached News: